Cytotoxic Effects of Citrus Peels on Breast Tumor: Opportunities for Waste to Raw Material Conversion
ACS Omega,
Journal Year:
2025,
Volume and Issue:
10(16), P. 16900 - 16908
Published: April 17, 2025
Citrus
species
have
long
been
known
for
their
rich
nutritional
value.
Recent
research
has
shed
light
on
therapeutic
potential,
particularly
in
cancer
treatment.
peels,
the
other
hand,
often
discarded
as
waste,
contain
a
wealth
of
bioactive
compounds,
such
flavonoids,
coumarins,
and
essential
oil
components,
which
proven
medicinal
properties.
Converting
peels
from
waste
products
to
raw
materials
is
crucial
approach
both
healthcare
sustainability.
Therefore,
present
study
aims
investigate
cytotoxic
potential
aurantium
L.,
maxima
(Burm.)
Merr.
(syn.
grandis),
medica
L.
paradisi
Macfad.
cultivated
Türkiye,
find
out
compounds
responsible
activity.
The
effects
peel
extracts
were
evaluated
MCF-7
cell
lines
according
bioactivity-guided
fractionation
isolation
assay
procedures.
CAS-5
(isomeranzin),
CAS-10
(3-methoxy
nobiletin),
CAS-11
(nobiletin),
CAS-12
(tangeretin)
isolated.
In
silico
analyses
conducted
isolated
provided
supporting
information
results
obtained
vitro
experiments
regarding
anticancer
Indeed,
one
key
components
fruits
polymethoxy
flavonoids
(PMFs),
group
constituents
recognized
anti-inflammatory,
antioxidant,
activities.
As
valuable
byproduct
PMFs
offer
dual
benefit
by
reducing
while
providing
natural
source
making
them
an
exciting
area
management.
promise
lies
not
only
ability
combat
but
also
contribute
sustainable
practices.
Language: Английский
Systematic review on effectiveness of flavonoids against hypercholesterolemia: Insights from in-silico, in-vitro, and in-vivo studies
Food Chemistry Advances,
Journal Year:
2025,
Volume and Issue:
7, P. 100981 - 100981
Published: April 21, 2025
Language: Английский
Importance of Advanced Detection Methodologies from Plant Cells to Human Microsystems Targeting Anticancer Applications
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(10), P. 4691 - 4691
Published: May 14, 2025
The
growing
global
demand
for
phytochemicals
as
bioactive
sources
is
prompting
scientists
to
develop
methods
that
link
their
sensory
properties
mechanisms
of
action
in
cancer
treatment.
Recent
techniques
tracking
the
actions
small
plant
metabolites
(SPMs)
from
single-cell
molecular
anticancer
biomarkers
could
provide
valuable
insights
this
field.
Among
critical
discussed
review
are
real-time
cell
components
through
stable
isotope
probing
(Sis)
and
microspectroscopy,
which
has
attracted
attention
biotechnologists.
Additionally,
precise
pathways
required
studying
new
into
functional
materials
discussed,
based
on
high-resolution
accurate
technologies,
aid
categorization.
Notably,
molecules
under
study
have
recently
garnered
applications
due
advancements
effective
evaluation
surpass
traditional
methods.
In
December
2020,
Food
Drug
Administration
(FDA)
authorized
89
SPMs
safe
natural
molecules.
conclusion,
by
combining
spatiotemporal
SPMs’
mechanisms,
they
facilitate
development
more
exceptional,
bio-efficient
materials.
Language: Английский