Recent Treatment Strategies and Molecular Pathways in Resistance Mechanisms of Antiangiogenic Therapies in Glioblastoma

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 2975 - 2975

Published: Aug. 27, 2024

Malignant gliomas present great difficulties in treatment, with little change over the past 30 years median survival time of 15 months. Current treatment options include surgery, radiotherapy (RT), and chemotherapy. New therapies aimed at suppressing formation new vasculature (antiangiogenic treatments) or destroying formed tumor (vascular disrupting agents) show promise. This study summarizes existing knowledge regarding processes by which glioblastoma (GBM) tumors acquire resistance to antiangiogenic treatments. The discussion encompasses activation redundant proangiogenic pathways, heightened cell invasion metastasis, induced hypoxia, creation vascular mimicry channels, regulation immune microenvironment. Subsequently, we explore potential strategies overcome this resistance, such as combining other methods, personalizing treatments for each patient, focusing on therapeutic targets, incorporating immunotherapy, utilizing drug delivery systems based nanoparticles. Additionally, would like discuss limitations methods future directions enhance beneficial effects patients GBM. Therefore, review aims research outcome GBM provide a more promising opportunity thoroughly exploring mechanisms investigating novel strategies.

Language: Английский

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Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities

Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 701 - 701

Published: Feb. 19, 2025

Glioblastoma multiforme (GBM) is a highly malignant brain tumor that has bleak outlook despite existing treatments such as surgery, radiation, and chemotherapy. The utilization of nanoparticles for drug delivery presents promising method by which to improve the effectiveness treatment while reducing harmful effects on entire body. This review examines application in GBM, focusing different types nanoparticles, including lipid-based, polymeric, metallic, those under development. Every variety analyzed its distinct characteristics therapeutic capacity. Lipid-based liposomes solid lipid enhance transport medicines are not soluble water have shown considerable potential preclinical investigations. Polymeric benefits terms controlled release targeted distribution, whereas metallic both therapy imaging. In current we would like emphasize ways medicine delivery, specifically enhancing penetration blood-brain barrier (BBB), targeting tumors, enabling release. Additionally, also discuss clinical discoveries, highlighting achievements obstacles process converting these technologies into effective GBM. study offers thorough examination present status prospects

Language: Английский

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State-of-the-art photodynamic therapy for malignant gliomas: innovations in photosensitizers and combined therapeutic approaches

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Glioblastoma (GBM), the most aggressive and lethal primary brain tumor, poses a significant therapeutic challenge due to its highly invasive nature resistance conventional therapies, including surgery, chemotherapy, radiotherapy. Despite advances in standard treatments, patient survival remains limited, requiring exploration of innovative strategies. Photodynamic therapy (PDT) has emerged as promising approach, leveraging light-sensitive photosensitizers (PSs), molecular oxygen, specific light wavelengths generate reactive oxygen species (ROS) that selectively induce tumor cell death. Originally developed for skin cancer, PDT evolved target more complex malignancies, GBM. The refinement second- third-generation PS, coupled with advancements nanotechnology, significantly improved PDT's selectivity, bioavailability, efficacy. Moreover, combination targeted therapy, immunotherapy, among other modalities, shown potential enhancing outcomes. This review provides comprehensive analysis preclinical clinical applications GBM, detailing mechanisms action, evolution novel combinatory strategies optimize treatment However, several challenges remain, overcoming GBM-associated hypoxia, PS delivery across blood-brain barrier, mitigating mechanisms. integration genetic insight, alongside cutting-edge nanotechnology-based systems, may revolutionize GBM treatment, offering new prospects quality life.

Language: Английский

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Possible mechanisms underlying the neuroprotective effects of gold nanoparticles and alpha-lipoic acid mixture on brain damage induced by radiation: A subacute study in rats

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106977 - 106977

Published: April 1, 2025

Language: Английский

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Advances in nanoparticle-based radiotherapy for cancer treatment

iScience, Journal Year: 2024, Volume and Issue: 28(1), P. 111602 - 111602

Published: Dec. 14, 2024

Language: Английский

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