Real-time Quantification of in vivo cerebrospinal fluid velocity using fMRI inflow effect DOI Creative Commons
Tyler C. Diorio, Vidhya Vijayakrishnan Nair, Neal Patel

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 16, 2023

Abstract In vivo estimation of cerebrospinal fluid (CSF) velocity is crucial for understanding the glymphatic system and its potential role in neurodegenerative disorders such as Alzheimer’s disease Parkinson’s disease. Current cardiac or respiratory gated approaches, 4D flow MRI, cannot capture CSF movement real time due to limited temporal resolution addition deteriorate accuracy at low velocities. Other techniques like real-time PC-MRI time-spatial labeling inversion pulse are not by averaging but have availability even research settings. This study aims quantify inflow effect dynamic motion on functional magnetic resonance imaging (fMRI) , measurement velocity. We considered linear nonlinear models waveforms empirically fit them fMRI data from a controlled experiment. To assess utility this methodology human data, velocities were computed acquired eight healthy volunteers. Breath holding regimens used amplify oscillations. Our experimental revealed that nonlinearly related effect-mediated signal increase well estimated using an extension previous framework. Using relationship, we recovered signal, demonstrating our approach estimating brain. novel method could serve alternative quantifying slow time, ventricular system, thereby providing valuable insights into system’s function implications neurological disorders.

Language: Английский

Obesity and Dyslipidemia: A Review of Current Evidence DOI
Jelena Vekić, Aleksandra Stefanović, Aleksandra Zeljković

et al.

Current Obesity Reports, Journal Year: 2023, Volume and Issue: 12(3), P. 207 - 222

Published: July 6, 2023

Language: Английский

Citations

62
The emerging role of ferroptosis in female reproductive disorders DOI Creative Commons
Min Liu, WU Ke-ming,

Yeke Wu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 166, P. 115415 - 115415

Published: Sept. 4, 2023

Iron, as an essential trace element for the organism, is vital maintaining organism's health. Excessive iron can promote reactive oxygen species (ROS) accumulation, thus damaging cells and tissues. Ferroptosis a novel form of programmed cell death distinguished by overload lipid peroxidation, which unique from autophagy, apoptosis necrosis, more studies are focusing on ferroptosis. Recent evidence suggests that ferroptosis associated with development female reproductive disorders (FRDs), including polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI), endometriosis (EMs), cancer (OC), preeclampsia (PE) spontaneous abortion (SA). Pathways genes may participate in processes regulate granulosa proliferation secretion, oocyte development, reserve function, early embryonic placental oxidative stress. However, its exact mechanism has not been fully revealed. Therefore, our review systematically elaborates occurrence research progress FRDs, view to providing literature references clinical targeting -related pathways regulatory factors management FRDs.

Language: Английский

Citations

45
Dissecting the Roles of Lipids in Preeclampsia DOI Creative Commons
Yang Yu, Yixiao Wang, Yan Lv

et al.

Metabolites, Journal Year: 2022, Volume and Issue: 12(7), P. 590 - 590

Published: June 24, 2022

Preeclampsia is a multisystem pregnancy disorder that characterized by different degrees of placental malperfusion, with release antiangiogenic factors into the circulation, leading to maternal vascular endothelial injury and high blood pressure. As major cause perinatal mortality morbidity worldwide, once preeclampsia has been diagnosed, there are no curative treatments except for delivery. Lipids serve as ubiquitous multifunctional metabolites integral essential many diverse functions on both cellular organismal level. Lipid metabolic abnormalities have emerged potential risk development progression preeclampsia. This review comprehensively examines decades discovery illuminate roles lipids dysregulation in levels various lipid classes In addition, summarized further understand pathogenic mechanisms Overall, highlights promising pathophysiology lipid-targeting therapeutic strategies

Language: Английский

Citations

20
Maternal Serum Metabolomics in Mid-Pregnancy Identifies Lipid Pathways as a Key Link to Offspring Obesity in Early Childhood DOI Open Access
Ellen C. Francis, Katerina Kechris, Randi K. Johnson

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7620 - 7620

Published: July 11, 2024

Maternal metabolism during pregnancy shapes offspring health via in utero programming. In the Healthy Start study, we identified five subgroups of pregnant women based on conventional metabolic biomarkers: Reference (n = 360); High HDL-C 289); Dyslipidemic–High TG 149); FFA 180); Insulin Resistant (IR)–Hyperglycemic 87). These not only captured heterogeneity among participants but were also associated with obesity early childhood, even without or diabetes. Here, utilize metabolomics data to enrich characterization and identify key compounds driving between-group differences. We analyzed fasting blood samples from 1065 at 18 gestational weeks using untargeted metabolomics. used weighted gene correlation network analysis (WGCNA) derive a global subgroup characterized distinct metabolite modules representative different metabolomic profiles. mummichog algorithm for pathway enrichment that differed across subgroups. Eight representing pathways such as carnitine–acylcarnitine translocase system, fatty acid biosynthesis activation, glycerophospholipid identified. A module included 189 related DHA peroxidation, oxidative stress, sex hormone was elevated Resistant–Hyperglycemic vs. subgroup. This positively correlated total cholesterol (R:0.10; p-value < 0.0001) free acids (R:0.07; 0.05). Oxidative stress inflammatory may underlie insulin resistance pregnancy, below clinical diabetes thresholds. findings highlight potential therapeutic targets strategies risk stratification reveal mechanisms underlying developmental origins disease risk.

Language: Английский

Citations

4
Advanced multi-modal mass spectrometry imaging reveals functional differences of placental villous compartments at microscale resolution DOI Creative Commons
Marija Veličković, Leena Kadam, Joonhoon Kim

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 28, 2025

Language: Английский

Citations

0
Metabolic disorder of nutrients—an emerging field in the pathogenesis of preeclampsia DOI Creative Commons

Shuyue Li,

Jie Zhu, Ying Zhao

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 7, 2025

It is well acknowledged that metabolic disorder binds closely with preeclampsia, though some of the causal relationships are still ambiguous. This review systematically summarizes characteristics carbohydrates, lipids, amino acids, and glycans in highlighting their roles oxidative stress, trophoblast autophagy, inflammatory response, vascular tone regulation. Key findings include upregulated glycolysis impaired mitochondrial function contributing to ATP deficiency, dysregulated lipid metabolism exacerbating stress dysfunction, acid imbalances disrupting immune responses redox homeostasis. Emerging therapies, such as metformin pravastatin, demonstrate potential targeting these pathways for prevention treatment. Here, we reviewed thoroughly related literature a view delineating association nutrient so could explore promising therapeutic approach.

Language: Английский

Citations

0
Chewing the fat: How lipidomics is changing our understanding of human health and disease in 2022 DOI Open Access
Caroline Géhin, Stephen J. Fowler, Drupad K. Trivedi

et al.

Analytical Science Advances, Journal Year: 2023, Volume and Issue: 4(3-4), P. 104 - 131

Published: May 1, 2023

Abstract Lipids are biological molecules that play vital roles in all living organisms. They perform many cellular functions, such as 1) forming and subcellular membranes, 2) storing using energy, 3) serving chemical messengers during intra‐ inter‐cellular signal transduction. The large‐scale study of the pathways networks lipids systems is called “lipidomics” one fastest‐growing omics technologies last two decades. With state‐of‐the‐art mass spectrometry instrumentation sophisticated data handling, clinical studies show how human lipid composition changes health disease, thereby making it a valuable medium to collect for applications, disease diagnostics, therapeutic decision‐making, drug development. This review gives comprehensive overview current workflows used research, from sample collection preparation interpretations. followed by an appraisal applications 2022 perspective on exciting future lipidomics.

Language: Английский

Citations

10
The overview of lactylation in the placenta of preeclampsia DOI

Qiaoli Feng,

Ping Yang,

Jinli Lyu

et al.

Placenta, Journal Year: 2025, Volume and Issue: 160, P. 135 - 143

Published: Jan. 5, 2025

Language: Английский

Citations

0
A Lipidomic Study to Identify the Serum Lipid Markers for Obstetric Antiphospholipid Syndrome DOI

Zhaoer Yu,

Yixiao Wang, Lili Fan

et al.

Journal of Proteome Research, Journal Year: 2025, Volume and Issue: 24(2), P. 491 - 498

Published: Jan. 6, 2025

This study used untargeted lipidomics to analyze the characteristics of lipid metabolism in serum women with antiphospholipid syndrome. Twenty female patients APS and 20 healthy controls were recruited this study. Untargeted liquid chromatography-tandem mass spectrometry was profile lipids. Correlation analyses performed on significant differential Least absolute shrinkage selection operator (LASSO) regression binary logistic find possible biomarkers. Finally, receiver operating characteristic (ROC) curve analysis evaluate diagnostic performance The significantly different from that controls. After statistical database matching, 12 lipids found be between two groups, most obvious differences being triacylglycerols phosphatidylcholines. LASSO models revealed PC (17:0/22:6) ACar (17:3) may biomarkers APS. ROC shows combined gave an area under 0.865 for diagnosis could as

Language: Английский

Citations

0
FTIR microscopic study on biomolecular alterations in placental tissues of intrahepatic cholestasis of pregnancy DOI
Wenjie Yu, Weilin Wang, Xiaojie Zhou

et al.

Analytical Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder that typically leads to severe outcomes. Although genetic, endocrine, and environmental factors are involved in the etiology ICP, role metabolic disorders remains unclear. Here we report an examination biomolecular alterations placental tissues women with ICP healthy pregnant at molecular level. By integrating FTIR microspectroscopy advanced multivariate statistical analysis semiquantitative methods, including PCA, OPLS-DA peak area ratio calculations, were revealed. Specifically, lipid conformations increased acyl chain unsaturation group associated bile acids participating regulation metabolism. Additionally, reduction relative α-helix content proteins compared β-sheet structures was changes apoptosis-related proteins. Furthermore, nucleic acid lipids elevated group. Our study underscores potential as powerful tool for investigating underlying biochemical mechanisms related ICP.

Language: Английский

Citations

0