The Synergistic Mechanism of Chelidonium majus Alkaloids on Melanoma Treatment via a Multi-Strategy Insight DOI Creative Commons
Peng Chen,

Xin-ye Ji,

Jianghe Feng

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5412 - 5412

Published: Nov. 16, 2024

Melanoma represents a formidable challenge in dermatological oncology due to its resistance conventional treatments. The Celandine Alkali Injection Formula (CAIF) offers benefits on clinical internal medicine treatments, within which chelidonine and tetrandrine are recognized as potential quality markers. However, their synergistic mechanisms facilitating anti-melanoma action remain unveiled. This study embarked an exploration of CAIF's therapeutic through multifaceted research design, integrating system pharmacological predictions with empirical molecular biological evaluations. dual application CAIF exhibited pronounced inhibitory effect the proliferation B16F10 cells, surpassing effectiveness individual compound administration. Computational identified top 50 targets, involved key signaling pathways including cell cycle regulation, melanogenesis. RNA sequencing further elucidated that combinatory treatment modulated broader spectrum differentially expressed genes, implicating crucial processes differentiation, tyrosinase metabolism. combination markedly enhanced melanogenesis apoptotic indices, arrested progression, fostered cellular differentiation. Notably, additionally curtailed migratory capacity cells. Our findings underscore tetrandrine, components CAIF, effectively combating melanoma by targeting proliferation, migration,

Language: Английский

Hylomecon japonica: A Review About Botanical Aspects, Traditional Applications, Chemical Composition, and Pharmacological Properties DOI Creative Commons
Yue Tian, Guangqing Xia,

Junyi Zhu

et al.

Horticulturae, Journal Year: 2025, Volume and Issue: 11(1), P. 60 - 60

Published: Jan. 8, 2025

Hylomecon japonica (Thunb.) Prantl et Kundig is a plant whose root and rhizome belong to the genus within Papaveraceae family. It has long medicinal history been traditionally used treat various conditions, including wind–cold–dampness obstruction syndrome, rheumatic joint pain, traumatic injuries, excessive fatigue, weakness of limbs, epigastric dysentery. Modern pharmacological research confirms that exhibits effects such as anticancer, anti-inflammatory, antibacterial activities. To gain comprehensive understanding this plant, thorough literature review was conducted using databases like Scifinder, Web Science, PubMed, Scopus, CNKI. This provides an overview traditional applications, geographical distribution, botanical description, chemical composition, japonica. Researchers have isolated identified total one hundred thirty-five components from japonica, alkaloids, saponins, phenolics, flavonoids, other compounds, trace elements. Notably, alkaloids saponins shown significant anti-tumor effects. Additionally, extracts demonstrated promising activity in anti-obesity, varicose vein treatment applications. Despite existing foundational research, further studies are necessary enhance our its mechanisms pathways action. will provide valuable references for active ingredient development utilization japonica’s value. By continuing explore plant’s potential, we can pave way new therapeutic advancements improve health outcomes patients worldwide.

Language: Английский

Citations

0
Nematicidal potential of berberine and sanguinarine from Chelidonium majus against Meloidogyne incognita DOI
Fung‐Jou Lu, Zixuan Wang,

Young Jin Chang

et al.

Journal of Asia-Pacific Entomology, Journal Year: 2025, Volume and Issue: unknown, P. 102384 - 102384

Published: Feb. 1, 2025

Language: Английский

Citations

0
Comprehensive Approach to Liver Cirrhosis Treatment: Integrating Ayurveda, Homeopathy, and Allopathy DOI
Debabrata Dash,

Palak Kesharwani,

Raj Kumar Koiri

et al.

Pharmacological Research - Natural Products, Journal Year: 2025, Volume and Issue: unknown, P. 100184 - 100184

Published: Feb. 1, 2025

Language: Английский

Citations

0
Mineral Composition of Chelidonium majus L. and Soils in Urban Areas DOI Creative Commons
Oimahmad Rahmonov, Dorota Środek, Sławomir Pytel

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(9), P. 4718 - 4718

Published: April 24, 2025

Chelidonium majus L. is a species with wide medicinal use, commonly found in anthropogenically degraded habitats, forest edges, and urban parks. This study aimed to determine the chemical composition of leaves, stems, roots Ch. soil its rhizosphere terms content main elements (Fe, Ca, P, Mg, Al, Na, K, S), trace rare earth minerals (Ti, Mo, Ag, U, Au, Th, Sb, Bi, V, La, B, W, Sc, Tl, Se, Te, Ga, Cs, Ge, Hf, Nb, Rb, Sn, Ta, Zr, Y, Ce, In, Be, Li), their comparison parts analyzed. The was conducted five parks southern Poland historically industrialized area. results showed that Ca has highest among macroelements. Its leaf ranges from 24,700 40,700 mg·kg−1, while soil, it 6500 15,000 mg·kg−1. In low values Al (100–500 mg·kg−1) Na (100 were other tested, high (5100–9800 soils. Among macroelements K concentration (>100,000 mg·kg−1), 3–4 times lower stems than leaves. Rhizomes accumulate most range 22,800–29,900 mg·kg−1 5400–8900 respectively. Fe all locations have higher tissues. turn, S plants soil. Determining elemental important information, as plant draws these and, at levels toxicity, may indicate should not be taken this habitat for purposes.

Language: Английский

Citations

0
The Synergistic Mechanism of Chelidonium majus Alkaloids on Melanoma Treatment via a Multi-Strategy Insight DOI Creative Commons
Peng Chen,

Xin-ye Ji,

Jianghe Feng

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5412 - 5412

Published: Nov. 16, 2024

Melanoma represents a formidable challenge in dermatological oncology due to its resistance conventional treatments. The Celandine Alkali Injection Formula (CAIF) offers benefits on clinical internal medicine treatments, within which chelidonine and tetrandrine are recognized as potential quality markers. However, their synergistic mechanisms facilitating anti-melanoma action remain unveiled. This study embarked an exploration of CAIF's therapeutic through multifaceted research design, integrating system pharmacological predictions with empirical molecular biological evaluations. dual application CAIF exhibited pronounced inhibitory effect the proliferation B16F10 cells, surpassing effectiveness individual compound administration. Computational identified top 50 targets, involved key signaling pathways including cell cycle regulation, melanogenesis. RNA sequencing further elucidated that combinatory treatment modulated broader spectrum differentially expressed genes, implicating crucial processes differentiation, tyrosinase metabolism. combination markedly enhanced melanogenesis apoptotic indices, arrested progression, fostered cellular differentiation. Notably, additionally curtailed migratory capacity cells. Our findings underscore tetrandrine, components CAIF, effectively combating melanoma by targeting proliferation, migration,

Language: Английский

Citations

0