14-Week exercise training modifies the DNA methylation levels at gene sites in non-Alzheimer's disease women aged 50 to 70 years DOI Creative Commons
Guilherme da Silva Rodrigues, Natália Yumi Noronha, Isabella Harumi Yonehara Noma

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 186, P. 112362 - 112362

Published: Jan. 21, 2024

Exercise training emerges as a key strategy in lifestyle modification, capable of reducing the risk developing Alzheimer's disease (AD) due to factors such age, family history, genetics and low level education associated with AD. We aim analyze effect 14-week combined exercise (CT) on methylation genes AD non-alzheimer's women. CT sessions lasted 60 min, occurring three times week for 14 weeks. Forty non-Alzheimer's women aged 50 70 years (60.7 ± 4.1 years) mean height 1.6 0.1 m, weight 73.12 9.0 kg body mass index 29.69 3.5 kg/m2, underwent two physical assessments: pre post DNA assays utilized EPIC Infinium Methylation BeadChip from Illumina. observed that weeks led reductions systolic (p = 0.001) diastolic 0.017) blood pressure improved motor skills post-intervention. Among 25 linked AD, induced differentially methylated sites 12 genes, predominantly showing hypomethylated (negative β values). Interestingly, despite sites, some exhibited hypermethylated (positive values), ABCA7, BDNF, WWOX. A regimen was adequate induce differential CE-related healthy older women, alongside improvements pressure. In conclusion, this study suggest can be improve fitness individuals, especially able alterations related development It is important highlight should act protective factor adults.

Language: Английский

14-Week exercise training modifies the DNA methylation levels at gene sites in non-Alzheimer's disease women aged 50 to 70 years DOI Creative Commons
Guilherme da Silva Rodrigues, Natália Yumi Noronha, Isabella Harumi Yonehara Noma

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 186, P. 112362 - 112362

Published: Jan. 21, 2024

Exercise training emerges as a key strategy in lifestyle modification, capable of reducing the risk developing Alzheimer's disease (AD) due to factors such age, family history, genetics and low level education associated with AD. We aim analyze effect 14-week combined exercise (CT) on methylation genes AD non-alzheimer's women. CT sessions lasted 60 min, occurring three times week for 14 weeks. Forty non-Alzheimer's women aged 50 70 years (60.7 ± 4.1 years) mean height 1.6 0.1 m, weight 73.12 9.0 kg body mass index 29.69 3.5 kg/m2, underwent two physical assessments: pre post DNA assays utilized EPIC Infinium Methylation BeadChip from Illumina. observed that weeks led reductions systolic (p = 0.001) diastolic 0.017) blood pressure improved motor skills post-intervention. Among 25 linked AD, induced differentially methylated sites 12 genes, predominantly showing hypomethylated (negative β values). Interestingly, despite sites, some exhibited hypermethylated (positive values), ABCA7, BDNF, WWOX. A regimen was adequate induce differential CE-related healthy older women, alongside improvements pressure. In conclusion, this study suggest can be improve fitness individuals, especially able alterations related development It is important highlight should act protective factor adults.

Language: Английский

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