SDCBP Orchestrated Gastric Cancer Aggression Through Epithelial‐ Mesenchymal Transition and Macrophages M2 Polarization

Molecular Carcinogenesis, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

ABSTRACT Gastric cancer remains a significant global health burden with limited treatment options and high mortality. Syndecan‐binding protein (SDCBP), scaffolding involved in tumor differentiation, has attracted attention as potential therapeutic target cancers. However, its precise role gastric progression is not fully understood. In this study, through bioinformatics analysis samples detection, we discovered that SDCBP was highly expressed tissues, which correlated clinicopathological features such invasion depth distant metastasis, exhibited heterogeneity across histological or molecular subtypes. Elevated expression promoted the proliferation, migration of cells, modulated epithelial‐mesenchymal transition (EMT) via ERK signaling pathway. Xenograft experiments mice confirmed inhibiting could delay progression. We also found cells knockdown were able to inhibit M2 polarization cocultured macrophages, reduce chemotaxis enhance phagocytosis macrophages. Therefore, plays crucial driving Targeting can partially reverse malignant phenotype, expected be promising for cancer.

Language: Английский

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Comprehensive analysis of stearoyl-coenzyme A desaturase in prostate adenocarcinoma: insights into gene expression, immune microenvironment and tumor progression

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 16, 2024

Prostate adenocarcinoma (PRAD) is a prevalent global malignancy which depends more on lipid metabolism for tumor progression compared to other cancer types. Although Stearoyl-coenzyme A desaturase (SCD) documented regulate in multiple cancers, landscape analysis of its implications PRAD are still missing at present. Here, we conducted an diverse datasets revealing elevated SCD expression the cohort both mRNA and protein levels. Interestingly, was associated with promoter hypermethylation genetic alterations, notably L134V mutation. Integration comprehensive immunological genomic data revealed robust positive correlation between levels abundance CD8 + T cells macrophages. Further analyses identified significant associations various immune markers microenvironment. Single-cell transcriptomic profiling unveiled differential patterns across distinct cell types within prostate The Gene Ontology Kyoto Encyclopedia Genes Genome showed that enriched pathways were primarily related biosynthesis, cholesterol endoplasmic reticulum membrane functions, metabolic pathways. Set Enrichment Analysis highlighted involvement crucial cellular processes, including cycle biosynthesis cofactors In functional studies, overexpression promoted proliferation, metastasis invasion cells, whereas downregulation inhibits these processes. This study provides insights into multifaceted roles pathogenesis, underscoring potential as therapeutic target prognostic biomarker.

Language: Английский

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Tumor-associated macrophages and CD8+ T cells: dual players in the pathogenesis of HBV-related HCC

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 10, 2024

HBV infection is a key risk factor for the development and progression of hepatocellular carcinoma (HCC), highly invasive tumor, characterized by its persistent immunosuppressive microenvironment. This review provides an in-depth analysis HBV-related HCC explores interactions between neutrophils, natural killer cells, dendritic examining their roles in regulating tumor-associated macrophages CD8+ T cells shaping tumor Two critical players milieu are (TAMs). The study how TAMs, initially recruited to combat infection, transform, adopting tumor-promoting phenotype, turning against body, promoting cell proliferation, suppressing anti-tumor immunity, assisting spread cancer. Meanwhile, crucial controlling become dysfunctional exhausted response chronic viral inflammation. then dissects TAMs manipulate this immune response, further depleting functions through mechanisms like arginine deprivation creating hypoxic environments that lead exhaustion. Finally, it challenges promising therapeutic avenues target either separately or combination with antiviral therapy personalized medicine approaches, offering hope improved outcomes HCC.

Language: Английский

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Construction of a prognostic model for ovarian cancer based on a comprehensive bioinformatics analysis of cuproptosis-associated long non-coding RNA signatures

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35004 - e35004

Published: July 23, 2024

Ovarian cancer (OCa) is a common malignancy in women, and the role of cuproptosis its related genes OCa unclear. Using GSE14407 dataset, we analyzed expression correlation cuproptosis-related (CRGs) between tumor normal groups. From TCGA-OV identified 20 long non-coding RNAs (CuLncs) associated with patient survival through univariate Cox analysis. patients were divided into early-stage late-stage groups to analyze CuLncs expression. Cluster analysis classified two clusters, Cluster1 having poorer prognosis. Significant differences "Lymphatic Invasion" "Cancer status" observed clusters. Seven CRGs showed significant differences, validated using human protein atlas (HPA) databases. Immune revealed higher ImmuneScore Cluster1. GSEA signaling pathways. LASSO regression included 11 construct validate prediction model, classifying high-risk low-risk Correlations riskScore, phenotype, ImmuneScore, immune cell infiltration explored. Cell experiments that knocking down AC023644.1 decreases viability. In conclusion, constructed an accurate prognostic model for based on CuLncs, providing basis prognosis assessment potential immunotherapy targets.

Language: Английский

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Exploring SSR1 as a novel diagnostic and prognostic biomarker in hepatocellular carcinoma, and its relationship with immune infiltration

Translational Cancer Research, Journal Year: 2024, Volume and Issue: 13(10), P. 5278 - 5299

Published: Oct. 1, 2024

Although signal sequence receptor subunit 1 (SSR1) has undergone thorough examination in different cancer types, its importance hepatocellular carcinoma (HCC) remains largely uncharted and warrants further investigation. The aim of this study is to explore the role SSR1 HCC progression decipher underlying molecular mechanisms.

Language: Английский

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