Exploring molecular mechanism of Panlongqi Tablet (PLQT) against RA: Integrated network pharmacology, molecular docking and experiment validation DOI
Huixin Song, Jinjin Yu,

Yajie Yang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113639 - 113639

Published: Nov. 30, 2024

Language: Английский

The emerging role of vascular endothelial cell-mediated angiogenesis in the imbalance of RA synovial microenvironment and its clinical relevance DOI Creative Commons
Xingxing Huo,

Yanhui Peng,

Hui Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 4, 2025

Vascular endothelial cells (VEC) play a key role in the occurrence and progression of vascular inflammation. VEC activation secretes powerful inflammatory mediators aggravates development rheumatoid arthritis (RA). Angiogenesis plays pathological processes inflammation synovial infiltration, driving RA progression. A substantial amount evidence suggests that at site is both an active participant regulator process. At present, research progress still incomplete. In this review, we summarize angiogenesis RA, describe relevant cells, cytokines signaling pathways involved regulation, provide clues on post-translational modification (PTMs) function classify integrate these mechanisms therapeutic strategies. This review aims to synthesize current support established link between RA-related pathology, theoretical basis for clinical studies, valuable insights into drugs against RA.

Language: Английский

Citations

0
Sinomenine ameliorates vascular calcification by inhibiting pyroptosis-related molecules and AEG-1 in chronic kidney disease DOI
Zengqi Tang,

Fengyi Yu,

Zhong Peng

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177594 - 177594

Published: April 1, 2025

Language: Английский

Citations

0
The Yin and Yang of the Natural Product Triptolide and Its Interactions with XPB, an Essential Protein for Gene Expression and DNA Repair DOI Open Access
David Gorrie,

Marco Bravo,

Li Fan

et al.

Genes, Journal Year: 2024, Volume and Issue: 15(10), P. 1287 - 1287

Published: Sept. 30, 2024

Triptolide, a bioactive diterpene tri-epoxide extracted from

Citations

1
Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis DOI Open Access

Kuanhui Gao,

Lizhi Lv, Zhichao Li

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Degenerative bone and joint diseases (DBJDs), characterized by osteoporosis, osteoarthritis, chronic inflammation of surrounding soft tissues, are systemic conditions primarily affecting the skeletal system. Ferroptosis, a programmed cell death pathway distinct from apoptosis, autophagy, necroptosis. Accumulating evidence suggests that ferroptosis is intricately linked to pathogenesis DBJDs, targeting its regulation could be beneficial in managing these conditions. Natural products, known for their anti-inflammatory antioxidant properties, have shown unique advantages preventing potentially through modulating ferroptosis. This article provides an overview latest research on ferroptosis, with focus role DBJDs therapeutic potential natural products this pathway, offering novel insights prevention treatment DBJDs.

Language: Английский

Citations

0
Exploring molecular mechanism of Panlongqi Tablet (PLQT) against RA: Integrated network pharmacology, molecular docking and experiment validation DOI
Huixin Song, Jinjin Yu,

Yajie Yang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113639 - 113639

Published: Nov. 30, 2024

Language: Английский

Citations

0