Mutual coupling of neurons in the circadian master clock: what we can learn from fruit flies

Neurobiology of Sleep and Circadian Rhythms, Journal Year: 2025, Volume and Issue: 18, P. 100112 - 100112

Published: Jan. 18, 2025

Circadian master clocks in the brain consist of multiple neurons that are organized into populations with different morphology, physiology, and neuromessenger content presumably functions. In most animals, these distributed bilaterally, located close proximity to visual system, synchronized by eyes light-dark cycles environment. mammals cockroaches, each two consists a core region receives information from shell which output projections originate, whereas flies several other insects, lateral dorsal regions. all cases, morning evening clock seem exist, communication between them neurons, as well connection across hemispheres, is prerequisite for normal rhythmic function. Phenomena such rhythm splitting, internal desynchronization caused "decoupling" hemispheres or decoupling certain within one hemisphere. Since contain relatively few characterized at individual level, fly particularly suited study neurons. Here, we review organization bilateral brain, focus on synaptic paracrine connections comparison insects mammals.

Language: Английский

Integrity of the circadian clock determines regularity of high-frequency and diurnal LFP rhythms within and between brain areas

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract Circadian clocks control most physiological processes of many species. We specifically wanted to investigate the influence environmental and endogenous rhythms their interplay on electrophysiological dynamics neuronal populations. Therefore, we measured local field potential (LFP) time series in wild-type Cryptochrome 1 2 deficient ( Cry1/2 −/− ) mice suprachiasmatic nucleus accumbens under regular light conditions constant darkness. Using refined descriptive statistical analyses, systematically profiled LFP activity. show that both strongly rhythmicity signals frequency components, but also shape patterns much smaller scales, as activity is significantly less at each more synchronous within between brain areas than mice. These results functional circadian are integral for non-circadian coordination ensemble dynamics.

Language: Английский