Cognitive Impairment and Its Associated Factors in Older Adults Living in High and Low Altitude Areas: A Comparative Study

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: June 23, 2022

Background Cognitive impairment is a major health concern in older adults. Few studies have examined the association between environmental factors and cognitive impairment, especially high altitude areas. In this study, prevalence of adults living was compared with those low Methods This comparative study conducted at Qinghai (high group), Guangzhou (low China. Cognition, depressive symptoms quality life (QOL) were assessed using Montreal Assessment (MoCA), Patient Health Questionnaire (PHQ-9) WHO Quality Life brief version–WHOQOL-BREF, respectively. Results Altogether, 644 (207 437 Guangzhou) completed assessment. The rate 94.7% (95% CI: 91.6–97.7%) area, while corresponding figure 89.2% 86.3–92.1%) area. After controlling for covariates, group appeared more likely to (OR = 2.92, 95% 1.23–6.91, P 0.015) group. Within sample, multinomial logistic regression analysis revealed that age (aged 74 above) significantly associated higher risk severe 3.58, 95%CI: 1.44–8.93, 0.006), education level (secondary school decreased moderate 0.43, 0.22–0.85, 0.006). group, QOL did not differ normal/mild, subgroups across physical [ F (1, 207) 1.83, 0.163], psychological 1.50, 0.225], social (1,207) 2.22, 0.111] domains 0.49, 0.614]. Conclusion found common among Regular screening appropriate interventions should be provided need.

Language: Английский

---

Acute high altitude exposure, acclimatization and re-exposure on nocturnal breathing

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 5, 2022

Background: Effects of prolonged and repeated high-altitude exposure on oxygenation control breathing remain uncertain. We hypothesized that will improve altitude-induced deoxygenation instability. Methods: 21 healthy lowlanders, aged 18-30y, underwent two 7-day sojourns at a station in Chile (4-8 hrs/day 5,050 m, nights 2,900 m), separated by 1-week recovery period 520 m. Respiratory sleep studies recording mean nocturnal pulse oximetry (SpO2), oxygen desaturation index (ODI, >3% dips SpO2), patterns subjective quality visual analog scale (SQ-VAS, 0-100% with increasing quality), were evaluated m during 1 6 the 1st 2nd altitude sojourn. Results: At ± SD SpO2 was 94 1%, ODI 2.2 1.2/h, SQ-VAS 59 20%. Corresponding values sojourn, night were: 86 2%, 23.4 22.8/h, 39 23%; 6: 90 7.3 4.4/h, 55 20% (p < 0.05, all differences within corresponding variables). Mean (Δ, 95%CI) acute effects (2,900 1, vs m) between sojourn ΔSpO2 0% (-1 to 1), ΔODI -9.2/h (-18.0 -0.5), ΔSQ-VAS 10% (-6 27); acclimatization (changes -1% (-2 0), 11.1/h (2.5 19.7), -15% (-31 1). Conclusion: Acute induced hypoxemia, cyclic deoxygenations impaired quality. Acclimatization mitigated these effects. After diminished high-altitude-induced instability, suggesting some retention adaptation first while remained similarly impaired.

Language: Английский

---

Effect of acetazolamide on visuomotor performance at high altitude in healthy people 40 years of age or older—RCT

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(1), P. e0280585 - e0280585

Published: Jan. 20, 2023

Altitude travel is increasingly popular also for middle-aged and older tourists professionals. Due to the sensitivity of central nervous system hypoxia, altitude exposure may impair visuomotor performance although this has not been extensively studied. Therefore, we investigated whether a sojourn at moderately high associated with impairments in healthy adults, 40y age or older, adverse altitude-effect can be prevented by acetazolamide, drug used prevent acute mountain sickness.In randomized placebo-controlled parallel-design trial, 59 lowlanders, aged 40-75y, were assigned acetazolamide (375 mg/day, n = 34) placebo (n 25), administered one day before ascent while staying (3100m). Visuomotor was assessed 760m 3100m after arrival next morning (post-sleep) computer-assisted test (Motor-Task-Manager). It quantified deviation participant-controlled cursor affected rotation during target tracking. Primary outcome directional error post-sleep recall adaptation estimated multilevel linear regression modeling. Additionally, adaptation, immediate recall, correct execution evaluated.Compared 760m, assessments revealed mean (95%CI) increase 1.9° (0.2 3.5, p 0.024) 1.1° (0.4 1.8, 0.002), respectively. Post-sleep remained unchanged (p NS), however 14% less likely (9 19, p<0.001). Acetazolamide improved 5.6° (2.6 8.6, p<0.001) probability 36% (30 42, compared placebo.In individuals, impaired task. Preventive treatment night increased placebo.ClinicalTrials.gov NCT03536520.

Language: Английский

---

The change of attention network functions and physiological adaptation during high-altitude hypoxia and reoxygenation

Physiology & Behavior, Journal Year: 2023, Volume and Issue: 268, P. 114240 - 114240

Published: May 16, 2023

Language: Английский

---

Intensity-dependent acute aerobic exercise: Effect on reactive control of attentional functions in acclimatized lowlanders at high altitude

Physiology & Behavior, Journal Year: 2022, Volume and Issue: 250, P. 113785 - 113785

Published: March 26, 2022

Language: Английский

---