Rising of natural therapies: Potential and challenges of traditional Chinese medicine in the management of gastrointestinal diseases

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(9)

Published: Feb. 18, 2025

In the contemporary medical landscape, burgeoning interest in natural therapies, particularly for managing gastrointestinal disorders, has brought traditional Chinese medicine (TCM) to forefront. This article explains core principles and clinical applications of TCM treating these conditions, furthering discourse through an examination integrated strategies, as demonstrated study by Zhou et al. While shown promising outcomes, it encounters significant hurdles standardization, mechanistic research, validation. Future investigations should aim solidify scientific underpinnings expand its use disease management, striving a seamless fusion practices.

Language: Английский

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Chinese herbal medicine improves antioxidant capacity of chicken liver at high stocking density involved gut-liver microbiota axis based on multi-omics technologies

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105015 - 105015

Published: March 1, 2025

Traditional Chinese Medicine (TCM), such as artemisinin, berberine and proanthocyanidin, has been considered an effective additive for broiler production. High density farming (HDF), which is the primary modern mode of chicken production, associated with animal health problems. This work aimed to evaluate effects dietary TCMs (dihydroartemisinin, hydrochloride, oligomeric proanthocyanidins) on improving antioxidant capacity chickens under HDF their underlying mechanisms. A total 360 Wuding (134-day-old) were divided into five experimental groups: one normal stocking (8 birds/m2, control group) four high (16 birds/m2), six replicates each group. For groups, group was fed basal diet, other three groups diet supplemented 80 mg/kg dihydroartemisinin, 600 250 grape proanthocyanidins, respectively. increased malondialadehyde level, but decreased superoxide dismutase, glutathione peroxidase levels in liver broiler; however, apparently alleviated this attenuation. Dietary significantly expression genes involved cholesterol synthesis tripepides intestine chickens. Meanwhile, altered composition microbiome chickens, expressing by reduced Pseudomonas enriched Bradyrhizobium. The gut microbiota also following TCM administration, a abundance Microbacter margulisiae acetate genes. Association analysis multi-omics results revealed negative correlations between factors that could be regulated microbiota-produced short-chain fatty acids. Furthermore, alleviating oxidative stress showed significant microbiome, mediated tripeptides produced microbiota. These indicated beneficial defenses interpreted mechanisms action from perspective science.

Language: Английский

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Gut-Brain Axis-Based Polygala Tenuifolia and Magnolia Officinalis Improve D-gal-Induced Cognitive Impairment in Mice Through cAMP and NF-κB Signaling Pathways

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 1869 - 1894

Published: March 1, 2025

Polygala tenuifolia Willd. (PT) is commonly used to address cognitive impairment (CI), while Magnolia officinalis Rehd. et Wils (MO) often prescribed for gastrointestinal issues as well CI. This study seeks explore the impacts and mechanisms behind combined therapy of PT MO (PM) in treating CI, based on concept gut-brain axis. The characteristic components PT, MO, PM were identified using ultra-high performance liquid chromatography-tandem triple quadrupole mass Spectrometry (UPLC-MS/MS). A mouse model was established by D-gal induction, effects CI evaluated through behavioral tests, pathological staining, Enzyme-Linked Immunosorbent Assay (ELISA). Subsequently, network pharmacology analyze potential which improves followed validation Western blotting (WB), traditional Chinese medicine (TEM), Immunofluorescence (IF), 16S rRNA. can each alleviate decline neuropathological damage mice varying degrees, reduce expression pro-inflammatory factors (TNF-α, IL-1β, IL-6, IFN-γ, LPS) serum or hippocampal tissue, increase SOD GSH levels. Network analysis molecular experiments confirmed that upregulates tight junction s (TJs), enhances proteins cAMP pathway, inhibits p-NF-κB-p65 expression. reverses D-gal-induced gut microbiota dysbiosis, increases abundance SCFA-producing bacteria, decreases LPS-producing bacteria. alleviates reducing inflammation oxidative stress, protecting blood-brain barrier (BBB) intestinal barrier, inhibiting NF-κB activating regulating microbiota.

Language: Английский

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Angelicae Pubescentis Radix Remitted Intestine Damage in Mice Induced by Escherichia coli via Mediating Antioxidant Defense, Inflammatory Mediators, and Restoring Gut Microbiota

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(4), P. 354 - 354

Published: April 10, 2025

This study aims to explore the therapeutic potential of Angelicae Pubescentis Radix (APR), a traditional Chinese medicine that is widely known for its anti-inflammatory, anti-oxidative, and anti-microbial properties, using mouse model. In this study, 30 mice were selected divided into three groups: control group (CD), infection (ED), treatment (TD). Mice in TD gavaged with APR oil (0.15 mL/kg/day) 20 days, while CD ED received an equal volume normal saline. On 21st day, infected multi-drug-resistant E. coli (1 × 107 CFU/mL) derived from diarrheal yak. Twenty-four hours later, all euthanized, blood, organs, intestinal samples collected analysis. The results sections bacterial load revealed significantly reduced (p < 0.05) both injury. Serum analysis indicated also alleviated inflammation oxidative stress induced by infection. Intestinal microbiota sequencing further showed increased abundance probiotics such as Ligilactobacillus, Paludicola, Blautia_A_1417806 enhancing enrichment functional pathways associated antioxidant defense. conclusion, effectively alleviates diseases caused infection, promotes growth beneficial bacteria, improves capacity animals. Additionally, these findings confirm APR’s role addressing immediate effects rather than chronic adaptations. Future studies should investigate prolonged beyond acute phase.

Language: Английский

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