A Review of Molecular Investigations on Traditional Chinese Medicinal Plant-Based Therapies in Multidrug-Resistant Tuberculosis DOI Creative Commons

Robin Raj,

Arpan Kumar Tripathi,

P. B. Saranya

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 100521 - 100521

Published: Oct. 1, 2024

Language: Английский

Natural bioactive compounds form herbal medicine in Alzheimer’s disease: from the perspective of GSK-3β DOI Creative Commons
Mei Wang, Wendi Huang, Juan Huang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 7, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Glycogen synthase kinase 3β (GSK-3β) plays pivotal role in AD pathogenesis, particularly tau protein hyperphosphorylation. Natural bioactive compounds have wide range of sources, medicinally valuable active compound can be extracted from plants, animals, microorganisms. Currently, studies found that various natural plants the potential to improve symptoms, such as resveratrol berberine. Therefore, this review examines modulate GSK-3β activity inhibit hyperphosphorylation tau, offering promising therapeutic strategy for AD. We summarize current understanding alkaloids, phenols, flavonoids, terpenoids other compounds, highlighting their mechanisms action preclinical efficacy.

Language: Английский

Citations

1
Modified Shenqi Dihuang Decoction Inhibits Prostate Cancer Metastasis by Disrupting TCA Cycle Energy Metabolism via NF-kB/p65-mediated OGDH Regulation DOI
Tongtong Zhang,

Jixiang Yuan,

Xiran Ju

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156405 - 156405

Published: Jan. 20, 2025

Language: Английский

Citations

0
One Unified Model of Materials, Energies and Information on Traditional Chinese Medicine DOI
Jin-Hua Ouyang,

Xin Kong

European Journal of Medical and Health Research, Journal Year: 2025, Volume and Issue: 3(1), P. 119 - 126

Published: Jan. 1, 2025

Background: Traditional Chinese medicine (TCM) has unique theoretical systems and correspondingly characteristic therapies. However, the encounter many difficulties in propagation of TCM other countries. To dissolve these difficulties, researchers have found some ways from different viewpoints.Method: Based on research to one unified model materials, energies information (UMMEI) is presented.Discussions: In UMMEI TCM, healthy person a complex giant system which materials are fundamental, powerful, connecting. The with moving translating energies, controlling information. Jing, Blood, Jin, Ye, Zang organs, Fu Xingti, Guanqiao substantive materials. Qi insubstantial energy can be carriers whole body composed five six Guanqiao. mind life person. information, just like normal working mobile phone hardware, power supply, software. mechanisms representatives therapies curing large kind diseases based presented. Some discussions also given.

Language: Английский

Citations

0
Fine-Tuning Large Language Models for Syndrome Differentiation in Traditional Chinese Medicine DOI
Wenlong Song, Zixuan Li, Huaiyu Wang

et al.

Communications in computer and information science, Journal Year: 2025, Volume and Issue: unknown, P. 39 - 52

Published: Jan. 1, 2025

Language: Английский

Citations

0
Harnessing Plant Arsenal to Struggle with SARS-CoV-2: Approaches and Challenges DOI
Latifa Khattabi

Published: Jan. 1, 2025

Language: Английский

Citations

0
The neurobiology of plant-based therapeutics in women's reproductive health: mechanisms, efficacy, and clinical translation DOI Creative Commons
Xue Liu,

Chengli Bin,

Zihua Zhou

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 20, 2025

This review examines the neurobiological mechanisms by which plant-derived compounds influence women's reproductive health through neuroendocrine-reproductive axis. Gynecological disorders frequently present with neurological manifestations, including cognitive decline in perimenopause, anxiety and depression polycystic ovary syndrome (PCOS), central sensitization endometriosis. Bioactive from medicinal plants, polyphenols phytoestrogens, demonstrate therapeutic potential their anti-inflammatory, antioxidant, neuromodulatory properties. These multi-target offer advantages over conventional single-target therapies simultaneously regulating multiple physiological processes. The explores applications specific gynecological conditions discusses development of dietary supplements functional foods incorporating these ingredients. growing market for products presents opportunities innovative formulations enhanced bioavailability personalized approaches. Future research directions include integrating neuroimaging herbal research, improving clinical translation, establishing regulatory frameworks global application interventions to enhance female health.

Language: Английский

Citations

0
Natural bioactive compounds modified with mesenchymal stem cells: new hope for regenerative medicine DOI Creative Commons
Jingjing Wu, Ying Ge, Wendi Huang

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 9, 2025

Mesenchymal stem cells (MSCs) have the potential to differentiate into various cell types, providing important sources of for development regenerative medicine. Although MSCs advantages, there are also problems, such as low survival rate transplanted and poor migration homing; therefore, determining how reform improve their utilization is particularly important. many natural bioactive compounds shown great improving MSCs, mechanisms pathways involved; however, in final analysis, promoted MSC proliferation, homing differentiation antiaging. This article reviews regulatory effects on provide new ideas therapeutic modified diseases.

Language: Английский

Citations

0
The role of AMPKα subunit in Alzheimer's disease: In-depth analysis and future prospects DOI Creative Commons

Lingqiong Xia,

Jianhua Chen, Juan Huang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e34254 - e34254

Published: July 1, 2024

The AMP-activated protein kinase α (AMPKα) subunit is the catalytic in AMPK complex, playing a crucial role activation. It has two isoforms: AMPKα1 and AMPKα2. Emerging evidence suggests that AMPKα exhibits subtype-specific effects Alzheimer's disease (AD). This review discusses of pathogenesis AD, including its impact on β-amyloid (Aβ) pathology, Tau metabolic disorders, inflammation, mitochondrial dysfunction, inflammasome pyroptosis. Additionally, it reviews distinct roles isoforms, AMPKα2, which may provide more precise targets for future drug development AD.

Language: Английский

Citations

1
Traditional Chinese Medicine in Alzheimer's Disease: From the Perspective of GSK-3β and Tau Hyperphosphorylation DOI Creative Commons
Mei Wang, Wendi Huang, Juan Huang

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 13, P. 100543 - 100543

Published: Nov. 6, 2024

Language: Английский

Citations

1
A Review of Molecular Investigations on Traditional Chinese Medicinal Plant-Based Therapies in Multidrug-Resistant Tuberculosis DOI Creative Commons

Robin Raj,

Arpan Kumar Tripathi,

P. B. Saranya

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 100521 - 100521

Published: Oct. 1, 2024

Language: Английский

Citations

0