Molecular Insights into Oxidative-Stress-Mediated Cardiomyopathy and Potential Therapeutic Strategies DOI Creative Commons
Zhengfeng Xiong, Yuanpeng Liao, Z. Zhang

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 670 - 670

Published: May 6, 2025

Cardiomyopathies comprise a heterogeneous group of cardiac disorders characterized by structural and functional abnormalities in the absence significant coronary artery disease, hypertension, valvular or congenital defects. Major subtypes include hypertrophic, dilated, arrhythmogenic, stress-induced cardiomyopathies. Oxidative stress (OS), resulting from an imbalance between reactive oxygen species (ROS) production antioxidant defenses, has emerged as key contributor to pathogenesis these conditions. ROS-mediated injury drives inflammation, protease activation, mitochondrial dysfunction, cardiomyocyte damage, thereby promoting remodeling decline. Although numerous studies implicate OS cardiomyopathy progression, precise molecular mechanisms remain incompletely defined. This review provides updated synthesis current findings on OS-related signaling pathways across subtypes, emphasizing emerging therapeutic targets within redox-regulatory networks. A deeper understanding may guide development targeted strategies improve clinical outcomes affected patients.

Language: Английский

Association fasting blood sugar to high-density lipoprotein cholesterol ratio and hypertension: Analysis from the National Health and Nutrition Examination Survey (2003– 2018) DOI

Suyi Luo,

Jianqing Zhu,

Le Yang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract Hypertension is a chronic disease that poses significant threat to human health worldwide. The ratio of fasting blood sugar high-density lipoprotein cholesterol (GHR) an emerging biomarker associated with various diseases. However, the relationship between GHR and hypertension was still unclear. This study aimed explore correlation high pressure. conducted comprehensive cross-sectional analysis based on data from National Health Nutrition Examination Survey (NHANES) 2003 2018. used multivariate logistic regression model evaluate hypertension. It also verified robustness results through subgroup analysis. In addition, restricted cubic splines (RCS) analyze possible nonlinear hypertension, as well potential threshold effects. Finally, evaluated predictive efficiency for receiver operating characteristic (ROC) curve showed that, without adjusting confounding factors, positively correlated (OR = 1.20, 95%CI 1.17–1.22, P < 0.001). After fully factors (including gender, race, age, body mass index, smoking status, alcohol consumption, diabetes, stroke, total cholesterol, creatinine), positive existed 1.06, 1.03–1.09, Subgroup further association remained consistent across different subgroups. ROC revealed turning point 2.36. Furthermore, indicated demonstrated in univariate multivariate-adjusted models. A had serve biological marker facilitating its prevention diagnosis.

Language: Английский

Citations

0
Molecular Insights into Oxidative-Stress-Mediated Cardiomyopathy and Potential Therapeutic Strategies DOI Creative Commons
Zhengfeng Xiong, Yuanpeng Liao, Z. Zhang

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 670 - 670

Published: May 6, 2025

Cardiomyopathies comprise a heterogeneous group of cardiac disorders characterized by structural and functional abnormalities in the absence significant coronary artery disease, hypertension, valvular or congenital defects. Major subtypes include hypertrophic, dilated, arrhythmogenic, stress-induced cardiomyopathies. Oxidative stress (OS), resulting from an imbalance between reactive oxygen species (ROS) production antioxidant defenses, has emerged as key contributor to pathogenesis these conditions. ROS-mediated injury drives inflammation, protease activation, mitochondrial dysfunction, cardiomyocyte damage, thereby promoting remodeling decline. Although numerous studies implicate OS cardiomyopathy progression, precise molecular mechanisms remain incompletely defined. This review provides updated synthesis current findings on OS-related signaling pathways across subtypes, emphasizing emerging therapeutic targets within redox-regulatory networks. A deeper understanding may guide development targeted strategies improve clinical outcomes affected patients.

Language: Английский

Citations

0