Cerebrovascular accident and essential and toxic metals: cluster analysis and principal component analysis DOI Creative Commons

Hossein Nezami,

Alireza Kooshki,

Habibollah Esmaily

et al.

BMC Pharmacology and Toxicology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 2, 2025

Cerebrovascular accidents are known as a great cause of morbidity and mortality worldwide. Although there risk factors for ischemic stroke, the cases that cannot be justified with these increasing. Toxic metals potential factor other diseases in humans assessed this study CVA group compared to controls. 70 participants (35 each group) have been selected study. The recent medical history documented control non-CVA group. serum level several has using Inductively coupled plasma mass spectrometry (ICP-MS) method. principal components cluster analyses were employed compare toxic metal toxicity between groups. Cu (p < 0.001) Pb = 0.002) levels significantly higher whereas Ni (0.003) lower. There was no significant difference smoking 0.56) opium 0.46) use Most essential positively correlated both groups (Ni Fe, Zn; Fe Zn r over 0.6). also PCA CA crucial analysis which Ni, most similarly we found complex interaction healthy human body. Due lack data on vivo even individuals, further investigation is needed evaluate exact mechanism such relations.

Language: Английский

Cerebrovascular accident and essential and toxic metals: cluster analysis and principal component analysis DOI Creative Commons

Hossein Nezami,

Alireza Kooshki,

Habibollah Esmaily

et al.

BMC Pharmacology and Toxicology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 2, 2025

Cerebrovascular accidents are known as a great cause of morbidity and mortality worldwide. Although there risk factors for ischemic stroke, the cases that cannot be justified with these increasing. Toxic metals potential factor other diseases in humans assessed this study CVA group compared to controls. 70 participants (35 each group) have been selected study. The recent medical history documented control non-CVA group. serum level several has using Inductively coupled plasma mass spectrometry (ICP-MS) method. principal components cluster analyses were employed compare toxic metal toxicity between groups. Cu (p < 0.001) Pb = 0.002) levels significantly higher whereas Ni (0.003) lower. There was no significant difference smoking 0.56) opium 0.46) use Most essential positively correlated both groups (Ni Fe, Zn; Fe Zn r over 0.6). also PCA CA crucial analysis which Ni, most similarly we found complex interaction healthy human body. Due lack data on vivo even individuals, further investigation is needed evaluate exact mechanism such relations.

Language: Английский

Citations

1