The potential of novel arsenic nanoparticles containing metformin (MTF@As NPs): a study on their antioxidant and cytotoxic properties DOI Creative Commons
Mohammad Reza Shakibaie, Seyed Soheil Hosseininasab,

Soudabe Riahi-Madvar

et al.

BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)

Published: March 28, 2025

In the present research, arsenic nanoparticles containing metformin (MTF@As NPs) were synthesized by subjecting a mixture of As2O3 and sodium borohydride solution to microwave irradiation in presence metformin. The physicochemical properties prepared analyzed using UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), energy-dispersive X-ray (EDS), scanning electron microscopy (SEM). assessed for their antioxidant potential, hemocompatibility, cytotoxic effects. Based on study's findings, it was found that MTF@As NPs have size range 14–38 nm. DPPH scavenging iron-reducing assays demonstrated exhibited significantly higher activity than As (80–1280 µg/mL). study also revealed compatible materials did not induce significant hemolysis RBCs. According study, concentration required death half cells (IC50) treated with after 24 h be 33.5 ± 2.6 µg/mL 5.7 0.3 MCF-7, NIH3T3 cells, respectively. Notably, toxicity against MCF-7 at concentrations (40–1280 This provides insights into NPs, additional investigation is necessary fully understand these nanoparticles' underlying biological mechanisms.

Language: Английский

Exploring the anti-anaphylaxis potential of natural products: A Review DOI Creative Commons
Ahmed Salem Eid,

Eman M. Zaki,

Manal M. Sabry

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abstract Allergies are a common health issue affecting many people around the world, especially in developed countries. They occur when immune system overreacts to substances that usually harmless. Some allergic conditions include asthma, sinus infections, skin rashes, food allergies, hay fever, severe reactions, eczema, swelling, and reactions medications or insect stings. The causes of these allergies complex often linked genetics, which can lead heightened responses known as atopy. Throughout history, plant extracts have been used for various purposes, including medicine food. In addition, their bioactive compounds show wide range beneficial effects, such reducing fighting oxidative stress, mast cell stabilizers, lowering inflammation, highlighting potential treating conditions. Flavonoids phenolic commonly anaphylaxis potent anti-inflammatory action. This review aims promote use natural products treatments anaphylaxis. discovery new drugs derived from sources holds significant promise management

Language: Английский

Citations

0
The potential of novel arsenic nanoparticles containing metformin (MTF@As NPs): a study on their antioxidant and cytotoxic properties DOI Creative Commons
Mohammad Reza Shakibaie, Seyed Soheil Hosseininasab,

Soudabe Riahi-Madvar

et al.

BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)

Published: March 28, 2025

In the present research, arsenic nanoparticles containing metformin (MTF@As NPs) were synthesized by subjecting a mixture of As2O3 and sodium borohydride solution to microwave irradiation in presence metformin. The physicochemical properties prepared analyzed using UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), energy-dispersive X-ray (EDS), scanning electron microscopy (SEM). assessed for their antioxidant potential, hemocompatibility, cytotoxic effects. Based on study's findings, it was found that MTF@As NPs have size range 14–38 nm. DPPH scavenging iron-reducing assays demonstrated exhibited significantly higher activity than As (80–1280 µg/mL). study also revealed compatible materials did not induce significant hemolysis RBCs. According study, concentration required death half cells (IC50) treated with after 24 h be 33.5 ± 2.6 µg/mL 5.7 0.3 MCF-7, NIH3T3 cells, respectively. Notably, toxicity against MCF-7 at concentrations (40–1280 This provides insights into NPs, additional investigation is necessary fully understand these nanoparticles' underlying biological mechanisms.

Language: Английский

Citations

0