Unraveling the Role of Repurposed Drugs in the Treatment of Acne: Success so Far and the Road Ahead DOI Creative Commons
Popat Kumbhar,

Vikas Kamble,

Kaustubh Kolekar

et al.

Drug Development Research, Journal Year: 2025, Volume and Issue: 86(1)

Published: Feb. 1, 2025

Acne is a skin disease that impacts 9.4% of the world's population. Available treatments for managing acne include retinoid-like drugs, antibiotics, corticosteroids, photo, and radiotherapy. Howevere, aforementioned have certain limitations such as possibility developing cancer from tetracycline, doxycycline, microbial resistance to deadly side effects, so forth. Repurposing existing therapeutics having excellent safety profile can be promising way treat efficiently. The repurposed drugs phytoceuticals diverse classes demonstrated effects in treating acne. These displayed antiacne effectiveness by targeting single or multiple signaling pathways. Various undergoing clinical trials at different phases their efficacy Despite being very good, safe, less time-consuming strategy, drug repurposing (DR) faces challenges lack regulatory guidelines, preservation intellectual property, validation claimed therapeutic indication. DR appears viable approach likely offer effective treatment reasonable cost alleviating

Language: Английский

Unraveling the Role of Repurposed Drugs in the Treatment of Acne: Success so Far and the Road Ahead DOI Creative Commons
Popat Kumbhar,

Vikas Kamble,

Kaustubh Kolekar

et al.

Drug Development Research, Journal Year: 2025, Volume and Issue: 86(1)

Published: Feb. 1, 2025

Acne is a skin disease that impacts 9.4% of the world's population. Available treatments for managing acne include retinoid-like drugs, antibiotics, corticosteroids, photo, and radiotherapy. Howevere, aforementioned have certain limitations such as possibility developing cancer from tetracycline, doxycycline, microbial resistance to deadly side effects, so forth. Repurposing existing therapeutics having excellent safety profile can be promising way treat efficiently. The repurposed drugs phytoceuticals diverse classes demonstrated effects in treating acne. These displayed antiacne effectiveness by targeting single or multiple signaling pathways. Various undergoing clinical trials at different phases their efficacy Despite being very good, safe, less time-consuming strategy, drug repurposing (DR) faces challenges lack regulatory guidelines, preservation intellectual property, validation claimed therapeutic indication. DR appears viable approach likely offer effective treatment reasonable cost alleviating

Language: Английский

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