The gut microbiome in patients with Cushing’s disease affects depression- and anxiety-like behavior in mice DOI Creative Commons

Ding Nie,

Dawei Wang, Zhenhua Wang

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Nov. 1, 2024

Depression and anxiety significantly impact the quality of life in individuals with Cushing's disease (CD), which originates from pituitary neuroendocrine tumors (PitNETs), yet our understanding underlying mechanisms is limited. There substantial evidence linking gut microbes to depression, anxiety, endocrinology.

Language: Английский

Circulating B vitamins metabolites in depressive disorders - connections with the microbiota-gut-brain axis DOI

Wiktor Śliwiński,

Oliwia Gawlik-Kotelnicka

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 472, P. 115145 - 115145

Published: July 9, 2024

Language: Английский

Citations

10
Chronic restraint stress affects the diurnal rhythms of gut microbial composition and metabolism in a mouse model of depression DOI Creative Commons
Yue Wang,

Peijin Cui,

Maolin Cao

et al.

BMC Microbiology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 22, 2025

Depression is a common mental disorder accompanied by gut microbiota dysbiosis, which disturbs the metabolism of host. While diurnal oscillation intestinal involved in regulating host metabolism, characteristics microbial circadian rhythm depression remain unknown. Our aim was to investigate signature and related metabolic pathways mouse model with depression-like behaviours. Chronic restraint stress (CRS) used induce depressive-like behaviours C57BL/6J mice. The open field test (OFT) forced swimming (FST) were evaluate anxiety- control CRS groups. Afterwards, faecal samples from two groups collected every four hours ZT2 (9:00 am) ZT22 (5:00 am). Faecal 16 S rRNA gene sequencing metabolomics analysis performed, analysed via MetaCycle package R/RStudio. mice exhibited after 4 weeks restriction. Alpha- beta-diversity analyses revealed that composition oscillated throughout day. at phylum level, Bacteroidota, Firmicutes, Cyanobacteria Patescibacteria showed rhythmicity group. At genus Dubosiella Romboutsia group, abundance correlated tryptophan galactose metabolism. In Bacteroides, Parabacteroides, Rikenellaceae_RC9_gut_group rhythmicity; among these genera, Parabacteroides axon regeneration, phenylalanine tyrosine data highlight importance observing microbiome states. Rhythmicity may affect distinct during light dark phases. A better combination would help offer novel insight into key genera their potential effects on depression.

Language: Английский

Citations

0
Seeds for Gut Health: Prebiotic potential of seed mucilages from Chia, Fenugreek, Basil, Mustard, and Flaxseed and their impact on adult and toddler's gut microbiome DOI Creative Commons
Kanika Mahra, Vineet Singh,

Justina Klingate

et al.

Future Foods, Journal Year: 2025, Volume and Issue: unknown, P. 100628 - 100628

Published: April 1, 2025

Language: Английский

Citations

0
The gut microbiome in patients with Cushing’s disease affects depression- and anxiety-like behavior in mice DOI Creative Commons

Ding Nie,

Dawei Wang, Zhenhua Wang

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Nov. 1, 2024

Depression and anxiety significantly impact the quality of life in individuals with Cushing's disease (CD), which originates from pituitary neuroendocrine tumors (PitNETs), yet our understanding underlying mechanisms is limited. There substantial evidence linking gut microbes to depression, anxiety, endocrinology.

Language: Английский

Citations

1