Anti‐Inflammatory Compounds From Roots of Heracleum sphondylium subsp. cyclocarpum DOI Creative Commons
Ekin Kurtul, Özlem Bahadır Açıkara,

Büşra Karpuz Ağören

et al.

Chemical Biology & Drug Design, Journal Year: 2025, Volume and Issue: 105(2)

Published: Feb. 1, 2025

ABSTRACT Heracleum sphondylium subsp. cyclocarpum (K. Koch) P.H. Davis from L. genus, which is one of the widest genera Apiaceae family and known as “Hogweed or Tavşancılotu”. This genus has a variety traditional uses, including treating gastrointestinal, cardiovascular, gynecological, cognitive disorders, skin problems, rheumatism, inflammation. In particular, these plants are commonly used for inflammatory diseases. research aimed to examine in detail anti‐inflammatory properties roots. Bioactivity‐guided fractionation was isolate active compounds. Carrageenan‐ prostaglandin E2‐induced inflammation models were employed test activity. Dichloromethane methanolic extracts plant material tested activity found be effective inhibiting The subfractions obtained by column chromatography further evaluated their activities. fractions obtain responsible compounds using semipreparative HPLC. Five coumarin derivatives isolated identified heraclenol (1), byakangelicin (2), heraclenol‐3″‐ O ‐ β ‐glucoside (3), byakangelicin‐3″‐ (4), meranzin hydrate III (5). investigated activities, O‐β inhibit carrageenan edema significantly compared control group have higher than extracts.

Language: Английский

Anti‐Inflammatory Compounds From Roots of Heracleum sphondylium subsp. cyclocarpum DOI Creative Commons
Ekin Kurtul, Özlem Bahadır Açıkara,

Büşra Karpuz Ağören

et al.

Chemical Biology & Drug Design, Journal Year: 2025, Volume and Issue: 105(2)

Published: Feb. 1, 2025

ABSTRACT Heracleum sphondylium subsp. cyclocarpum (K. Koch) P.H. Davis from L. genus, which is one of the widest genera Apiaceae family and known as “Hogweed or Tavşancılotu”. This genus has a variety traditional uses, including treating gastrointestinal, cardiovascular, gynecological, cognitive disorders, skin problems, rheumatism, inflammation. In particular, these plants are commonly used for inflammatory diseases. research aimed to examine in detail anti‐inflammatory properties roots. Bioactivity‐guided fractionation was isolate active compounds. Carrageenan‐ prostaglandin E2‐induced inflammation models were employed test activity. Dichloromethane methanolic extracts plant material tested activity found be effective inhibiting The subfractions obtained by column chromatography further evaluated their activities. fractions obtain responsible compounds using semipreparative HPLC. Five coumarin derivatives isolated identified heraclenol (1), byakangelicin (2), heraclenol‐3″‐ O ‐ β ‐glucoside (3), byakangelicin‐3″‐ (4), meranzin hydrate III (5). investigated activities, O‐β inhibit carrageenan edema significantly compared control group have higher than extracts.

Language: Английский

Citations

0