Role of Myokines and prospects for their role in Diabetes Mellitus Therapy DOI

Kharissova Nuriya,

Mindubaуeva Farida,

RK Sharma

et al.

Research Journal of Pharmacy and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 5119 - 5131

Published: Oct. 22, 2024

In the last decade, attention of researchers has been drawn to ability skeletal muscles produce biologically active substances (myokines). To date, several hundred myokines have identified in muscle secretome. Myokines autocrine and paracrine effects. They their own receptors various tissues organs. At certain concentrations, a systemic effect on organs, provide metabolic interaction between them huge range physiological However, biological activity many these mechanism action are either not yet characterized or poorly understood. Modern research is aimed at developing drugs that block myokine signaling pathways studying possibilities use treatment neuromuscular diseases, obesity, type 2 diabetes mellitus, orthopedic pathology, as well decrease mass strength. Type mellitus (T2DM) socially significant disease. Currently, there no effective therapy completely eradicate/cure its associated complications. It now necessary consider more detail molecular targets for each pharmacological drug. There need create new anti-diabetic future based myokines, knowing target cells, but also best possible combination strategies using available beneficial effects physical exercise prevention T2DM. A few studies mice humans shown increases levels numerous blood plasma, leading process transcription accelerating processes with increased load tissue. suggested secretion depends degree training; intensity duration athlete’s anatomical structure; sport which athlete plays. Further scientific will key understanding (proteins) body organs/systems tissues, undoubtedly contribute success doctors field practical healthcare correction pathological disorders, including mellitus.

Language: Английский

Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy DOI Creative Commons

Ren Jie Phang,

Rebecca H. Ritchie, Derek J. Hausenloy

et al.

Cardiovascular Research, Journal Year: 2022, Volume and Issue: 119(3), P. 668 - 690

Published: April 7, 2022

Abstract Patients with Type 2 diabetes mellitus (T2DM) frequently exhibit a distinctive cardiac phenotype known as diabetic cardiomyopathy. Cardiac complications associated T2DM include inflammation, hypertrophy, fibrosis, and diastolic dysfunction in the early stages of disease, which can progress to systolic heart failure. Effective therapeutic options for cardiomyopathy are limited often have conflicting results. The lack effective treatments is due part, our poor understanding disease development progression, well robust valid preclinical human models that accurately recapitulate pathophysiology heart. In addition cardiomyocytes, contains heterogeneous population non-myocytes including fibroblasts, vascular cells, autonomic neurons, immune cells. These play important roles homeostasis yet effect hyperglycaemia hyperlipidaemia on these cell types overlooked advent human-induced pluripotent stem cells provides new paradigm model they be differentiated into all This review will discuss their dynamic intercellular interactions pathogenesis We also use sodium-glucose cotransporter inhibitors therapy impacts non-myocytes. developments no doubt facilitate discovery novel treatment targets preventing onset progression

Language: Английский

Citations

32
Organokines in Rheumatoid Arthritis: A Critical Review DOI Open Access
Lucas Fornari Laurindo,

Mariana Canevari de Maio,

Sandra Maria Barbalho

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(11), P. 6193 - 6193

Published: May 31, 2022

Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects the joints. Organokines can produce beneficial or harmful effects in this condition. Among RA patients, organokines have been associated with increased inflammation and cartilage degradation due to augmented cytokines metalloproteinases production, respectively. This study aimed perform review investigate role of adipokines, osteokines, myokines, hepatokines on progression. PubMed, Embase, Google Scholar, Cochrane were searched, 18 studies selected, comprising more than 17,000 patients. Changes pattern secretion identified, these could directly indirectly contribute aggravating RA, promoting articular alterations, predicting activity. In addition, implicated higher radiographic damage, immune dysregulation, angiogenesis. These also act as potent regulators cells proliferation, differentiation, apoptosis, controlling osteoclasts, chondrocytes, fibroblasts well chemotaxis sites. Although much already known, still unknown, principally about roles occurrence extra-articular manifestations.

Language: Английский

Citations

22
The Role of Chemokines in Obesity and Exercise-Induced Weight Loss DOI Creative Commons

Wenbi He,

Huan Wang, Gaoyuan Yang

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1121 - 1121

Published: Sept. 4, 2024

Obesity is a global health crisis that closely interrelated to many chronic diseases, such as cardiovascular disease and diabetes. This review provides an in-depth analysis of specific chemokines involved in the development obesity, including C-C motif chemokine ligand 2 (CCL2), CCL3, CCL5, CCL7, C-X-C 8 (CXCL8), CXCL9, CXCL10, CXCL14, XCL1 (lymphotactin). These exacerbate symptoms obesity by either promoting inflammatory response or influencing metabolic pathways recruiting immune cells. Additionally, research highlights positive effect exercise on modulating expression obese state. Notably, it explores potential effects both aerobic exercises combined resistance training lowering levels mediators, reducing insulin resistance, improving health. findings suggest new strategies for intervention through modulation exercise, providing fresh perspectives directions treatment future research.

Language: Английский

Citations

3
Effect of Virtual Reality on Balance Function in Children With Cerebral Palsy: A Systematic Review and Meta-analysis DOI Creative Commons
Wei Liu,

Yuanyan Hu,

Junfeng Li

et al.

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: April 25, 2022

Virtual Reality (VR) therapy is popular in treating children with Cerebral Palsy (CP) as a new technology for rehabilitation. Nevertheless, no substantial evidence supporting VR promotion has been developed to date. This study aimed investigate the effects of on balance CP. We conducted systematic search PubMed and Web Science (updated December 30, 2021). The review meta-analysis included all randomized controlled trials that A total 18 RCT studies were eligible inclusion review, was performed 16 them. Results showed intervention beneficial (SMD 0.47 [95% CI, SD 0.28, 0.66]). concluded interventions CP have positive effects. However, cautious implementation needed clinical applications.

Language: Английский

Citations

11
Role of Myostatin in Rheumatoid Arthritis: A Review of the Clinical Impact DOI Creative Commons
Fabiola González-Ponce, Melissa Ramírez-Villafaña, Eli Efraín Gómez-Ramírez

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(11), P. 1085 - 1085

Published: May 23, 2024

Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects synovial joints and frequently involves extra-articular organs. A multiplicity of interleukins (IL) participates in the pathogenesis RA, including IL-6, IL-1β, transforming growth factor-beta (TGF-β), tumor necrosis factor (TNF)-α; immune cells such as monocytes, T B lymphocytes, macrophages; auto-antibodies, mainly rheumatoid anti-citrullinated protein antibodies (ACPAs). Skeletal muscle also involved with many patients developing wasting sarcopenia. Several mechanisms are myopenia observed one them includes effects some myokines on myocytes. Myostatin myokine member TGF-β superfamily; overproduction myostatin acts negative regulator differentiates fibers, limiting their number size. Recent studies have identified abnormalities serum levels RA patients, these been found to be associated other manifestations severe RA. This review analyzes recent information regarding relationship between clinical relevance therapeutic target for future research.

Language: Английский

Citations

2
Muscle–brain crosstalk mediated by exercise-induced myokines - insights from experimental studies DOI Creative Commons

Magdalena Kostka,

Julia Morys, Andrzej Małecki

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

Over the past couple of decades, it has become apparent that skeletal muscles might be engaged in endocrine signaling, mostly as a result exercise or physical activity general. The importance this phenomenon is currently studied terms impact exercise- -induced signaling factors have, interaction "muscle-brain crosstalk." So far, muscle-derived myokines were demonstrated to intercede connection between and plethora various organs such adipose tissue, liver, pancreas. However, exact mechanism muscle-brain communication yet determined. It speculated that, particular, brain-derived neurotrophic factor (BDNF), irisin, cathepsin B (CTSB), interleukin 6 (IL-6), insulin-like growth factor-1 (IGF-1) partake crosstalk by promoting neuronal proliferation synaptic plasticity, also resulting improved cognition ameliorated behavioral alterations. Researchers suggest act directly on brain parenchyma via crossing blood-brain barrier (BBB). following article reviews information available regarding rodent studies main determined cross BBB, specifically addressing association exercise-induced myokine release central nervous system (CNS) impairments. Although hypothesis being critical sources seems promising, should not forgotten origin these vary, depending cell types their synthesis. Limited amount research providing alterations expression at same time, results taking them only circumstantial evidence way determine actual involvement overall state homeostasis. CNS

Language: Английский

Citations

1
Effects of Treadmill Running at Different Light Cycles in Mice with Metabolic Disorders DOI Open Access
А. Н. Захарова, К. Г. Милованова, А. А. Орлова

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15132 - 15132

Published: Oct. 13, 2023

Type 2 diabetes mellitus accounts for about 90% of cases and is considered one the most important problems our time. Despite a significant number studies on glucose metabolism, molecular mechanisms its regulation in health disease remain insufficiently studied. That why non-drug treatment metabolic disorders great relevance, including physical activity. Metabolic changes under influence activity are very complex still difficult to understand. This study aims deepen understanding effect exercise mice with mellitus. We studied forced treadmill running body weight parameters disorders. developed high-fat-diet-induced diabetic model exposed 4 weeks. determined insulin levels blood plasma biochemically analyzed Glut-4 citrate synthase M. gastrocnemius muscle tissue using Western blotting. The research results show that daily has different effects age groups In young-age animals, more pronounced weight. At week 12, young obese had 17% decrease Body did not change old mice. Moreover, at weeks 14 16, was (by 17%) compared 6%) (p < 0.05). older it influences rate uptake. 60 min, exercised decreased 14.46 mmol/L, while concentration non-exercised group remained 17 mmol/L. By 120 subjected exercise, approached initial value (6.92 mmol/L) amounted 8.35 group, this difference 45%. depend time day. greater observed when performing shift training or during animals passive (light phase). mice, light phase increasing content (84.3 ± 11.3%, p 0.05 control group-59.3 7.8%). aged caused an increase level (71.3 4.1%, group-56.4 10,9%). lower CS noticed all comparison It should also be noted we increased especially training. subgroup (135.8 7.0%) higher than dark (113.3 7.7%) = 0.0006). chow-fed high-fat-fed group. chow diet (58.2 5.0%) 38% HFD (94.9 8.8%).

Language: Английский

Citations

3
Role of Myokines and prospects for their role in Diabetes Mellitus Therapy DOI

Kharissova Nuriya,

Mindubaуeva Farida,

RK Sharma

et al.

Research Journal of Pharmacy and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 5119 - 5131

Published: Oct. 22, 2024

In the last decade, attention of researchers has been drawn to ability skeletal muscles produce biologically active substances (myokines). To date, several hundred myokines have identified in muscle secretome. Myokines autocrine and paracrine effects. They their own receptors various tissues organs. At certain concentrations, a systemic effect on organs, provide metabolic interaction between them huge range physiological However, biological activity many these mechanism action are either not yet characterized or poorly understood. Modern research is aimed at developing drugs that block myokine signaling pathways studying possibilities use treatment neuromuscular diseases, obesity, type 2 diabetes mellitus, orthopedic pathology, as well decrease mass strength. Type mellitus (T2DM) socially significant disease. Currently, there no effective therapy completely eradicate/cure its associated complications. It now necessary consider more detail molecular targets for each pharmacological drug. There need create new anti-diabetic future based myokines, knowing target cells, but also best possible combination strategies using available beneficial effects physical exercise prevention T2DM. A few studies mice humans shown increases levels numerous blood plasma, leading process transcription accelerating processes with increased load tissue. suggested secretion depends degree training; intensity duration athlete’s anatomical structure; sport which athlete plays. Further scientific will key understanding (proteins) body organs/systems tissues, undoubtedly contribute success doctors field practical healthcare correction pathological disorders, including mellitus.

Language: Английский

Citations

0