International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2695 - 2695
Published: March 17, 2025
Biofilm-associated
amyloid
proteins
have
emerged
as
significant
contributors
to
the
progression
of
neurodegenerative
diseases,
representing
a
complex
intersection
microorganisms
and
human
health.
The
cross-beta
sheet
structure
characteristic
amyloids
produced
by
gut-colonizing
bacteria
remains
intact,
crucial
for
resilience
biofilms.
These
exacerbate
disorders
such
Alzheimer’s
Parkinson’s
cross-seeding
amyloidogenic
like
amyloid-beta
α-synuclein,
accelerating
their
misfolding
aggregation.
Despite
molecular
chaperones
heat
shock
maintaining
protein
homeostasis,
bacterial
can
overwhelm
them,
worsening
neuronal
damage.
Genetic
variations
in
chaperone
genes
further
influence
amyloidogenesis
neurodegeneration.
Persistent
infections
inflammation
compromise
blood-brain
barrier,
allowing
inflammatory
molecules
enter
brain,
perpetuating
cycle
gut-brain
axis
underscores
impact
dysbiosis
gut
microbiota
on
brain
function,
potentially
contributing
enhancement
biofilm
antibiotic
resistance
functional
fibrils
complicates
treatment
landscape.
interplay
among
systems,
microbial
amyloids,
diseases
urgent
need
advanced
strategies
targeting
these
pathways
attenuate
disease
progression.
Understanding
processes
that
relate
biofilm-associated
onset
neurological
is
critical
diagnosing
developing
novel
strategies.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(10), P. 1330 - 1330
Published: Oct. 19, 2024
Currently,
the
age
structure
of
world
population
is
changing
due
to
declining
birth
rates
and
increasing
life
expectancy.
As
a
result,
physicians
worldwide
have
treat
an
number
age-related
diseases,
which
neurological
disorders
represent
significant
part.
In
this
context,
there
urgent
need
discover
new
therapeutic
approaches
counteract
effects
neurodegeneration
on
human
health,
computational
science
can
be
pivotal
importance
for
more
effective
neurodrug
discovery.
The
knowledge
molecular
receptors
other
biomolecules
involved
in
pathogenesis
facilitates
design
molecules
as
potential
drugs
used
fight
against
diseases
high
social
relevance
such
dementia,
Alzheimer's
disease
(AD)
Parkinson's
(PD),
cite
only
few.
However,
absence
comprehensive
guidelines
regarding
strengths
weaknesses
alternative
creates
fragmented
disconnected
field,
resulting
missed
opportunities
enhance
performance
achieve
successful
applications.
This
review
aims
summarize
some
most
innovative
strategies
based
methods
development.
particular,
recent
applications
state-of-the-art
docking
artificial
intelligence
ligand-
target-based
novel
drug
were
reviewed,
highlighting
crucial
role
silico
context
discovery
neurodegenerative
diseases.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2025,
Volume and Issue:
24(2)
Published: Feb. 3, 2025
Abstract
With
the
exacerbation
of
global
population
aging,
age‐related
neurodegenerative
disorders
have
been
posing
an
increasing
public
health
concern.
l
‐α‐Glycerylphosphorylcholine
(
‐α‐GPC)
has
demonstrated
significant
therapeutic
potential
for
mental
health‐related
and
possesses
promising
market
prospects.
Recently,
‐α‐GPC
successively
approved
as
a
new
food
resource
in
Canada
(2023)
China
(2024).
These
policies
pointed
out
recognized
safety
utility
‐α‐GPC.
The
utilization
dietary
supplements
foods
could
be
convenient
option
early
intervention
strategies
to
potentially
delay
or
mitigate
progression
disorders.
Additionally,
other
unique
nutritional
benefits
highlighted,
further
expanding
its
application
industry.
Encouraged
by
policy
incentives,
there
is
likely
upsurge
research
interest
surrounding
To
fully
capitalize
on
these
emerging
opportunities,
we
present
comprehensive
review
chemical
properties,
pharmacological
characteristics,
assessments,
preparation
methods
were
summarized.
A
brief
outlook
future
perspectives
unsolved
challenges
was
also
proposed.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 6, 2025
Abstract
Expression
of
the
N-methyl-D-aspartate
receptor,
particularly
when
containing
GluN2B
subunit
(NMDAR-GluN2B)
varies
across
prefrontal
cortex
(PFC).
In
humans,
subgenual
cingulate
(SGC)
contains
among
highest
levels
NMDAR-GluN2B
expression,
while
dorsolateral
(dlPFC)
exhibits
a
more
moderate
level
expression.
are
commonly
associated
with
ionotropic
synaptic
function
and
plasticity,
essential
to
neurotransmission
underlying
working
memory
in
macaque
dlPFC
layer
III
circuits
afflicted
schizophrenia.
However,
can
also
be
found
at
extrasynaptic
sites,
where
they
may
trigger
distinct
events,
including
some
linked
neurodegenerative
processes.
The
SGC
is
an
early
site
tau
pathology
sporadic
Alzheimer’s
Disease
(sAD),
which
mirrors
its
high
Additionally,
hyperactive
depression,
treated
NMDAR
antagonists.
Given
clinical
relevance
dlPFC,
current
study
used
immunoelectron
microscopy
(immunoEM)
quantitatively
compare
expression
patterns
excitatory
inhibitory
neuron
dendrites
rhesus
dlPFC.
We
larger
population
dendritic
shafts
spines
putative
pyramidal
neurons
as
compared
had
higher
proportion
NMDAR-GluN2B.
contrast,
from
both
areas,
was
far
frequently
observed
over
These
findings
provide
insight
into
varying
cortical
vulnerability
alterations
excitability
forces.
Scope
Statement
receptors
that
contribute
second
messenger
signaling
events.
induce
diverse
array
neuronal
part
due
variation
composition
subcellular
localization
receptor
humans.
This
highly
expressed
cingulate,
area
mood
emotion,
moderately
cortex,
cognitive
Extrasynaptic
NMDAR,
often
contain
subunit,
have
been
detrimental
cellular
events
like
neurodegeneration.
Here,
using
resolution
electron
macaques,
we
evidence
prominent
than
cortex.
Conversely,
consistent
their
contribution
firing
during
memory.
help
illuminate
propensity
tonic
hyperactivity
major
depression
neurodegeneration
disease,
explain
how
rapid
acting
antidepressants
exert
therapeutic
action
neural
circuits.
Cureus,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 9, 2025
Background
Holistic
medical
practices,
including
meditation
and
mindfulness,
are
increasingly
recognized
for
their
benefits
in
mental
health
stress
reduction,
with
applications
clinical
settings.
However,
effects
on
older
adults
mild
cognitive
impairment
(MCI)
remain
underexplored.
This
study
aimed
to
evaluate
the
impact
of
loosening
meditation,
a
brief
accessible
practice
we
developed,
this
population.
Methods
Nine
MCI,
defined
by
Mini-Mental
State
Examination
(MMSE)
scores
21-28
during
screening
period,
participated
pilot
study.
The
sessions
our
were
conducted
weekly
over
four
weeks.
Cognitive
function
was
assessed
using
MMSE
Revised
Hasegawa's
Dementia
Scale
(HDS-R),
while
psychological
well-being
evaluated
30-item
General
Health
Questionnaire
(GHQ-30)
Japanese
version
University
Wales
Institute
Science
Technology
Mood
Adjective
Checklist
(JUMACL).
Serum
levels
representative
biomarkers
measured
before
after
first
session.
Results
Participants
had
mean
age
78.1
years
(±
4.8
years)
score
25.1
points
2.5).
These
participants
could
complete
all
safely.
No
significant
differences
observed
MMSE,
HDS-R,
GHQ-30,
or
JUMACL
(tension
arousal)
intervention.
(emotion
significantly
improved
fourth
session
(pre-first,
25.3
±
6.2;
post-fourth,
28.7
7.3;
p
=
0.004).
Among
these
biomarkers,
serum
cortisol
decreased
following
(before
versus
after,
10.8
5.8
7.4
2.3
μg/dl;
0.04).
Additionally,
although
not
statistically
significant,
there
trend
towards
lower
level
adrenaline
0.057
0.026
0.050
0.027
ng/ml;
0.06).
Conclusions
Our
feasible,
acceptable,
safe,
might
enhance
mood
reduce
even
MCI.
preliminary
findings
suggest
its
potential
as
supportive
intervention
