FUNDC1/USP15/Drp1 ameliorated TNF-α–induced pulmonary artery endothelial cell proliferation by regulating mitochondrial dynamics DOI

Chong Xu,

Bin Wang, Mei Li

et al.

Cellular Signalling, Journal Year: 2023, Volume and Issue: 113, P. 110939 - 110939

Published: Oct. 21, 2023

Language: Английский

Epigenomic signature of major congenital heart defects in newborns with Down syndrome DOI Creative Commons
Julia S. Mouat, Shaobo Li, Swe Swe Myint

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 5, 2023

Congenital heart defects

Language: Английский

Citations

2
Inhibition of Cyp1a Protects Mice against Anthracycline Cardiomyopathy DOI Open Access
Jing Liu, Casie Curtin, Rahul K. Lall

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 11, 2024

ABSTRACT Background Anthracyclines such as doxorubicin (Dox) are highly effective anti-tumor agents, but their use is limited by dose-dependent cardiomyopathy and heart failure. Our laboratory previously reported that induction of cytochrome P450 family 1 (Cyp1) enzymes contributes to acute Dox cardiotoxicity in zebrafish mice, potent Cyp1 inhibitors prevent cardiotoxicity. However, the role chronic cardiomyopathy, well mechanisms underlying cardioprotection associated with inhibition, have not been fully elucidated. Methods The pathway was evaluated using a small molecule inhibitor wild-type (WT) or Cyp1-null mice ( Cyp1a1/1a2 -/- , Cyp1b1 Cyp1a1/1a2/1b1 ). Low-dose administered serial intraperitoneal intravenous injections, respectively. Expression isoforms measured RT-qPCR, myocardial tissue isolated from left ventricle for RNA sequencing. Cardiac function transthoracic echocardiography. Results In WT treatment decrease Cyp1a2 increase expression liver. Co-treatment novel YW-130 protected against cardiac dysfunction compared alone. were mice. Male, female, had increased following sequencing showed upregulation Fundc1 downregulation Ccl21c treated Dox, implicating changes mitophagy chemokine-mediated inflammation possible Cyp1a-mediated cardioprotection. Conclusions Taken together, this study highlights potential therapeutic value Cyp1a inhibition mitigating anthracycline cardiomyopathy.

Language: Английский

Citations

0
An updated outlook on autophagy mechanism and how it supports acute myeloid leukemia maintenance DOI

Brunno Gilberto Santos de Macedo,

Manuela Albuquerque de Melo, Diego A. Pereira‐Martins

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(6), P. 189214 - 189214

Published: Nov. 1, 2024

Language: Английский

Citations

0
Ubiquitin-independent mitophagy: mechanisms and pathophysiological functions DOI
Chengyuan Tang, Zheng Dong

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 25 - 41

Published: Nov. 29, 2024

Language: Английский

Citations

0
FUNDC1/USP15/Drp1 ameliorated TNF-α–induced pulmonary artery endothelial cell proliferation by regulating mitochondrial dynamics DOI

Chong Xu,

Bin Wang, Mei Li

et al.

Cellular Signalling, Journal Year: 2023, Volume and Issue: 113, P. 110939 - 110939

Published: Oct. 21, 2023

Language: Английский

Citations

1