Exploring the application of metal-based photothermal agents in photothermal therapy combined with immune checkpoint therapy

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 13, 2025

Photothermal therapy (PTT), a popular local treatment that uses heat to ablate tumors, has limited efficacy in addressing metastatic and deeply located tumors when used alone. Integrating PTT with immunotherapy not only yields synergistic effect but also promotes cancer regression confers the benefit of immune memory, which can surmount challenges faced by isolation. Metal-based nanomaterials, renowned for their superior photothermal conversion efficiency distinctive photochemical properties, have been extensively researched applied field PTT. This review summarizes latest developments combination therapies, specific focus on checkpoint (ICT) treatment, including comprehensive overview recent advancements noble metal-based 2D transition metal chalcogenides (TMDCs)-based agents, anticancer combining blockades (anti-CTLA-4 anti-PD-L1) therapy. The goal this is present an application, current future prospects agents combined ICT treatment.

Language: Английский

Engineered hybrid cell membrane nanovesicles for potentiated cancer immunotherapy through dual immune checkpoint inhibition

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In this study, we developed a PD-1/LAG-3 receptors-decorated cell membrane nanovesicle for combination immunotherapy in colorectal cancer. The hybrid substantially inhibited tumor growth and elicited robust antitumor immune response MC38 xenograft-bearing mice.

Language: Английский