Wogonoside alleviates the proliferation and promotes the apoptosis in liver cancer cells by regulating PI3K/Akt signaling pathway

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 26, 2025

Primary liver cancer is associated with high morbidity and mortality rate. In about 50% of cases, primary related to the phosphoinositide-3-kinase (PI3K)/Akt signaling pathway. Wogonoside an active component extracted from Scutellaria baicalensis. Its antitumor effects in are scarcely known. This study explores correlation between wogonoside PI3K/Akt pathway vitro. THLE-2 cells HepG2 were treated different concentrations establish low-, medium- high- dose groups, concentration each group was determined by CCK-8 assay. Subsequent experiments evaluated viability, proliferation, invasion, wound healing, apoptosis rate cells, as well expression levels relevant targets. silico network pharmacology performed investigate relationship pathway, providing insights into connection cancer. Compared control group, migration healing ability wogonoside-treated significantly declined a dose- time-dependent manner. reduced relative level Bcl-2/Bax protein. also decreased protein phospho-PI3K/PI3K phospho-AKT/AKT mRNA PI3K AKT. addition, potential key genes, biological processes, pathways therapeutic on explored. can alleviate proliferation promote which may be

Language: Английский

Unraveling the Role of Cathepsin B Variants in Polycystic Ovary Syndrome: Insights from a Case-Control Study and Computational Analyses

Reproductive Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

Targeting ferroptosis for the treatment of female reproductive system disorders

Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский