Ferroptosis in the adjuvant treatment of lung cancer-the potential of selected botanical drugs and isolated metabolites DOI Creative Commons

Xiaoyan Tian,

Kunling Fu,

Xuemin Huang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 13, 2024

Ferroptosis represents a distinct form of cell death that is not associated with necrosis, autophagy, apoptosis, or pyroptosis. It characterised by intracellular iron-dependent lipid peroxidation. The current literature indicates number botanical drugs and isolated metabolites can modulate ferroptosis, thereby exerting inhibitory effects on lung cancer cells animal models. aim this review to elucidate the mechanisms through which regulate ferroptosis in context cancer, providing potential insights into treatment. crucial highlight these preclinical findings should be interpreted as evidence treatments immediately translated clinical applications. In future, we will continue study pharmacology, pharmacokinetics toxicology drugs, well evaluating their efficacy safety trials, new approaches development agents for treatment cancer.

Language: Английский

Ferroptosis in the adjuvant treatment of lung cancer-the potential of selected botanical drugs and isolated metabolites DOI Creative Commons

Xiaoyan Tian,

Kunling Fu,

Xuemin Huang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 13, 2024

Ferroptosis represents a distinct form of cell death that is not associated with necrosis, autophagy, apoptosis, or pyroptosis. It characterised by intracellular iron-dependent lipid peroxidation. The current literature indicates number botanical drugs and isolated metabolites can modulate ferroptosis, thereby exerting inhibitory effects on lung cancer cells animal models. aim this review to elucidate the mechanisms through which regulate ferroptosis in context cancer, providing potential insights into treatment. crucial highlight these preclinical findings should be interpreted as evidence treatments immediately translated clinical applications. In future, we will continue study pharmacology, pharmacokinetics toxicology drugs, well evaluating their efficacy safety trials, new approaches development agents for treatment cancer.

Language: Английский

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