Effects of dietary acrylamide on kidney and liver health: Molecular mechanisms and pharmacological implications DOI Creative Commons

Mohammed Nazish Quasmi,

Dinesh Kumar, Ashok Jangra

et al.

Toxicology Reports, Journal Year: 2024, Volume and Issue: 14, P. 101859 - 101859

Published: Dec. 10, 2024

Acrylamide (AA) has raised concerns throughout the world in recent years because of its potential negative effects on human health. Numerous researches humans and animals have connected a high dietary exposure to AA possible risk cancer. Additionally, higher consumption acrylamide also been associated with dysfunctioning various organ systems from nervous system reproductive system. is primarily metabolised into glycidamide inside body which gets accumulated different tissues including kidney liver, chronic this can lead nephrotoxicity hepatotoxicity through molecular mechanisms. This review summarizes sources, formation metabolism along mechanisms such as oxidative stress, inflammation, DNA damage, autophagy, mitochondrial dysfunction morphological changes nephron hepatocytes exerts deleterious effect liver causing hepatotoxicity. animal cellular studies that demonstrate AA-induced Lastly, article emphasizes underlying protective pharmacological interventions against induced nephrotoxicity.

Language: Английский

Determination of Acrylamide levels in chips/crisps on the Italian market and Exposure Risk Assessment DOI
Antonio Cristaldi, Eloise Pulvirenti, Paola Rapisarda

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115539 - 115539

Published: May 1, 2025

Language: Английский

Citations

0
Effects of dietary acrylamide on kidney and liver health: Molecular mechanisms and pharmacological implications DOI Creative Commons

Mohammed Nazish Quasmi,

Dinesh Kumar, Ashok Jangra

et al.

Toxicology Reports, Journal Year: 2024, Volume and Issue: 14, P. 101859 - 101859

Published: Dec. 10, 2024

Acrylamide (AA) has raised concerns throughout the world in recent years because of its potential negative effects on human health. Numerous researches humans and animals have connected a high dietary exposure to AA possible risk cancer. Additionally, higher consumption acrylamide also been associated with dysfunctioning various organ systems from nervous system reproductive system. is primarily metabolised into glycidamide inside body which gets accumulated different tissues including kidney liver, chronic this can lead nephrotoxicity hepatotoxicity through molecular mechanisms. This review summarizes sources, formation metabolism along mechanisms such as oxidative stress, inflammation, DNA damage, autophagy, mitochondrial dysfunction morphological changes nephron hepatocytes exerts deleterious effect liver causing hepatotoxicity. animal cellular studies that demonstrate AA-induced Lastly, article emphasizes underlying protective pharmacological interventions against induced nephrotoxicity.

Language: Английский

Citations

0