Biophysical Chemistry,
Journal Year:
2024,
Volume and Issue:
316, P. 107351 - 107351
Published: Nov. 14, 2024
Humans
exposed
to
altitude
hypoxia
experience
dysfunctions
of
the
urinary
system.
As
a
non-invasive,
easily
manageable
and
informative
biological
sample,
urine
represents
relevant
matrix
for
detecting
clinical
impairments
system,
as
well
alterations
other
systems
extracellular
vesicles
(EVs)
biology
during
high-altitude
expeditions.
Nevertheless,
gaps
exist
in
comprehensive
assessment
dysfunction,
molecular
burden
EVs
due
acute
exposure.
This
study
aimed
find
biophysical
biochemical
signature
hypoxia-induced
changes
function,
putatively
accompanied
by
an
oxinflammatory
burden.
Urine
samples
15
participants
were
sampled
at
low
Alpine
project
(7
women
8
men,
aged
24-to-63
years
with
BMI
17.93-to-30.76
kg/m
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 523 - 523
Published: Feb. 19, 2025
Autosomal
dominant
polycystic
kidney
disease
(ADPKD)
is
a
prevalent
hereditary
disorder
characterized
by
distinct
phenotypic
variability
that
has
posed
challenges
for
advancing
in-depth
research.
Recent
advancements
in
organoid
construction
technologies
have
enabled
researchers
to
simulate
development
and
create
simplified
vitro
experimental
environments,
allowing
more
direct
observation
of
how
genetic
mutations
drive
pathological
phenotypes
disrupt
physiological
functions.
Emerging
technologies,
such
as
microfluidic
bioreactor
culture
systems
single-cell
transcriptomics,
further
supported
the
complex
ADPKD
organoids,
offering
robust
models
exploring
mechanisms
facilitating
drug
discovery.
Nevertheless,
significant
remain
constructing
accurate
models.
This
review
will
summarize
recent
advances
construction,
focusing
on
limitations
current
techniques
critical
issues
need
be
addressed
future
breakthroughs.
New
Noteworthy:
presents
particularly
iPSC-derived
models,
new
insights
into
It
focuses
limited
vascularization
maturity,
proposing
potential
solutions
through
emerging
technologies.
The
ongoing
optimization
expected
enhance
understanding
breakthroughs
targeted
therapy
development.
Transplant International,
Journal Year:
2024,
Volume and Issue:
37
Published: Feb. 13, 2024
An
increasing
body
of
randomized
controlled
trials
suggests
the
safety
engaging
in
moderate
to
vigorous
intensity
exercise
training
following
solid
organ
transplantation.
Fueled
by
emerging
sport
events
designed
for
transplant
recipients
and
ever-growing
research
highlighting
diverse
health
benefits
physical
activity,
are
now
increasingly
participating
strenuous
occasionally
competitive
endeavors
that
largely
surpass
those
evaluated
settings.
This
viewpoint
article
adopts
a
cautionary
stance
counterbalance
prevalent
one-sided
optimistic
perspective
regarding
posttransplant
activity.
While
discussing
methodological
limitations,
we
explore
plausible
adverse
impacts
on
cardiovascular,
immunological,
musculoskeletal
systems.
We
also
examine
physiological
consequences
exercising
heat,
at
high
altitude,
areas
with
air
pollution.
Risks
associated
employing
performance-enhancing
strategies
conceivable
psychological
implications
activity
as
tribute
‘gift
life’
discussed.
With
deliberate
focus
potential
outcomes
this
aims
restore
balanced
dialogue
our
comprehension
both
beneficial
potentially
detrimental
ultimately
underscores
imperative
well-informed
decision-making
tailored
regimens
realm
care.
Molecular Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
20(9), P. 4373 - 4386
Published: Aug. 14, 2023
Ischemia
or
hypoxia
can
lead
to
pathological
changes
in
the
metabolism
and
function
of
tissues
then
various
diseases.
Timely
effective
blood
resuscitation
improvement
is
very
important
for
treatment
However,
there
a
need
develop
stable,
nontoxic,
immunologically
inert
oxygen
carriers
due
limitations
such
as
shortages,
different
types,
risk
transmitting
infections.
With
development
technologies,
based
on
hemoglobin
perfluorocarbon
have
been
widely
studied
recent
years.
This
paper
reviews
application
carriers.
The
design
was
analyzed,
their
substitutes
hypoxic
diseases
discussed.
Finally,
characteristics
future
research
ideal
were
prospected
provide
reference
follow-up
research.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: March 31, 2024
Abstract
The
study
presented
here
aims
at
assessing
the
effects
of
hypobaric
hypoxia
on
RAAS
pathway
and
its
components
along
with
mitigation
anomalies
quercetin
prophylaxis.
One
hour
prior
to
exposure,
male
SD
rats
were
orally
supplemented
(50
mg/kg
BW)
acetazolamide
exposed
them
25,000
ft.
(7,620
m)
in
a
simulated
environmental
chamber
for
12
h
25
±
2
°C.
Different
biochemical
parameters
like
renin
activity,
aldosterone,
angiotensin
I,
ACE
determined
plasma.
As
conventional
response
low
oxygen
conditions,
oxidative
stress
(ROS
MDA)
elevated
suppressed
antioxidant
system
(GPx
catalase)
plasma
rats.
Quercetin
prophylaxis
significantly
down
regulated
induced
by
reducing
ROS
&
MDA
levels
efficient
enhancement
antioxidants
Catalase).
Further,
mediated
regulation
proves
outstanding
efficacy
repudiating
altercations
cascade
due
hypoxia.
Furthermore,
differential
protein
expression
HIF-1α,
NFκB,
IL-18
endothelin-1
analyzed
western
blotting
approves
outcomes
showed
that
aids
reduction
inflammation
under
Studies
conducted
Surface
Plasmon
Resonance
demonstrated
binding
among
indicates
this
flavonoid
might
regulate
via
2.
Henceforth,
promotes
better
adaptability
hypoxic
conditions
modulating
pathway.
Frontiers in Public Health,
Journal Year:
2025,
Volume and Issue:
13
Published: March 27, 2025
Background
Exposure
to
high
altitude
(HA)
has
been
shown
significantly
increase
the
risk
of
venous
thromboembolism
(VTE).
However,
clinical
characteristics
VTE
at
extremely
altitudes
remain
poorly
understood.
In
this
single-center
retrospective
study,
we
aimed
compare
and
prognoses
pulmonary
embolism
(PE)
patients
with
those
low
(LA).
Methods
This
analysis
focused
on
PE
treated
General
Hospital
Xinjiang
Military
Command
between
November
1,
2019,
2022.
The
high-altitude
group
(HA-Group)
consisted
who
sought
medical
treatment
after
they
had
fallen
ill
into
plateau
area,
low-altitude
(LA-Group)
local
residents.
Results
We
identified
a
total
17
in
HA-Group
62
LA-Group.
average
was
5,041
±
85.34
m,
802.1
11.10
m
LA-Group
(
p
<
0.0001).
Hematological
indicators,
including
red
blood
cells,
lymphocytes,
platelet
counts,
hemoglobin,
PT,
APTT,
INR
uric
acid,
were
higher
than
Kaplan–Meier
curve
demonstrated
that
time
complete
resolution
thrombosis
shorter
(log-rank
=
0.033).
Conclusion
study
revealed
altitudes.
High-altitude
exposure
may
susceptibility
young
people
PE,
abnormal
serum
acid
metabolism
be
potential
factor
for
areas.
The
renal
system
is
a
significant
organ
vulnerable
to
stress
due
its
physiological
function
of
toxin
elimination.
Exposure
wide
array
xenobiotics
in
humans
causes
deleterious
effects
the
kidneys.
In
present
study,
we
observed
toxic
effect
coexposure
bisphenol
A
and
acetaminophen
on
mitochondria
Wistar
rats
amelioration
by
melatonin.
animals
were
grouped
treated
for
4
weeks
as
follows:
(I)
control;
(II)
melatonin;
(III)
A;
(IV)
acetaminophen;
(V)
(VI)
A,
Coadministration
exposure
significantly
impaired
function,
elevating
creatinine
(2.28
mg/dL),
BUN
(65.42
mg/dL)
uric
acid
(6.11
while
increasing
oxidative
inflammatory
markers
(CAT:
3.85-μmol
H2O2/min/mg
protein,
GPx:
189.57-nmol
NADPH/min/mg
GR:
96.62-nmol
MnSOD:
107.24-nmol
(-)
epinephrine/min/mg
IL-6:
1750
pg/mL,
TNFα:
1677
pg/mL).
Melatonin
coadministration
improved
(creatinine:
1.60
mg/dL,
BUN:
45.59
acid:
4.61
partially
restored
antioxidant
defences
5.74-μmol
422.74-nmol
136.91-nmol
nmol
epinephrine
prevented
from
oxidation/min/mg
900
These
findings
suggest
that
melatonin
mitigates
acetaminophen-induced
damage
enhancing
reducing
inflammation.
IGI Global eBooks,
Journal Year:
2025,
Volume and Issue:
unknown, P. 509 - 522
Published: March 28, 2025
Patients
with
chronic
illnesses
who
embark
on
long-haul
travel
face
formidable
challenges
due
to
their
compromised
immune
systems,
making
them
more
susceptible
infections
and
associated
complications
such
as
hospitalization,
intensive
care
admission,
mortality.
This
chapter
analyzes
the
diverse
barriers—interpersonal,
intrapersonal,
economic,
structural,
attitudinal—these
individuals
encounter
when
planning
undertaking
journeys.
It
also
recognizes
intricacies
involved
in
offers
tailored
considerations
for
acquired
disabilities.
Accounts
from
firsthand
travellers
shed
light
specific
encountered
by
those
living
conditions
heart
disease,
diabetes,
asthma,
arthritis.
These
insights
are
invaluable
shaping
a
comprehensive
approach
health
services,
incorporating
perspectives
healthcare
professionals
practical
strategies
long-distance
while
managing
illnesses.
Medicine,
Journal Year:
2024,
Volume and Issue:
103(12), P. e37509 - e37509
Published: March 22, 2024
Xining
is
located
at
the
eastern
edge
of
Qinghai-Tibet
Plateau,
with
an
average
altitude
>7000
feet
(>2000
m).
Nalbuphine
a
kappa-opioid
receptor
agonist
that
can
provide
analgesia
fewer
side
effects
than
other
opioid
analgesics.
This
study
aimed
to
evaluate
pain
control,
effects,
and
neonatal
outcomes
from
combining
nalbuphine
sufentanil
ropivacaine
in
600
women
during
epidural
anesthesia
while
giving
birth
high
Xining,
China.
A
total
parturients
receiving
labor
were
randomly
divided
into
2
groups,
each
group
300
parturients.
The
received
nalbuphine,
sufentanil,
ropivacain,
control
only
ropivacain.
analgesic
effect
was
evaluated
through
Visual
Analogue
Scale
scores.
Neonatal
mainly
Apgar
Scores.
Compared
group,
showed
lower
scores
all
time
points
after
(
P
<
.05).
In
comparison
incidence
rates
fever
delivery,
24-hour
postpartum
bleeding,
pruritus
However,
between
there
no
statistically
significant
differences
remaining
maternal
infant
>
Moreover,
adverse
on
observed.
findings
this
support
previous
studies
provided
safe
without
for
mother
infant,
both
safety
efficacy
when
used
altitude.
