G-Protein-Coupled Receptors in Chronic Kidney Disease Induced by Hypertension and Diabetes DOI Creative Commons

Huidi Tang,

Kang Li, Zhan Shi

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(10), P. 729 - 729

Published: May 16, 2025

Hypertension and diabetes are two common causes of chronic kidney disease. can induce renal vascular injury, glomerular damage, podocyte loss, tubular leading to tubulointerstitial fibrosis. A number factors influence the regulation hypertension, among which G-protein-coupled receptors (GPCRs) have been studied extensively because they desirable targets for drug development. Compared regulatory effects GPCRs on hypertensive disease (HKD) less generalized. In this review, we discussed involved in disease, such as angiotensin II (AT1R AT2R), Mas receptor (MasR), Mas-related member D (MrgD), relaxin family 1 (RXFP1), adenosine (A1, A2A, A2B, A3), purinergic P2Y receptors, endothelin (ETA ETB). The progression HKD is rarely reversed but be retarded by ameliorating microenvironment kidneys. However, simply reducing blood pressure cannot stop HKD. Diabetic nephropathy (DN) most cause end-stage (ESRD), a major morbidity mortality diabetes. Many DN. Here, select some well-studied that directly associated with pathogenesis DN illustrate their mechanisms. main purpose review provide an overview occurrence probable pathophysiological mechanisms, hope will help developing new therapeutic strategies.

Language: Английский

G-Protein-Coupled Receptors in Chronic Kidney Disease Induced by Hypertension and Diabetes DOI Creative Commons

Huidi Tang,

Kang Li, Zhan Shi

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(10), P. 729 - 729

Published: May 16, 2025

Hypertension and diabetes are two common causes of chronic kidney disease. can induce renal vascular injury, glomerular damage, podocyte loss, tubular leading to tubulointerstitial fibrosis. A number factors influence the regulation hypertension, among which G-protein-coupled receptors (GPCRs) have been studied extensively because they desirable targets for drug development. Compared regulatory effects GPCRs on hypertensive disease (HKD) less generalized. In this review, we discussed involved in disease, such as angiotensin II (AT1R AT2R), Mas receptor (MasR), Mas-related member D (MrgD), relaxin family 1 (RXFP1), adenosine (A1, A2A, A2B, A3), purinergic P2Y receptors, endothelin (ETA ETB). The progression HKD is rarely reversed but be retarded by ameliorating microenvironment kidneys. However, simply reducing blood pressure cannot stop HKD. Diabetic nephropathy (DN) most cause end-stage (ESRD), a major morbidity mortality diabetes. Many DN. Here, select some well-studied that directly associated with pathogenesis DN illustrate their mechanisms. main purpose review provide an overview occurrence probable pathophysiological mechanisms, hope will help developing new therapeutic strategies.

Language: Английский

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