Enhanced memory despite severe sleep loss in Drosophila insomniac mutants

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(3), P. e3003076 - e3003076

Published: March 20, 2025

Sleep is crucial for cognitive functions and life span across species. While sleep homeostasis processes are linked through cellular synaptic plasticity, the signaling pathways connecting them remain unclear. Here, we show that Drosophila insomniac ( inc ) short mutants, which lack an adaptor protein autism-associated Cullin-3 ubiquitin ligase, exhibited enhanced Pavlovian aversive olfactory learning memory, unlike other mutants with normal or reduced memory. Through a genetic modifier screen, found mild reduction of Protein Kinase A (PKA) specifically rescued longevity phenotypes mutants. However, this further increased their excessive memory mushroom body overgrowth. Since displayed higher PKA signaling, propose loss-of-function suppresses via activity, also constrains Our data identify cascade balancing functions, provide plausible explanation suggesting hyperfunction can provoke deficits.

Language: Английский

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Differential amino acid transporter expression in adult

PubMed, Journal Year: 2024, Volume and Issue: 2024

Published: Jan. 1, 2024

Organismal macronutrient intake modulates organ and tissue function. Dietary amino acids play essential roles in metabolic processes that support normal growth, repair, For example,

Language: Английский

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An integrative sensor of body states: how the mushroom body modulates behavior depending on physiological context

Learning & Memory, Journal Year: 2024, Volume and Issue: 31(5), P. a053918 - a053918

Published: May 1, 2024

The brain constantly compares past and present experiences to predict the future, thereby enabling instantaneous future behavioral adjustments. Integration of external information with animal's current internal needs state represents a key challenge nervous system. Recent advancements in dissecting function Drosophila mushroom body (MB) at single-cell level have uncovered its three-layered logic parallel systems conveying positive negative values during associative learning. This review explores lesser-known role MB detecting integrating states such as hunger, thirst, sleep, ultimately modulating motivation sensory-driven decisions based on physiological fly. State-dependent signals predominantly affect activity modulatory input neurons (dopaminergic, serotoninergic, octopaminergic), but also induce plastic changes directly intrinsic output neurons. Thus, emerges tightly regulated relay station insect brain, orchestrating neuroadaptations due leading short- long-lasting behavior. While these adaptations are crucial ensure fitness survival, recent findings underscore how circuit motifs may reflect fundamental design principles that contribute maladaptive behaviors addiction or depression-like symptoms.

Language: Английский

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Intermittent Vibration Induces Sleep via an Allatostatin A‐GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

While animals across species typically experience suppressed consciousness and an increased arousal threshold during sleep, the responsiveness to specific sensory inputs persists. Previous studies have demonstrated that rhythmic continuous vibration can enhance sleep in both humans. However, neural circuits underlying vibration-induced (VIS) its potential therapeutic benefits on neuropathological processes disease models remain unclear. Here, it is shown intermittent vibration, such as cycles of 30 s followed by off, more effective inducing compared vibration. A clear evidence further provided allatostatin (AstA)-GABA signaling mediates short-term (iVIS) inhibiting octopaminergic neurons through activating GABA

Language: Английский

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Sleep-like State in Pond Snails Leads to Enhanced Memory Formation

Biology, Journal Year: 2024, Volume and Issue: 13(5), P. 336 - 336

Published: May 11, 2024

To test the hypothesis that a sleep-like quiescent state enhances memory consolidation in pond snail Lymnaea stagnalis, we interposed period which snails experienced either quiescent, sleeping or an active, non-sleeping following escape behavior suppression learning (EBSL). During EBSL training, number of escapes made by from container was significantly suppressed using external aversive stimulus (punishment). After were divided into two groups. One group allowed to move freely and experience for 3 h distilled water. The other stimulated with sucrose solution every 10 min keep them active (i.e., non-sleeping). In test, state, whereas not observed kept active. Additionally, latency first shorter than those state. Together, these data are consistent L. stagnalis.

Language: Английский

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Cognitive hyperplasticity drives insomnia

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Abstract Sleep is vital for maintenance of cognitive functions and lifespan across the animal kingdom. Here, we report our surprising findings that insomniac ( inc ) Drosophila short sleep mutants, which lack a crucial adaptor protein autism-associated Cullin-3 ubiquitin ligase, exhibited excessive olfactory memory. Through genetic modifier screen, find mild attenuation Protein Kinase A (PKA) signaling specifically rescued longevity phenotypes mutants. Surprisingly, this PKA reduction further boosted memory in coupled with exaggerated mushroom body overgrowth phenotypes. We propose an intrinsic hyperplasticity scenario genuine to mutants enhances functions. Elevating seems serve as checkpoint allows constrain these animals, albeit at sacrifice longevity. Our data offer mechanistic explanation deficits challenges traditional views on relation between memory, suggest behavioral hyperplasticity, e.g., prominent autistic patients, can provoke deficits.

Language: Английский

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