Cited by Residue of thiram in food, suppresses immune system stress signals and disturbs sphingolipid metabolism in chickens

Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance DOI

Sepideh Mirzaei, Aliasghar Tabatabaei Mohammadi, Mohammad Gholami

et al.

Pharmacological Research, Journal Year: 2021, Volume and Issue: 167, P. 105575 - 105575

Published: March 24, 2021

Language: Английский

Citations

121

Transition of acute kidney injury to chronic kidney disease: role of metabolic reprogramming DOI

Zijing Zhu, Jijia Hu, Zhaowei Chen

et al.

Metabolism, Journal Year: 2022, Volume and Issue: 131, P. 155194 - 155194

Published: March 26, 2022

Language: Английский

Citations

102

Is Autophagy Always a Barrier to Cisplatin Therapy? DOI

Jingwen Xu, David A. Gewirtz

Biomolecules, Journal Year: 2022, Volume and Issue: 12(3), P. 463 - 463

Published: March 17, 2022

Cisplatin has long been a first-line chemotherapeutic agent in the treatment of cancer, largely for solid tumors. During course past two decades, autophagy identified response to cancer treatments and almost uniformly detected studies involving cisplatin. There increasing recognition as critical factor affecting tumor cell death chemoresistance. In this review commentary, we introduce four mechanisms resistance cisplatin followed by discussion factors that affect role cisplatin-sensitive resistant cells explore two-sided outcomes occur when inhibitors are combined with Our goal is analyze potential combinatorial use clinic.

Language: Английский

Citations

Nitazoxanide and COVID-19: A review DOI

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Engy Elekhnawy

et al.

Molecular Biology Reports, Journal Year: 2022, Volume and Issue: 49(11), P. 11169 - 11176

Published: Sept. 12, 2022

Language: Английский

Citations

Esketamine is neuroprotective against traumatic brain injury through its modulation of autophagy and oxidative stress via AMPK/mTOR-dependent TFEB nuclear translocation DOI

Tang Yanbin,

Yufang Liu,

Huanzhu Zhou

et al.

Experimental Neurology, Journal Year: 2023, Volume and Issue: 366, P. 114436 - 114436

Published: May 13, 2023

Language: Английский

Citations

Cyanidin-3-glucoside inhibits ferroptosis in renal tubular cells after ischemia/reperfusion injury via the AMPK pathway DOI

Yiwei Du, Xiao‐Kang Li, Tingting Wang

et al.

Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(1)

Published: April 3, 2023

Abstract Background Ferroptosis, which is characterized by lipid peroxidation and iron accumulation, closely associated with the pathogenesis of acute renal injury (AKI). Cyanidin-3-glucoside (C3G), a typical flavonoid that has anti-inflammatory antioxidant effects on ischemia‒reperfusion (I/R) injury, can induce AMP-activated protein kinase (AMPK) activation. This study aimed to show C3G exerts nephroprotective against I/R-AKI related ferroptosis regulating AMPK pathway. Methods Hypoxia/reoxygenation (H/R)-induced HK-2 cells mice were treated or without inhibiting AMPK. The level intracellular free iron, expression ferroptosis-related proteins acyl-CoA synthetase long chain family member 4 (ACSL4) glutathione peroxidase (GPX4), levels markers 4-hydroxynonenal (4-HNE), reactive oxygen species (ROS) malondialdehyde (MDA) examined. Results We observed inhibitory effect in vitro vivo, was reversion excessive decrease 4-HNE, ROS, MDA ACSL4 expression, an increase GPX4 (GSH) levels. Notably, inhibition CC significantly abrogated models vivo vitro. Conclusion Our results provide new insight into activating

Language: Английский

Citations

TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy DOI

Binfeng Yu,

Lini Jin,

Xi Yao

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(13), P. 4356 - 4375

Published: Jan. 1, 2023

Background: Cisplatin is a widely used anti-tumor agent but its use frequently limited by nephrotoxicity.Transient receptor potential melastatin 2 (TRPM2) non-selective cation channel which generally viewed as sensor of oxidative stress, and increasing evidence supports link with autophagy, critical process for organelle homeostasis.Methods: Cisplatin-induced cell injury mitochondrial damage were both assessed in WT Trpm2-knockout mice primary cells.RNA sequencing, immunofluorescence staining, immunoblotting flowcytometry applied to interpret the mechanism TRPM2 cisplatin nephrotoxicity.Results: Knockout exacerbates renal dysfunction, tubular apoptosis model acute kidney (AKI) induced treatment cisplatin.Cisplatin-caused aggravated TRPM2-deficient cells and, conversely, alleviated Mito-TEMPO, ROS scavenger.TRPM2 deficiency hinders cisplatin-induced autophagy via blockage Ca 2+ influx subsequent up-regulation AKT-mTOR signaling.Consistently, damage, dysfunction are mitigated mTOR inhibitor.Conclusion: Our results suggest that plays protective role AKI modulating -AKT-mTOR signaling pathway providing novel insights into pathogenesis injury.

Language: Английский

Citations

Kaempferide ameliorates cisplatin-induced nephrotoxicity via inhibiting oxidative stress and inducing autophagy DOI

Yanfei Shao,

Bingbing Tang,

Yu-hui Ding

et al.

Acta Pharmacologica Sinica, Journal Year: 2023, Volume and Issue: 44(7), P. 1442 - 1454

Published: Jan. 19, 2023

Language: Английский

Citations

Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway DOI

Yuhan Zhang, Mengnan Zeng, Benke Li

et al.

Chinese Journal of Natural Medicines, Journal Year: 2023, Volume and Issue: 21(5), P. 371 - 382

Published: May 1, 2023

Language: Английский

Citations

Role of renal tubular epithelial cells and macrophages in cisplatin-induced acute renal injury DOI

Jinzhang Gao,

Qinxiang Deng,

Jun Yu

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 339, P. 122450 - 122450

Published: Jan. 21, 2024

Language: Английский

Citations