Association between exposure to per- and polyfluoroalkyl substances and kidney function: a population study DOI Creative Commons
Xue Zhang, Yongping Cao,

Xiaona Yang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 26, 2025

Background The relationship between per- and polyfluoroalkyl substances (PFAS) kidney function markers remains uncertain. Methods We used PFAS detection data from 5,947 adults in NHANES 2005–2012. employed multivariable linear regression models to examine associations estimated glomerular filtration rate (eGFR), urine creatinine (UCR), albumin (UAL), albumin/creatinine ratio (UACR). To capture non-linear trends, restricted cubic splines were applied. WQS (weighted quantile sum) Q-gcomp (quantile g computation) for the mixture analysis. Subgroup analyses conducted explore potential interactions. Results Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic (PFOS), perfluorohexane (PFHxS), 2-(N-methyl-perfluorooctane sulfonamido) acetic (N-MEFOSAA), perfluorononanoic (PFNA) negatively related eGFR ( β = −2.04, 95% CI −2.85, −1.23; −0.97, −1.78, −0.16; −1.50, −2.24, −0.76; −0.49, −1.25, 0.27; −0.68, −1.46, 0.10). PFOA PFOS positive associated with UCR 10.61, −1.89, 23.11; 12.98, 0.56, 25.41). PFOA, PFOS, PFHxS, PFNA, PFUA UAL −0.53, −0.73, −0.32; −0.39, −0.59, −0.18; −0.78, −0.40; −0.42, −0.65, −0.19; −0.04, −0.22, 0.14). PFDA, PFNA are significantly inversely UACR −0.01, −0.16, 0.14; −0.52, −0.69, −0.35; −0.50, −0.67, −0.33; −0.64, −0.27, −0.44, −0.10). Nonlinear relationships found all indicators. Mixed exposure showed a negative association eGFR, UACR, while UCR. Interactions PFASs most subgroups observed. Conclusion Our study revealed significant various These findings provide an epidemiological perspective on how may lead dysfunction.

Language: Английский

Puerarin Modulates the P62-Keap1-NRF2 Pathway and Enhances CA7 Function to Inhibit Ferroptosis in Ethanol-Induced Gastric Mucosal Injury DOI

Xin-Ran Liu,

Jiayi Ge,

Ximing J. Yang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106127 - 106127

Published: Feb. 1, 2025

Language: Английский

Citations

0
Association between exposure to per- and polyfluoroalkyl substances and kidney function: a population study DOI Creative Commons
Xue Zhang, Yongping Cao,

Xiaona Yang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 26, 2025

Background The relationship between per- and polyfluoroalkyl substances (PFAS) kidney function markers remains uncertain. Methods We used PFAS detection data from 5,947 adults in NHANES 2005–2012. employed multivariable linear regression models to examine associations estimated glomerular filtration rate (eGFR), urine creatinine (UCR), albumin (UAL), albumin/creatinine ratio (UACR). To capture non-linear trends, restricted cubic splines were applied. WQS (weighted quantile sum) Q-gcomp (quantile g computation) for the mixture analysis. Subgroup analyses conducted explore potential interactions. Results Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic (PFOS), perfluorohexane (PFHxS), 2-(N-methyl-perfluorooctane sulfonamido) acetic (N-MEFOSAA), perfluorononanoic (PFNA) negatively related eGFR ( β = −2.04, 95% CI −2.85, −1.23; −0.97, −1.78, −0.16; −1.50, −2.24, −0.76; −0.49, −1.25, 0.27; −0.68, −1.46, 0.10). PFOA PFOS positive associated with UCR 10.61, −1.89, 23.11; 12.98, 0.56, 25.41). PFOA, PFOS, PFHxS, PFNA, PFUA UAL −0.53, −0.73, −0.32; −0.39, −0.59, −0.18; −0.78, −0.40; −0.42, −0.65, −0.19; −0.04, −0.22, 0.14). PFDA, PFNA are significantly inversely UACR −0.01, −0.16, 0.14; −0.52, −0.69, −0.35; −0.50, −0.67, −0.33; −0.64, −0.27, −0.44, −0.10). Nonlinear relationships found all indicators. Mixed exposure showed a negative association eGFR, UACR, while UCR. Interactions PFASs most subgroups observed. Conclusion Our study revealed significant various These findings provide an epidemiological perspective on how may lead dysfunction.

Language: Английский

Citations

0