Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 5, 2025

Hepatocellular carcinoma (HCC) is one of the most prevalent cancers, characterized by high morbidity and mortality rates. Recently, immunotherapy has emerged as a crucial treatment modality for HCC, following surgery, locoregional therapies, targeted therapies. This approach harnesses body's immune system to target eliminate cancer cells, potentially resulting in durable antitumor responses. However, acquired resistance tumor immunosuppressive microenvironment (TIME) significantly hinder its clinical application. advancements nanotechnology, coupled with deeper understanding biology nano-biological interactions, have led development various nanoparticles aimed at enhancing therapeutic efficacy through specific targeting tissues. These increase accumulation immunotherapeutic drugs within microenvironment, thereby transforming TIME. In this review, we provide concise overview fundamental principles governing TIME landscape HCC discuss rationale applications context. Additionally, highlight existing challenges potential opportunities translation nanomedicines.

Language: Английский

LncRNA in gastric cancer drug resistance: deciphering the therapeutic strategies

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 1, 2025

Gastric cancer (GC) is an exceedingly aggressive disease and ranks as the third leading cause of cancer-related deaths, which poses a huge health burden globally. Chemotherapy commonly employed during middle to advanced stages cancer, although it faces frequent treatment failures attributed drug resistance. Thus, imperative for researchers identify potential targets overcoming therapeutic resistance, thereby facilitating development novel anti-cancer agents GC patients with stages. Long noncoding RNAs (lncRNAs) are diverse group transcripts limited protein-coding capacity, have been recognized functional molecules regulating progression including cell proliferation, metastasis, resistance in GC. In this review, we examine intricate molecular networks on role lncRNAs LncRNAs conferred through various mechanisms, therefore functioning promising patients. Additionally, discuss current advancements strategies targeting therapy, may pave way lncRNA-mediated precision medicine malignant disease.

Language: Английский

Exosome-based immunotherapy in hepatocellular carcinoma

Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 24, 2025

Language: Английский