Influence of N-Acetyl-L-Cysteine on the Pharmacokinetics and Antibacterial Activity of Marbofloxacin in Chickens DOI Creative Commons
Albena Roydeva,

Nikolina Rusenova,

Aneliya Milanova

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(4), P. 393 - 393

Published: April 10, 2025

Background/Objectives: Marbofloxacin, a second-generation fluoroquinolone, is used to control economically significant poultry diseases caused by pathogenic bacteria such as Staphylococcus aureus and Escherichia coli. Although synergistic antimicrobial activity between fluoroquinolones N-acetyl-L-cysteine (NAC) has been observed in vitro, data on their pharmacokinetic interactions vivo remain limited. This study aimed evaluate the effect of NAC oral pharmacokinetics marbofloxacin broiler chickens its antibacterial against E. coli ATCC 25922 S. 25923, assessing potential benefits combined administration. Methods: The was evaluated broilers (5 mg/kg dose) after single intravenous (n = 12) or administration into crop. protocol for co-administration (400 via feed) follows: first day, received dose crop over next four days fluoroquinolone drug administered drinking water. plasma levels drugs were determined using LC-MS/MS analyses, minimum inhibitory concentrations microbroth dilution method. Results: significantly reduced bioavailability decreased elimination rate constant following both drugs. At concentration 20 μg/mL, led 3.8-fold reduction MIC 2-fold decrease at 1 μg/mL 6 while no change marbofloxacin’s 25923. Conclusions: Oral fluoroquinolone’s two-fold enhancing 25922.

Language: Английский

Influence of N-Acetyl-L-Cysteine on the Pharmacokinetics and Antibacterial Activity of Marbofloxacin in Chickens DOI Creative Commons
Albena Roydeva,

Nikolina Rusenova,

Aneliya Milanova

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(4), P. 393 - 393

Published: April 10, 2025

Background/Objectives: Marbofloxacin, a second-generation fluoroquinolone, is used to control economically significant poultry diseases caused by pathogenic bacteria such as Staphylococcus aureus and Escherichia coli. Although synergistic antimicrobial activity between fluoroquinolones N-acetyl-L-cysteine (NAC) has been observed in vitro, data on their pharmacokinetic interactions vivo remain limited. This study aimed evaluate the effect of NAC oral pharmacokinetics marbofloxacin broiler chickens its antibacterial against E. coli ATCC 25922 S. 25923, assessing potential benefits combined administration. Methods: The was evaluated broilers (5 mg/kg dose) after single intravenous (n = 12) or administration into crop. protocol for co-administration (400 via feed) follows: first day, received dose crop over next four days fluoroquinolone drug administered drinking water. plasma levels drugs were determined using LC-MS/MS analyses, minimum inhibitory concentrations microbroth dilution method. Results: significantly reduced bioavailability decreased elimination rate constant following both drugs. At concentration 20 μg/mL, led 3.8-fold reduction MIC 2-fold decrease at 1 μg/mL 6 while no change marbofloxacin’s 25923. Conclusions: Oral fluoroquinolone’s two-fold enhancing 25922.

Language: Английский

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