Implication of iron overload in COVID-19 pathogenesis and long COVID: a mechanistic review DOI
Bijita Bhowmick, Anirban Roy, Avipsha Sarkar

et al.

Future Virology, Journal Year: 2024, Volume and Issue: 19(14-15), P. 525 - 538

Published: Oct. 12, 2024

COVID-19 causes cytokine storm which results in altered iron homeostasis within the system. The negative consequences of this include poor metabolism, ROS-induced oxidative damage, ferroptosis, and increased severity along with illnesses like anemia, thalassemia, diabetes, cancer, neurological disorders, long COVID. Therefore, managing overload natural or synthetic chelators alternative therapeutics can help to reduce COVID-19. This review analyzes intricate molecular mechanism dynamics during SARS-CoV-2 infection disease progression patients related clinical consequences. Also, explores a comprehensive understanding reciprocal between their adverse effects, thereby facilitating development potential therapeutic interventions.

Language: Английский

Prevalence and risk factors of long COVID among maintenance hemodialysis patients post SARS‐CoV‐2 infection: A one‐year follow‐up study in China DOI
Xue Zhao, Lei Chen,

Linhui Huo

et al.

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(9)

Published: Sept. 1, 2024

Abstract Patients undergoing maintenance hemodialysis (MHD) are a high‐risk group susceptible to SARS‐CoV‐2 infection and long‐COVID syndrome appearance. However, there is limited unclear evidence for long COVID in MHD patients. We collected the general information, symptoms, signs laboratory indices of 366 patients infected with COVID‐19 conducted 12 months follow‐up series questionnaires. As result, 285 had COVID, most common symptoms were fatigue (84.69%) muscle weakness (72.45%). Mobility problem ( p < 0.001), anxiety/depression = 0.002) breathlessness 0.001) more prevalent than non‐long Persistent people likely report all domains problems EQ‐5D‐5L. Age, female, inadequate dialysis (Kt/V 1.2), coagulation abnormalities (d‐dimer > 1 mg/L) comorbidities risk factors development COVID. In addition these factors, elevated inflammatory markers (CRP 10 represent an extra factor persistence And 80% would resolve after year patients, which sixth month critical turning point. conclusion, 68% have has poor impact on their health status quality life. These deserve attention clinicians.

Language: Английский

Citations

0
Unveiling the hidden link: elevated platelets and T cell subsets in 5% of moderate COVID-19 patients 48 days post-onset DOI Creative Commons

Hui Jeong An,

Ting Li,

Lanting Yang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 19, 2024

Platelets are hyperactived during acute COVID-19, promoting clotting and modulating immune-cell responses. Immune thrombocytopenia in adults can manifest as an uncommon complication resulting from various viral infections or a rare adverse event associated with vaccination. However, their role convalescent COVID-19 patients remains underexplored. This study examines platelet dynamics early the pandemic, 48 days post-symptom onset, unvaccinated patients.

Language: Английский

Citations

0
Red Blood Cell Morphology Is Associated with Altered Hemorheological Properties and Fatigue in Patients with Long COVID DOI Creative Commons
Marijke Grau,

Alena Presche,

A. Krüger

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(11), P. 948 - 948

Published: Nov. 19, 2024

SARS-CoV-2 infection adversely affects rheological parameters, particularly red blood cell (RBC) aggregation and deformability, but whether these changes persist in patients suffering from Long-COVID (LC) are related to RBC morphology remain unknown.

Language: Английский

Citations

0
Postcovid syndrome in residents of North-West Russia: clinical, laboratory and neuropsychiatric consequences DOI Open Access

N. А. Belyakov,

В. В. Рассохин, E. V. Boeva

et al.

HIV Infection and Immunosuppressive Disorders, Journal Year: 2024, Volume and Issue: 16(3), P. 11 - 24

Published: Nov. 27, 2024

The aim. To analyze anamnestic data, clinical and laboratory parameters, psychoneurological manifestations in patients the post-COVID period. Materials methods . After initial survey of 1,200 respondents who had suffered from a new coronavirus infection (COVID-19), group 170 was identified based on presence complaints about state somatic mental health that have temporary relationship with SARS-CoV-2 disease. As part study, this underwent comprehensive examination an assessment general biochemical inflammatory markers blood coagulation system. All were examined by infectious disease specialist, neurologist, psychiatrist-narcologist medical psychologist. main socio-demographic data period, as well neurological psycho-emotional characteristics obtained 130 participants 2024, assessed. In order to study cognitive executive functions, state, following used: Montreal Cognitive Assessment (MoCA), Hospital Anxiety Depression Scale (HADS) SCL-90 Symptomatic Questionnaire. addition, each respondent asked determine severity psychopathological, neurological, symptoms using «Not bothered-Weakly-Moderately-Extremely» scale specially developed for which included up 38 symptoms. Results discussion majority sample women (80%). Over 2⁄3 working age, average age 38.2±11.3 years, 65.3% mild forms COVID-19. Repeated cases COVID-19 associated high risk saturation decrease ≤93% (p<0.01), while severe absence vaccination (p<0.05). Ferritin levels below 30 μg/L recorded 34.1% 9.15% men, may indicate deficiency iron stores body. Hypercholesterolemia noted 54.9% cases, total cholesterol 5.52±1.19mmol/L. number NCI (2 or more) is leukocytes, increase platelets blood, percentage monocytes, level protein, Neurological are characterized pronounced polymorphism, 15.3% having exhaustion superficial abdominal reflexes, 26.9% impairment, 7.7% significant decline functions. 49.5% showed signs anxiety, 29.4% depressive phenomena, expressed at subclinical level. distress caused sensations bodily dysfunction somatic, painful and/or neuromuscular nature characteristic, hypochondriacal tendencies separate respondents. Conclusion. Comparison results questionnaire in-depth disorders widespread among different groups, regardless Given mechanism direct indirect effects brain, it damage nervous system, including functions psychoemotional sphere, largely disorders. complexity versatility syndrome require involvement specialists various profiles patients, need develop protocols recommendations people syndrome.

Language: Английский

Citations

0
Implication of iron overload in COVID-19 pathogenesis and long COVID: a mechanistic review DOI
Bijita Bhowmick, Anirban Roy, Avipsha Sarkar

et al.

Future Virology, Journal Year: 2024, Volume and Issue: 19(14-15), P. 525 - 538

Published: Oct. 12, 2024

COVID-19 causes cytokine storm which results in altered iron homeostasis within the system. The negative consequences of this include poor metabolism, ROS-induced oxidative damage, ferroptosis, and increased severity along with illnesses like anemia, thalassemia, diabetes, cancer, neurological disorders, long COVID. Therefore, managing overload natural or synthetic chelators alternative therapeutics can help to reduce COVID-19. This review analyzes intricate molecular mechanism dynamics during SARS-CoV-2 infection disease progression patients related clinical consequences. Also, explores a comprehensive understanding reciprocal between their adverse effects, thereby facilitating development potential therapeutic interventions.

Language: Английский

Citations

0