Enhancing muscle and brain resilience: The role of prehabilitative exercise in mitigating disuse effects
The Journal of Physiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 6, 2025
Abstract
Short‐term
disuse
leads
to
rapid
declines
in
muscle
mass
and
strength.
These
are
driven
by
changes
at
all
levels
of
the
neuromuscular
system;
brain,
spinal
cord
skeletal
muscle.
In
addition
neural
input
from
central
peripheral
nervous
systems
muscle,
molecular
factors
originating
can
be
transported
system.
interactions
highlight
interconnected
nature
system
during
exercise
disuse,
form
basis
for
this
review.
Although
it
is
well
known
that
physical
activity
confers
a
myriad
health
benefits,
recent
interest
targeted
before
periods
or
immobility,
termed
prehabilitation,
has
emerged.
Clinical
studies
within
multiple
medical
specialities
suggest
positive
effects
prehabilitative
on
preserving
function,
reducing
adverse
outcomes
shortening
length
hospital
stay.
Yet,
available
few
heterogeneous,
underlying
protective
mechanisms
remain
elusive.
review,
we
examine
ramifications
across
explore
how
prehabilitation
may
counteract
these
effects.
We
summarize
into
three
primary
categories:
(1)
enhancing
pre‐disuse
capacity;
(2)
establishing
memory;
(3)
fostering
structural
adaptations
both
brain.
image
Language: Английский
Effects of Combined Transcriptome and Metabolome Analysis Training on Athletic Performance of 2-Year-Old Trot-Type Yili Horses
Genes,
Journal Year:
2025,
Volume and Issue:
16(2), P. 197 - 197
Published: Feb. 4, 2025
Training
is
essential
for
enhancing
equine
athletic
performance,
but
the
genetic
mechanisms
that
regulate
performance
are
unknown.
Therefore,
this
paper
aims
to
identify
candidate
genes
and
metabolic
pathways
effects
of
training
on
through
multi-omics
analyses.
The
experiment
selected
12
untrained
trot-type
Yili
horses,
which
underwent
a
12-week
professional
program.
Blood
samples
were
collected
at
rest
before
(BT)
after
(AT).
Based
their
race
whole
blood
serum
from
4
horses
chosen
transcriptomic
metabolomic
dramatically
improved
in
AT
period
compared
BT
(p
<
0.01)
period.
transcriptome
analysis
identified
total
57
differentially
expressed
genes,
significantly
enriched
related
circadian
entrainment,
steroid
hormone
biosynthesis,
chemokine
signaling,
cholinergic
synapses
0.05).
Additionally,
revealed
121
metabolites,
primarily
such
as
histidine
metabolism,
purine
PI3K-Akt
signaling
pathway.
integration
analyses
uncovered
five
shared
pathways,
further
combined
pathway
eight
correlate
with
19
metabolites.
current
findings
will
contribute
establishing
theoretical
framework
investigating
molecular
associated
impact
performance.
these
results
serve
foundation
capabilities
horses.
Language: Английский