Cited by Review to Elucidate the Correlation between Cuproptosis-Related Genes and Immune Infiltration for Enhancing the Detection and Treatment of Cervical Cancer

Review to Elucidate the Correlation between Cuproptosis-Related Genes and Immune Infiltration for Enhancing the Detection and Treatment of Cervical Cancer DOI

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10604 - 10604

Published: Oct. 1, 2024

Copper is a vital trace element in oxidized and reduced forms. It plays crucial roles numerous biological events such as redox chemistry, enzymatic reactions, mitochondrial respiration, iron metabolism, autophagy, immune modulation. Maintaining the balance of copper body essential because its deficiency excess can be harmful. Abnormal metabolism has two-fold impact on development tumors cancer treatment. Cuproptosis form cell death that occurs when there excessive body, leading to proteotoxic stress activation specific pathway mitochondria. Research been conducted advantageous role ionophores chelators management. This review presents recent progress understanding cuproptosis, molecular mechanisms involved using for targeted therapy cervical cancer. Integrating metals minerals into nanoparticulate systems promising approach controlling invasive tumors. Therefore, we have also included concise overview nanoformulations targeting cells. offers comprehensive insights correlation between cuproptosis-related genes infiltration, well prognosis These findings valuable developing advanced clinical tools enhance detection treatment

Language: Английский

Tumor Microenvironment-Responsive Lipid Peroxidation Amplifier: Harnessing Ferroptosis Resistance to Devastate the Ferroptosis Defense System DOI

Youhui Zeng,

Jinfeng Yang, Zhen Gu

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Amplification of lipid peroxidation with tumor specificity represents a new avenue to boost ferroptosis-mediated anticancer therapeutics but remains challenging. Herein, we proposed metal-phenolic-network (MPN)-coated nanohybrid as microenvironment-responsive amplifier, consisting reactive oxygen species generator MPN, glutathione (GSH) scavenger GSH-P, and peroxidase 4 (GPX4) mRNA gene silencing sequence. The protective MPN shell this amplifier can be specifically disintegrated by acidic adenosine triphosphate (ATP)-rich microenvironments induce oxidative stress through the dual disruption redox homeostasis (Fenton-catalytic accumulation GSH depletion). Furthermore, stress-induced upregulation ferroptosis resistance-related apurinic/apyrimidinic endonuclease 1 (APE1) is further ingeniously employed an amplification element prompt release (AP) site-embedded GPX4 sequence which downregulate level. Based on tandem depletion substrate GPX4, defense system GPX4/GSH heavily devastated enable for effectively improving efficiency. We expect strategy expanded other important regulatory proteins provide mechanism study therapy.

Language: Английский

Citations

Ferroptosis as the new approach to Cancer therapy DOI