Effectiveness and safety of acupuncture for melasma: A meta-analysis of randomized controlled trials

EXPLORE, Journal Year: 2025, Volume and Issue: 21(1), P. 103108 - 103108

Published: Jan. 1, 2025

Treating melasma remains challenging. We conducted a meta-analysis to assess the effectiveness and safety of acupuncture as treatment option. searched three English four Chinese databases up January 2, 2024. The primary outcome was total effective rate, while secondary outcomes included skin lesion area color scores, score, adverse effects. Study quality assessed using risk bias tool, data were analyzed with Review Manager 5.4. GRADE approach evaluated evidence certainty. This study 22 studies 1644 participants. Findings indicate that significantly outperforms Western medicine other treatments (risk ratio [RR] = 1.21, 95 % confidence interval [CI] (1.18, 1.30), P < 0.00001, I² 34 %). Acupuncture effectively reduces lesions (mean difference [MD] -0.35, CI (-0.52, -0.19), 0.0001, 93 %), lightens (MD -0.45, (-0.58, -0.31), 89 lowers score -1.00, (-1.29, -0.70), 79 Adverse reactions infrequent acupuncture. most common needling sites in facial area, noted 17 studies. Sanyinjiao (SP6) frequently used acupoint (n 8), followed by Hegu (LI4) 7) Xuehai (SP10) 7). Other commonly acupoints Tianshu (ST25), Zusanli (ST36), Taichong (LR3), Zhongwan (RN12). All outcomes, except for outcome, rated very low quality. review confirms therapy scores. appears be safe option melasma; however, results should interpreted cautiously due potential publication regional biases. CRD42024503394.

Language: Английский

Small-Molecule Tyrosinase Inhibitors for Treatment of Hyperpigmentation

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 788 - 788

Published: Feb. 8, 2025

Increasing attention is being focused on skin health currently, especially the excessive deposition of melanin in skin. Tyrosinase, rate-limiting enzyme biosynthesis, a crucial synthesis. However, existing tyrosinase inhibitors pose some degree toxicity to humans. Therefore, development more efficient and low-toxicity urgently needed. This review briefly depicts biosynthesis process crystal structure catalytic mechanism tyrosinase. The latest research progress regarding small-molecule also reviewed. Moreover, structure-function relationships are analyzed summarized. expected provide new scientific insights enable researchers explore safer potent inhibitors.

Language: Английский

Clinical Efficacy of CGF Combined With Periodic Supramolecular Salicylic Acid in the Treatment of Chloasma

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(4)

Published: March 26, 2025

ABSTRACT Objective To investigate the clinical efficacy of CGF combined with supramolecular salicylic acid cycle injection for melasma. Methods Twenty patients chloasma admitted to our hospital were selected and treated facial injection. After each injection, was given once. one treatment, severity melasma skin parameters before after treatment compared using modified Area Severity index (MASI) VISIA image analysis system, respectively. At same time, patients' self‐satisfaction investigated. Results The total effective rate in 95%. Compared scores spots, UV brown red areas, wrinkles, texture, pore porphyrins significantly increased treatment. MASI score reduced (4.70 ± 2.47 vs. 15.30 4.01, p < 0.001). results showed that satisfaction improvement 95.00%. Conclusion has an obvious effect on comprehensive overall aging patients, can effectively accelerate speed lesion repair pigment elimination, which is worthy promotion application.

Language: Английский