Detection of the genetic association of circulating Helicobacter pylori antibodies with atrial fibrillation DOI Creative Commons
Xizhi Wang,

Tianxiang Fang,

Wen‐Jun Shen

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(20), P. e42506 - e42506

Published: May 16, 2025

Helicobacter pylori (H pylori) infection and H antibodies have been reported to be associated with an increased risk of atrial fibrillation (AF) in several observational studies. However, whether this relationship is causal which serve as the determinant AF remains largely unclear. Recently published Genome-wide association studies on 7 different pylori-specific proteins (2 correction methods) were included study. A two-sample Mendelian randomization study was employed investigate effects circulating AF. Genetically predicted serum Catalase antibody level (Firth correction) (odds ratio = 1.137, 95% confidence interval: 1.008-1.282, P .037) (saddlepoint approximation 1.139, 1.010-1.284, .034). No significant correlations found between other This demonstrates that only terms pylori-related antibodies.

Language: Английский

Detection of the genetic association of circulating Helicobacter pylori antibodies with atrial fibrillation DOI Creative Commons
Xizhi Wang,

Tianxiang Fang,

Wen‐Jun Shen

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(20), P. e42506 - e42506

Published: May 16, 2025

Helicobacter pylori (H pylori) infection and H antibodies have been reported to be associated with an increased risk of atrial fibrillation (AF) in several observational studies. However, whether this relationship is causal which serve as the determinant AF remains largely unclear. Recently published Genome-wide association studies on 7 different pylori-specific proteins (2 correction methods) were included study. A two-sample Mendelian randomization study was employed investigate effects circulating AF. Genetically predicted serum Catalase antibody level (Firth correction) (odds ratio = 1.137, 95% confidence interval: 1.008-1.282, P .037) (saddlepoint approximation 1.139, 1.010-1.284, .034). No significant correlations found between other This demonstrates that only terms pylori-related antibodies.

Language: Английский

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