Acid Sphingomyelinase and Ceramide Signaling Pathway Mediates Nicotine-Induced NLRP3 Inflammasome Activation and Podocyte Injury

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 416 - 416

Published: Feb. 9, 2025

Background: Recent studies have shown that Nlrp3 inflammasome activation is importantly involved in podocyte dysfunction induced by nicotine. The present study was designed to test whether acid sphingomyelinase (Asm) and ceramide signaling play a role mediating nicotine-induced subsequent damage. Methods Results: Nicotine treatment significantly increased the Asm expression production compared control cells. However, prior with amitriptyline, an inhibitor attenuated production. Confocal microscopic biochemical analyses showed nicotine colocalization of NLRP3 Asc, vs. caspase-1, IL-1β production, caspase-1 activity, desmin podocytes Pretreatment amitriptyline abolished activity expression. Immunofluorescence decreased podocin reduction. In addition, cell permeability, O2 apoptosis podocytes. Conclusions: one important mediators injury. may be therapeutic target for or prevention glomerulosclerosis associated smoking.

Language: Английский

Understanding the Role of Adipokines in Cardiometabolic Dysfunction: A Review of Current Knowledge

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 612 - 612

Published: April 23, 2025

Cardiometabolic risk and associated dysfunctions contribute largely to the recent rise in mortality globally. Advancements multi-omics years promise a better understanding of potential biomarkers that enable an early diagnosis cardiometabolic dysfunction. However, molecular mechanisms driving onset progression disorders remain poorly understood. Adipokines are adipocyte-specific cytokines central deleterious alterations. They exhibit both pro-inflammatory anti-inflammatory effects, complicating their association with disturbances. Thus, adipokines from signaling perspective assumes great importance. This review presents comprehensive outline most prominent exhibiting and/or functions The also insight into pathophysiological implications such different dysfunction conditions, status adipokine druggability, future studies can be undertaken address existing scientific gap. A clear functional mechanistic role potentially improve our cardiovascular disease pathophysiology enhance current therapeutic regimen come.

Language: Английский

Mitigation of nicotine-induced podocyte injury through inhibition of thioredoxin interacting protein

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118110 - 118110

Published: May 1, 2025

Language: Английский