Cannabinol (CBN) Influences the Ion Channels and Synaptic-Related Genes in NSC-34 Cell Line: A Transcriptomic Study DOI Creative Commons
Alessandra Trainito, Claudia Muscarà, Agnese Gugliandolo

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(18), P. 1573 - 1573

Published: Sept. 19, 2024

Neurological disorders such as Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and schizophrenia are associated with altered neuronal excitability, resulting from dysfunctions in the molecular architecture physiological regulation of ion channels synaptic transmission. Ion synapses regarded suitable therapeutic targets modern pharmacology. Cannabinoids have received great attention an original approach for their effects on human health due to ability modulate neurotransmitter release through interaction endocannabinoid system. In our study, we explored effect cannabinol (CBN) next-generation sequencing analysis NSC-34 cell physiology. Our findings revealed that CBN strongly influences ontologies related synapse activity at all doses tested. Specifically, genes coding calcium potassium voltage-gated channel subunits, glutamatergic GABAergic receptors (Cacna1b, Cacna1h, Cacng8, Kcnc3, Kcnd1, Kcnd2, Kcnj4, Grik5, Grik1, Slc17a7, Gabra5), were up-regulated. Conversely, involved into serotoninergic cholinergic pathways (Htr3a, Htr3b, Htr1b, Chrna3, Chrnb2, Chrnb4), down-regulated. These highlight influence expression influx

Language: Английский

Cannabinol (CBN) Influences the Ion Channels and Synaptic-Related Genes in NSC-34 Cell Line: A Transcriptomic Study DOI Creative Commons
Alessandra Trainito, Claudia Muscarà, Agnese Gugliandolo

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(18), P. 1573 - 1573

Published: Sept. 19, 2024

Neurological disorders such as Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and schizophrenia are associated with altered neuronal excitability, resulting from dysfunctions in the molecular architecture physiological regulation of ion channels synaptic transmission. Ion synapses regarded suitable therapeutic targets modern pharmacology. Cannabinoids have received great attention an original approach for their effects on human health due to ability modulate neurotransmitter release through interaction endocannabinoid system. In our study, we explored effect cannabinol (CBN) next-generation sequencing analysis NSC-34 cell physiology. Our findings revealed that CBN strongly influences ontologies related synapse activity at all doses tested. Specifically, genes coding calcium potassium voltage-gated channel subunits, glutamatergic GABAergic receptors (Cacna1b, Cacna1h, Cacng8, Kcnc3, Kcnd1, Kcnd2, Kcnj4, Grik5, Grik1, Slc17a7, Gabra5), were up-regulated. Conversely, involved into serotoninergic cholinergic pathways (Htr3a, Htr3b, Htr1b, Chrna3, Chrnb2, Chrnb4), down-regulated. These highlight influence expression influx

Language: Английский

Citations

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