Andrographolide prevents necroptosis by suppressing the generation of reactive oxygen species DOI Creative Commons
Na Lu, Qing Li, Linghan Duan

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Development and validation of an automatic machine learning model to predict abnormal increase of transaminase in valproic acid-treated epilepsy DOI
Hongying Ma, Sihui Huang, Fengxin Li

et al.

Archives of Toxicology, Journal Year: 2024, Volume and Issue: 98(9), P. 3049 - 3061

Published: June 16, 2024

Language: Английский

Citations

6
Lithospermic acid alleviates oxidative stress and inflammation in DSS-induced colitis through Nrf2 DOI

Yu-Lei Zhao,

Xue Tian, Yan Yao

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177390 - 177390

Published: Feb. 1, 2025

Language: Английский

Citations

0
NUDT1 aggravates intestinal epithelial barrier injury through oxidative stress in ulcerative colitis DOI
Guiyuan Jin,

Xizhuang Gao,

Fengxian Dai

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114634 - 114634

Published: April 10, 2025

Language: Английский

Citations

0
Andrographolide Sulfonates and Xiyanping: A Review of Chemical Composition, Pharmacological Activities, Clinical Applications, and Adverse Reactions DOI Creative Commons
Zihong Li, Lihao Yao, Zhenjie Liu

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 183 - 183

Published: Jan. 29, 2025

Andrographis paniculata is a plant of the Acanthaceae family and its primary bioactive constituent, andrographolide, exhibits broad spectrum pharmacological activities notable clinical efficacy. However, poor solubility limited bioavailability pose significant challenges for therapeutic applications. To overcome these limitations, researchers have synthesized andrographolide sulfonates by reacting with ethanol sulfuric acid. This sulfonated derivative significantly enhances water while retaining key properties such as anti-inflammatory antiviral activities. As representative formulation, Xiyanping injection has been widely employed in treatment respiratory infections, pneumonia, related conditions, playing critical role during COVID-19 pandemic. Despite widespread application, there yet to be comprehensive review chemical composition mechanisms. Additionally, safety remains topic some debate. systematically examines composition, activities, applications, adverse reactions their formulation provide scientific basis further research also offering valuable insights development similar drugs.

Language: Английский

Citations

0
Andrographolide ameliorates sepsis-induced acute liver injury by attenuating endoplasmic reticulum stress through the FKBP1A-mediated NOTCH1/AK2 pathway DOI Creative Commons
Jiaqi He,

Zepeng Huang,

Rui Zou

et al.

Cell Biology and Toxicology, Journal Year: 2025, Volume and Issue: 41(1)

Published: March 7, 2025

Andrographolide (AP) has been shown to possess anti-inflammatory activities. In this study, the impact of AP in sepsis-induced acute liver injury (ALI) and molecules involved were dissected. FKBP1A was predicted be sole target protein that also differentially expressed GSE166868 dataset. induced expression suppressed NOTCH1 a dose-dependent manner. ameliorated ALI mice by D-galactosamine LPS inhibited LPS-induced parenchymal cell vitro. By contrast, protective effect significantly lost after knockdown FKBP1A. As positive control, therapeutic dexamethasone on may related NOTCH1, which not promoted AK2 transcription cells, endoplasmic reticulum (ER) stress impairing NOTCH1/AK2 signaling. Restoration reversed hepatoprotective activating ER pathway. Therefore, AP-promoted inhibits progression blocking NOTCH1/AK2-mediated

Language: Английский

Citations

0
An integrated network pharmacology and metabolomics approach reveals the mechanism of action of Andrographis paniculata and Senecio scandens in ameliorating dextran sulfate sodium-induced ulcerative colitis in mice DOI Creative Commons
Caihong Li, Lu Wang, Jiayue Wang

et al.

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 227, P. 120794 - 120794

Published: March 9, 2025

Language: Английский

Citations

0
Andrographolide prevents necroptosis by suppressing the generation of reactive oxygen species DOI Creative Commons
Na Lu, Qing Li, Linghan Duan

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0