Immunotherapy in chronic lymphocytic leukemia: advances and challenges DOI Creative Commons
Pan Gao, Yang Zhang, Jun Ma

et al.

Experimental Hematology and Oncology, Journal Year: 2025, Volume and Issue: 14(1)

Published: April 10, 2025

Abstract Chronic lymphocytic leukemia (CLL) is characterized as a clonal proliferation of mature B lymphocytes with distinct immunophenotypic traits, predominantly affecting the middle-aged and elderly population. This condition marked by an accumulation within peripheral blood, bone marrow, spleen, lymph nodes. The associated immune dysregulation predisposes CLL patients to higher risk secondary malignancies infections, which significantly contribute morbidity mortality rates. advent immunotherapy has revolutionized prognosis CLL, advancing treatment modalities offering substantial benefits patient outcomes. review endeavors synthesize scrutinize efficacy, merits, limitations current immunotherapeutic strategies for CLL. aim inform selection optimal regimens tailored individual needs. Furthermore, juxtaposes various therapeutic combinations elucidate comparative advantages each approach, ultimate objective enhancing quality life.

Language: Английский

Immunotherapy in chronic lymphocytic leukemia: advances and challenges DOI Creative Commons
Pan Gao, Yang Zhang, Jun Ma

et al.

Experimental Hematology and Oncology, Journal Year: 2025, Volume and Issue: 14(1)

Published: April 10, 2025

Abstract Chronic lymphocytic leukemia (CLL) is characterized as a clonal proliferation of mature B lymphocytes with distinct immunophenotypic traits, predominantly affecting the middle-aged and elderly population. This condition marked by an accumulation within peripheral blood, bone marrow, spleen, lymph nodes. The associated immune dysregulation predisposes CLL patients to higher risk secondary malignancies infections, which significantly contribute morbidity mortality rates. advent immunotherapy has revolutionized prognosis CLL, advancing treatment modalities offering substantial benefits patient outcomes. review endeavors synthesize scrutinize efficacy, merits, limitations current immunotherapeutic strategies for CLL. aim inform selection optimal regimens tailored individual needs. Furthermore, juxtaposes various therapeutic combinations elucidate comparative advantages each approach, ultimate objective enhancing quality life.

Language: Английский

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