The ability of Ibutropin to blunt fentanyl-induced respiratory depression is independent of its activation of carotid body chemoafferents DOI Creative Commons

Paulina M. Getsy,

Walter J. May,

Gregory A. Coffee

et al.

Journal of Pharmacology and Experimental Therapeutics, Journal Year: 2024, Volume and Issue: 392(2), P. 100060 - 100060

Published: Dec. 10, 2024

This study examined the effects of intravenous injection isobutyric tropine ester (Ibutropin) on ventilation in freely-moving sham-operated (SHAM) male Sprague Dawley rats and those with bilateral carotid sinus nerve transection (CSNX). also a subsequent fentanyl ventilatory parameters both groups rats. Ibutropin (200 μmol/kg, i.v.) elicited rapid pronounced increases breathing frequency, tidal volume, minute ventilation, peak inspiratory expiratory flows, drives SHAM rats, but substantially smaller responses CSNX The (75 μg/kg, similar Ibutropin-treated markedly different changes end-inspiratory end-expiratory pauses, delay, apneic pause. Moreover, fentanyl-induced were than that pre-injected vehicle (saline) rather Ibutropin. These novel findings suggest acts at body-chemoafferent complex to drive by mechanisms may involve entry this cell-permeant into chemoafferent terminals and/or primary glomus cells. A key finding was ability blunt adverse does not require functional body chemoreceptor afferent input brainstem structures controlling breathing. As such, greatly diminish actions within central respiratory control centers peripheral other bodies. SIGNIFICANCE STATEMENT: revealed depressant present

Language: Английский

Isobutyric tropine ester (Ibutropin) overcomes fentanyl-induced respiratory depression in unanesthetized rats without compromising analgesia DOI Creative Commons

Paulina M. Getsy,

Walter J. May,

Alex P. Young

et al.

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110479 - 110479

Published: April 1, 2025

Language: Английский

Citations

0
The ability of Ibutropin to blunt fentanyl-induced respiratory depression is independent of its activation of carotid body chemoafferents DOI Creative Commons

Paulina M. Getsy,

Walter J. May,

Gregory A. Coffee

et al.

Journal of Pharmacology and Experimental Therapeutics, Journal Year: 2024, Volume and Issue: 392(2), P. 100060 - 100060

Published: Dec. 10, 2024

This study examined the effects of intravenous injection isobutyric tropine ester (Ibutropin) on ventilation in freely-moving sham-operated (SHAM) male Sprague Dawley rats and those with bilateral carotid sinus nerve transection (CSNX). also a subsequent fentanyl ventilatory parameters both groups rats. Ibutropin (200 μmol/kg, i.v.) elicited rapid pronounced increases breathing frequency, tidal volume, minute ventilation, peak inspiratory expiratory flows, drives SHAM rats, but substantially smaller responses CSNX The (75 μg/kg, similar Ibutropin-treated markedly different changes end-inspiratory end-expiratory pauses, delay, apneic pause. Moreover, fentanyl-induced were than that pre-injected vehicle (saline) rather Ibutropin. These novel findings suggest acts at body-chemoafferent complex to drive by mechanisms may involve entry this cell-permeant into chemoafferent terminals and/or primary glomus cells. A key finding was ability blunt adverse does not require functional body chemoreceptor afferent input brainstem structures controlling breathing. As such, greatly diminish actions within central respiratory control centers peripheral other bodies. SIGNIFICANCE STATEMENT: revealed depressant present

Language: Английский

Citations

1