Unlocking the power of short-chain fatty acids in ameliorating intestinal mucosal immunity: a new porcine nutritional approach DOI Creative Commons

Haoyang Liu,

Hongde Lu,

Yuxuan Wang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 2, 2024

Short-chain fatty acids (SCFAs), a subset of organic with carbon chains ranging from one to six atoms in length, encompass acetate, propionate, and butyrate. These compounds are the endproducts dietary fiber fermentation, primarily catalyzed by glycolysis pentose phosphate pathways within gut microbiota. SCFAs act as pivotal energy substrates signaling molecules realm animal nutrition, exerting profound influence on intestinal, immune system, intestinal barrier functions. Specifically, they contibute 60-70% total requirements ruminants 10-25% monogastric animals. have demonstrated capability effectively modulate pH, optimize absorption mineral elements, impede pathogen invasion. Moreover, enhance expression proteins associated tight junctions stimulate mucus production, thereby refining tissue morphology preserving integrity structure. Notably, also exert anti-inflammatory properties, mitigating inflammation epithelium strengthening barrier’s defensive capabilities. The present review endeavors synthesize recent findings regarding role crucial intermediaries between metabolic activities microbiota status porcine cells. It provides comprehensive overview current literature SCFAs’ impact responses mucosa.

Language: Английский

Mucosal immunity and rheumatoid arthritis: An update on mechanisms and therapeutic potential DOI Creative Commons
Yuchen Yang,

Congmin Xia,

Chuanhui Yao

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: 24(5), P. 103775 - 103775

Published: Feb. 13, 2025

Rheumatoid Arthritis (RA) is a persistent autoimmune inflammatory disorder that arises from the intricate interaction between genetic predisposition and environmental influences. The progression of RA can be delineated into four distinct phases: initially, influence risk factors; followed by emergence systemic autoimmunity; subsequently, an asymptomatic phase; ultimately, manifestation clinical arthritis. Recently, role mucosal immunity in has gained significant attention research. Evidence published studies suggests not only influences onset but also plays crucial its progression. Scholars have begun to unravel links barriers gastrointestinal tract, respiratory system, oral cavity. Specifically, shifts microbiota, dysfunction barriers, abnormal activation immune tissues are all implicated pathogenesis RA.Despite this growing body knowledge, comprehensive review therapeutic implications yet conducted. This emphasizes driving abnormalities development autoimmunity rheumatoid arthritis (RA). It further explores potential RA, as well issues challenges need addressed current research field, providing new perspective targets for prevention treatment RA.

Language: Английский

Citations

1
Exploring the Benefits and Prescribing Informations of Combining East Asian Herbal Medicine with Conventional Medicine in the Treatment of Rheumatoid Arthritis: A Systematic Review and Multifaceted Analysis of 415 Randomized Controlled Trials DOI Creative Commons
Hee-Geun Jo, Jihye Seo, Eunhye Baek

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107616 - 107616

Published: Jan. 1, 2025

Notwithstanding progress in conventional medicine (CM), the management of rheumatoid arthritis (RA) continues to be problematic due factors such as limited patient response treatment and restricted medication access. This study aimed evaluate extent which East Asian herbal with CM combination therapy (EACM) provides additional benefits effectiveness safety. We conducted a comprehensive search across 11 databases English, Chinese, Korean, Japanese for randomized controlled trials. The review followed Preferred Reporting Items Systematic Reviews Meta-Analyses guidelines, using American College Rheumatology (ACR) 20/50/70 Response Criteria incidence adverse events (AEI) primary outcomes. meta-analysis was performed random-effects model. quality each assessed according RoB 2. Of 1,036 full-text articles screened, 415 were included review. data from 37,839 participants. EACM associated higher ACR responses: 20 (RR: 1.2332; 95% CI: 1.1852 1.2831, p < 0.0001), 50 1.3782; 1.2936 1.4684, 70 1.7084; 1.5555 1.8762, well favorable AEI (OR: 0.3977; 0.3476 0.4551, indicating both better efficacy safety compared alone. These patterns consistent eight secondary outcomes measuring pain, inflammation, disease activity RA. Subgroup analyses showed that EACM's effects independent control type. Through analysis polyherbal prescription dataset, we identified 18 key herbs 16 significant rules, further supported by relevant preclinical evidence. synergistic combinations anticipated most pharmacologically influential contributing outcomes, substantiated analytical metrics including network topology intricate association pattern evaluations. findings suggest may serve valuable complementary strategy RA patients insufficiently managed In particular, given index integrates multiple aspects patients, results are expected provide decision support who do not respond therapy, medical economic reasons. Additionally, derived through multifaceted analysis, actively reflect clinicians' implicit preferences prescribing EACMs, important hypotheses research clinical application. However, qualitative quantitative improvements needed more definitive conclusions. Further prescriptions presented this will direction future research.

Language: Английский

Citations

0
Chemical composition and in vitro intestinal probiotic properties analysis of exopolysaccharides from screened Streptococcus thermophilus 90301 DOI
Xiaochan Wang, Tao Lin, Yihan Lin

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143882 - 143882

Published: May 2, 2025

Language: Английский

Citations

0
Unlocking the power of short-chain fatty acids in ameliorating intestinal mucosal immunity: a new porcine nutritional approach DOI Creative Commons

Haoyang Liu,

Hongde Lu,

Yuxuan Wang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 2, 2024

Short-chain fatty acids (SCFAs), a subset of organic with carbon chains ranging from one to six atoms in length, encompass acetate, propionate, and butyrate. These compounds are the endproducts dietary fiber fermentation, primarily catalyzed by glycolysis pentose phosphate pathways within gut microbiota. SCFAs act as pivotal energy substrates signaling molecules realm animal nutrition, exerting profound influence on intestinal, immune system, intestinal barrier functions. Specifically, they contibute 60-70% total requirements ruminants 10-25% monogastric animals. have demonstrated capability effectively modulate pH, optimize absorption mineral elements, impede pathogen invasion. Moreover, enhance expression proteins associated tight junctions stimulate mucus production, thereby refining tissue morphology preserving integrity structure. Notably, also exert anti-inflammatory properties, mitigating inflammation epithelium strengthening barrier’s defensive capabilities. The present review endeavors synthesize recent findings regarding role crucial intermediaries between metabolic activities microbiota status porcine cells. It provides comprehensive overview current literature SCFAs’ impact responses mucosa.

Language: Английский

Citations

1