Natural products in traditional Chinese medicine for renal fibrosis: a comprehensive review

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Renal fibrosis represents the terminal pathological manifestation of most chronic kidney diseases, driving progressive loss renal function. Natural products have emerged as promising therapeutic agents for preventing and ameliorating due to their multi-target efficacy favorable safety profiles. In this review, we conducted a comprehensive literature search on PubMed using keywords "natural product" "renal fibrosis" from 2004 2025, identifying 704 relevant articles. We systematically categorize discuss biological effects key natural formulations with antifibrotic potential, focusing five major classes: glycosides, flavonoids, phenolic compounds, anthraquinones, terpenoids. Representative compounds each category are highlighted mechanisms action, including modulation oxidative stress, inflammation, autophagy, signaling pathways. This review aims provide theoretical foundation development product-based therapies combat fibrosis, offering insights into potential future research directions.

Language: Английский

Perturbed gut microbiota and serum metabolites are associated with progressive renal fibrosis

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 28, 2025

Introduction The intricate pathogenesis of renal fibrosis necessitates identifying biomarkers at various stages to facilitate targeted therapeutic interventions, which would enhance patient survival rates and significantly improve prognosis. Methods We investigated the changes in gut microbiota serum metabolites during early, middle, late rats using 16S rDNA sequencing UPLC-QTOF/MS-based metabolomics. Results identified 5, 21, 14 potential microbial markers 19, 23, 31 metabolic MOD1, MOD2, MOD4 groups, respectively. Bifidobacterium was as a shared marker between MOD1 MOD2 groups; Prevotellaceae_NK3B31_group Bacteroides were groups. pathways arachidonic acid metabolism retinol found play significant role modulation 1, 2, 4 weeks. Notably, 8,9-EET 5(S)-HPETE within these emerged critical determinants influencing fibrosis. Discussion Our findings demonstrated that severity is associated with dysbiosis alterations metabolites.

Language: Английский

Levosimendan mitigates renal fibrosis via TGF-β1/Smad axis modulation in UUO rats

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118124 - 118124

Published: May 3, 2025

Language: Английский