Targeting Redox Signaling Through Exosomal MicroRNA: Insights into Tumor Microenvironment and Precision Oncology DOI Creative Commons
Moon Nyeo Park,

Myoungchan Kim,

Soojin Lee

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 501 - 501

Published: April 22, 2025

Reactive oxygen species (ROS) play a dual role in cancer progression, acting as both signaling molecules and drivers of oxidative damage. Emerging evidence highlights the intricate interplay between ROS, microRNAs (miRNAs), exosomes within tumor microenvironment (TME), forming regulatory axis that modulates immune responses, angiogenesis, therapeutic resistance. In particular, stress not only stimulates exosome biogenesis but also influences selective packaging redox-sensitive miRNAs (miR-21, miR-155, miR-210) via RNA-binding proteins such hnRNPA2B1 SYNCRIP. These miRNAs, delivered through exosomes, alter gene expression recipient cells promote tumor-supportive phenotypes M2 macrophage polarization, CD8+ T-cell suppression, endothelial remodeling. This review systematically explores how this ROS–miRNA–exosome orchestrates communication across stromal cell populations under hypoxic inflammatory conditions. Particular emphasis is placed on NADPH oxidases, hypoxia-inducible factors, autophagy-related mechanisms regulating exosomal output. addition, we analyze relevance natural products herbal compounds—such curcumin, resveratrol, ginsenosides—which have demonstrated promising capabilities to modulate ROS levels, miRNA expression, dynamics. We further discuss clinical potential leveraging for therapy, including strategies involving mesenchymal stem cell-derived ferroptosis regulation, miRNA-based modulation. Incorporating insights from spatial transcriptomics single-cell analysis, provides mechanistic foundation development exosome-centered, redox-modulating therapeutics. Ultimately, work aims guide future research drug discovery efforts toward integrating medicine redox biology fight against cancer.

Language: Английский

Targeting Redox Signaling Through Exosomal MicroRNA: Insights into Tumor Microenvironment and Precision Oncology DOI Creative Commons
Moon Nyeo Park,

Myoungchan Kim,

Soojin Lee

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 501 - 501

Published: April 22, 2025

Reactive oxygen species (ROS) play a dual role in cancer progression, acting as both signaling molecules and drivers of oxidative damage. Emerging evidence highlights the intricate interplay between ROS, microRNAs (miRNAs), exosomes within tumor microenvironment (TME), forming regulatory axis that modulates immune responses, angiogenesis, therapeutic resistance. In particular, stress not only stimulates exosome biogenesis but also influences selective packaging redox-sensitive miRNAs (miR-21, miR-155, miR-210) via RNA-binding proteins such hnRNPA2B1 SYNCRIP. These miRNAs, delivered through exosomes, alter gene expression recipient cells promote tumor-supportive phenotypes M2 macrophage polarization, CD8+ T-cell suppression, endothelial remodeling. This review systematically explores how this ROS–miRNA–exosome orchestrates communication across stromal cell populations under hypoxic inflammatory conditions. Particular emphasis is placed on NADPH oxidases, hypoxia-inducible factors, autophagy-related mechanisms regulating exosomal output. addition, we analyze relevance natural products herbal compounds—such curcumin, resveratrol, ginsenosides—which have demonstrated promising capabilities to modulate ROS levels, miRNA expression, dynamics. We further discuss clinical potential leveraging for therapy, including strategies involving mesenchymal stem cell-derived ferroptosis regulation, miRNA-based modulation. Incorporating insights from spatial transcriptomics single-cell analysis, provides mechanistic foundation development exosome-centered, redox-modulating therapeutics. Ultimately, work aims guide future research drug discovery efforts toward integrating medicine redox biology fight against cancer.

Language: Английский

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