Effects of 1,25-Dihydroxycholecalciferol Glycoside Supplementation on the Growth, Intestinal Health, and Immunity of Broilers from Breeders Supplemented or Not with the Same Additive

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(5), P. 434 - 434

Published: May 1, 2025

This study aimed to investigate the effects of 1,25-Dihydroxycholecalciferol glycoside (1,25(OH)2D3-G) supplementation on performance, biochemical blood, bone health, intestinal histomorphometry, and gene expressions in broilers from breeders supplemented or not with 1,25(OH)2D3-G. A total 1152 one-day-old, male Ross 308 AP chicks were distributed a completely randomized design 2 × 3 factorial arrangement. One factor was inclusion 1,25(OH)2D3-G breeders’ diets 21 62 weeks age. The other involved three levels (0, 50, 100 mg/kg) broilers’ 1 days totaled six treatments, eight replicates 24 birds per experimental unit. Breeders resulted heavier broiler at hatch, better feed conversion, higher concentrations calbindin D28K, interleukin 10, 1β Villus height absorption area jejunum showed interactions between breeder diets. this additive both sufficient increase villus It is concluded that improves growth immunity broilers.

Language: Английский

The relationship between phosphorus retention and fibroblast growth factor 23 in broiler breeders

Poultry Science, Journal Year: 2024, Volume and Issue: 103(8), P. 103889 - 103889

Published: May 23, 2024

Previous studies with broiler breeders indicate a P retention threshold when fed daily dietary levels of non-phytate (NPP) exceeding 320 mg. Fibroblast growth factor 23 (FGF23) is hormone secreted by osteocytes which modulates and could be the biological agent controls in breeders. To evaluate relationship between FGF23 threshold, 4-wk study 32-wk-old was conducted 6 treatments NPP intake 216 to 576 mg/d/h increments 80 mg/kg diet. The goals were 1) elucidate how plasma corresponds 2) determine amount for optimal egg production bone health. Results showed that 288 mg 360 intake, decreased from 33 26% but increased 130 pg/mL 220 increasing NPP. elevation range NPP/d suggests related may major regulating physiological are above

Language: Английский

Endocrine fibroblast growth factors in domestic animals

Domestic Animal Endocrinology, Journal Year: 2024, Volume and Issue: 89, P. 106872 - 106872

Published: July 9, 2024

Fibroblast growth factors (FGFs) are a group of structurally homologous yet functionally pleiotropic proteins. Canonical and intracellular FGFs have primarily autocrine or paracrine effects. However, the FGF19 subfamily, composed FGF15/19, FGF21, FGF23, act as endocrine hormones that regulate bile acid, metabolic, phosphorus homeostasis, respectively. Current research in human rodent models demonstrates potential these to target various diseases, including disorders inherited hypophosphatemia, chronic liver disease, obesity, insulin resistance. Many diseases targeted for therapeutic use humans pathophysiological overlaps domestic animals. Despite clinical economic impact, little is known about their signaling pathways major animal species compared with laboratory This review aims describe physiology FGFs, discuss current use, summarize contemporary literature regarding animals, focusing on future directions.

Language: Английский