Mesenchymal stem cell-derived exosomes: an emerging therapeutic strategy for hepatic ischemia-reperfusion injury

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 14, 2025

Hepatic ischemia-reperfusion injury (HIRI) severely threatens the success rates of liver surgery and transplantation. Its complex pathological process involves multiple factors such as oxidative stress, inflammatory responses, ferroptosis, creating an urgent need for new therapeutic strategies. Exosomes derived from mesenchymal stem cells (MSCs) are emerging a next-generation acellular approach. With their outstanding immune-regulatory capabilities, significant reparative functions, good biocompatibility, they leading innovations in field HIRI treatment. This article provides systematic comparison characteristics MSC-derived exosomes(MSC-EXOs) four different sources: adipose tissue, bone marrow, umbilical cord, induced pluripotent cells. Although clinical translation MSC-EXOs still faces challenges variations isolation methods, large-scale production, safety assessments, remarkable effects vast application potential signal arrival era precision treatment HIRI. review not only comprehensive theoretical foundation to promote but also opens up innovative research directions regenerative medicine.

Language: Английский

Mesenchymal Stem Cells: What We Have Learned and How to Manage Them

Biology, Journal Year: 2024, Volume and Issue: 14(1), P. 1 - 1

Published: Dec. 24, 2024

Regenerative medicine is the new frontier of [...].

Language: Английский