Cytotoxic Effects of Citrus Peels on Breast Tumor: Opportunities for Waste to Raw Material Conversion
ACS Omega,
Journal Year:
2025,
Volume and Issue:
10(16), P. 16900 - 16908
Published: April 17, 2025
Citrus
species
have
long
been
known
for
their
rich
nutritional
value.
Recent
research
has
shed
light
on
therapeutic
potential,
particularly
in
cancer
treatment.
peels,
the
other
hand,
often
discarded
as
waste,
contain
a
wealth
of
bioactive
compounds,
such
flavonoids,
coumarins,
and
essential
oil
components,
which
proven
medicinal
properties.
Converting
peels
from
waste
products
to
raw
materials
is
crucial
approach
both
healthcare
sustainability.
Therefore,
present
study
aims
investigate
cytotoxic
potential
aurantium
L.,
maxima
(Burm.)
Merr.
(syn.
grandis),
medica
L.
paradisi
Macfad.
cultivated
Türkiye,
find
out
compounds
responsible
activity.
The
effects
peel
extracts
were
evaluated
MCF-7
cell
lines
according
bioactivity-guided
fractionation
isolation
assay
procedures.
CAS-5
(isomeranzin),
CAS-10
(3-methoxy
nobiletin),
CAS-11
(nobiletin),
CAS-12
(tangeretin)
isolated.
In
silico
analyses
conducted
isolated
provided
supporting
information
results
obtained
vitro
experiments
regarding
anticancer
Indeed,
one
key
components
fruits
polymethoxy
flavonoids
(PMFs),
group
constituents
recognized
anti-inflammatory,
antioxidant,
activities.
As
valuable
byproduct
PMFs
offer
dual
benefit
by
reducing
while
providing
natural
source
making
them
an
exciting
area
management.
promise
lies
not
only
ability
combat
but
also
contribute
sustainable
practices.
Language: Английский
Systematic review on effectiveness of flavonoids against hypercholesterolemia: Insights from in-silico, in-vitro, and in-vivo studies
Food Chemistry Advances,
Journal Year:
2025,
Volume and Issue:
7, P. 100981 - 100981
Published: April 21, 2025
Language: Английский
2-Amino-3-Chlorobenzoic Acid from Streptomyces coelicolor: A Cancer Antagonist Targeting PI3K/AKT Markers via miRNA Modulation
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(5), P. 620 - 620
Published: April 24, 2025
Background/Objectives:
Actinomycetes,
particularly
species
within
the
Streptomyces
genus,
are
renowned
for
their
ability
to
produce
a
wide
array
of
bioactive
molecules
with
therapeutic
potential.
This
study
aimed
comprehensively
investigate
antimicrobial
and
anticancer
properties
coelicolor
ERI-15,
particular
focus
on
purified
compound,
2-amino-3-chlorobenzoic
acid
(2A3CB),
its
efficacy
against
microbial
pathogens
breast
cancer
cell
lines.
Methods:
Antimicrobial
compounds
were
produced
through
fermentation
techniques
isolated
via
column
chromatography.
Bioassay-guided
fractionation
was
conducted
Staphylococcus
aureus
(ATCC
25923),
methicillin-resistant
(MRSA),
Escherichia
coli
25922),
Bacillus
subtilis
441).
Major
fractions
further
using
preparative
thin-layer
chromatography
(TLC).
The
structures
active
elucidated
spectral
analyses
including
IR,
mass
spectrometry,
1H/13C
NMR.
compound
2A3CB
(m/z
171)
tested
MDA-MB-231
3T3
Cytotoxicity
assessed
by
MTT
assay,
apoptotic
mechanisms
explored
proliferation
assays,
dual
fluorescent
staining,
migration
invasion
analysis
markers
at
mRNA
protein
levels.
Results:
exhibited
strong
cytotoxic
effects
cells,
IC50
values
26
µM,
5
7.2
µM
24,
48,
72
h,
respectively.
It
significantly
inhibited
migration,
induced
apoptosis
caspase-mediated
pathways.
Expression
levels
PTEN,
PCNA,
BAX,
STAT3
downregulated,
suggesting
inhibition
metastasis
suppression
migration.
Conclusions:
results
demonstrate
that
2A3CB,
derived
from
S.
possesses
potent
properties.
Its
inhibit
growth
induce
in
cells
highlights
potential
as
natural
candidate
targeted
treatment,
progression.
Language: Английский
Importance of Advanced Detection Methodologies from Plant Cells to Human Microsystems Targeting Anticancer Applications
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(10), P. 4691 - 4691
Published: May 14, 2025
The
growing
global
demand
for
phytochemicals
as
bioactive
sources
is
prompting
scientists
to
develop
methods
that
link
their
sensory
properties
mechanisms
of
action
in
cancer
treatment.
Recent
techniques
tracking
the
actions
small
plant
metabolites
(SPMs)
from
single-cell
molecular
anticancer
biomarkers
could
provide
valuable
insights
this
field.
Among
critical
discussed
review
are
real-time
cell
components
through
stable
isotope
probing
(Sis)
and
microspectroscopy,
which
has
attracted
attention
biotechnologists.
Additionally,
precise
pathways
required
studying
new
into
functional
materials
discussed,
based
on
high-resolution
accurate
technologies,
aid
categorization.
Notably,
molecules
under
study
have
recently
garnered
applications
due
advancements
effective
evaluation
surpass
traditional
methods.
In
December
2020,
Food
Drug
Administration
(FDA)
authorized
89
SPMs
safe
natural
molecules.
conclusion,
by
combining
spatiotemporal
SPMs'
mechanisms,
they
facilitate
development
more
exceptional,
bio-efficient
materials.
Language: Английский
Effects of Grape By-Products on Oxidative Stress and Inflammation in Farm Animals: An Overview of Studies Performed in Pigs, Chickens, and Cattle
Animals,
Journal Year:
2025,
Volume and Issue:
15(11), P. 1536 - 1536
Published: May 23, 2025
High-yielding
farm
animals
often
face
severe
metabolic
stress,
compounded
by
environmental
stressors
such
as
psychosocial
heat
intensive
housing
systems,
and
poor
hygiene
management.
These
factors
result
in
oxidative
stress
inflammatory
processes,
which
adversely
affect
both
animal
health
performance.
Polyphenols
are
known
to
alleviate
responses.
Since
grapes
rich
polyphenols,
by-products
of
winemaking
could
have
beneficial
effects
on
these
processes.
This
review
aims
provide
an
overview
the
potential
antioxidative
anti-inflammatory
grape
animals.
The
first
section
examines
causes
consequences
inflammation.
second
highlights
general
polyphenols
addressing
issues.
third
central
part
presents
findings
from
studies
investigating
impact
various
grape-derived
antioxidant
system
inflammation
pigs,
chicken,
cattle.
Overall,
demonstrate
that
can
effectively
reduce
pigs
chickens,
leading
improved
In
cattle,
however,
fewer
been
conducted,
results
regarding
less
consistent.
conclusion,
represent
valuable
feed
options
for
preventing
monogastric
(pigs,
chickens).
Language: Английский
Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight
International Journal of Food Science,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
Due
to
the
increasing
rate
of
cancer
and
undesirable
consequences
manufactured
drugs,
there
is
a
growing
interest
in
development
natural
products
as
potential
remedies.
Ferulic
acid
(FA),
phenolic
substance,
found
naturally
present
Ferula
foetida
plant’s
cell
walls
with
therapeutic
activities.
The
objective
this
study
determine
botanical
sources,
pharmacokinetics,
anticancer
activity
FA
its
derivatives,
focusing
on
molecular
mechanism
by
using
data
obtained
from
literature
database.
study’s
findings
suggest
that
demonstrates
promising
effects
preclinical
pharmacological
test
methods.
exhibit
showed
through
underlying
mechanisms,
including
induction
oxidative
stress,
cytotoxic
effect,
cycle
arrest,
apoptotic
suppression
invasion
migration,
antiproliferative
autophagy,
genotoxic
mutagenic
effect
regulating
different
pathways
like
PI3K/AKT,
p38/MAPK/ERK,
AKT/mTOR,
NF‐
κ
B
signaling
which
are
involved
growth.
Additionally,
review
indicated
pharmacokinetic
properties
FA,
indicating
lower
oral
bioavailability
affected
liver’s
fast
conjugation
process;
limitation
overcome
applying
nanoformulation
FA.
However,
additional
clinical
investigations
recommended
appropriate
effectiveness,
safety,
human
dosage.
Language: Английский
Exploring 5,7-dimethoxyflavone from Piper ornatum as a novel anti-breast cancer candidate: insights from in silico analysis
Brazilian Journal of Biology,
Journal Year:
2025,
Volume and Issue:
85
Published: Jan. 1, 2025
This
study
investigates
the
potential
of
compound
5,7-dimethoxyflavone
(5,7-DMF)
found
in
Piper
ornatum
as
an
anti-breast
cancer
agent
using
silico
approach.
The
targeted
three
major
mechanisms
involved
breast
progression:
ability
5,7-DMF
to
inhibit
kinase
activity,
act
a
competitive
inhibitor
cyclooxygenase
2
(COX-2)
and
nitric
oxide
synthase
(NOS2).
was
investigated
through
molecular
simulation
by
assessing
drug-likeness,
toxicity,
membrane
permeability,
bioactivity,
specific
docking
with
AutoDock
Vina
integrated
PyRx
8.0,
well
dynamics
CABS-flex
2.0.
Molecular
results
showed
that
has
high
binding
affinity
towards
COX-2
target
inhibits
activity.
also
revealed
significant
interactions
between
active
site,
supporting
its
agent.
These
provide
solid
basis
for
further
development
drug
candidate
against
cancer.
Language: Английский