Food & Function, Journal Year: 2024, Volume and Issue: 15(19), P. 9718 - 9733
Published: Jan. 1, 2024
Native plants are adaptable in various environmental conditions part through the production of unique phytochemicals which may have beneficial effects on human health.
Language: Английский
Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 4, 2025
Resveratrol (RES), a natural polyphenolic compound, has garnered significant attention for its therapeutic potential in various pathological conditions. This review explores how RES modulates mitophagy-the selective autophagic degradation of mitochondria essential maintaining cellular homeostasis. promotes the initiation and execution mitophagy by enhancing PINK1/Parkin-mediated mitochondrial clearance, reducing reactive oxygen species production, mitigating apoptosis, thereby preserving integrity. Additionally, regulates through activation key molecular targets such as AMP-activated protein kinase (AMPK), mechanistic target rapamycin (mTOR), deacetylases (SIRT1 SIRT3), quality control (MQC) pathways, demonstrating substantial effects multiple disease models. We provide detailed account biosynthetic pharmacokinetics, metabolic characteristics RES, focusing on role modulation implications medical applications. Potential adverse associated with clinical use are also discussed. Despite promising properties, application is limited issues bioavailability pharmacokinetic profiles. Future research should concentrate developing derivatives that precisely modulate mitophagy, unlocking new avenues therapy.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1325 - 1325
Published: Feb. 4, 2025
Dysfunctional mitochondria are present in many neurodegenerative diseases, such as spinocerebellar ataxia type 3 (SCA3), also known Machado–Joseph disease (MJD). SCA3/MJD, the most frequent worldwide, is caused by abnormal expansion of polyglutamine tract (polyQ) at ataxin-3. This protein to deubiquitinate key proteins Parkin, which required for mitophagy. Ataxin-3 interacts with Beclin1 (essential initiating autophagosome formation adjacent mitochondria), well mitochondrial cristae TBK1. To identify other mitophagy pathway (according KEGG database) that can interact ataxin-3, here we developed a pipeline silico analyses protein–protein interactions (PPIs), called auto-p2docking. Containerized Docker, auto-p2docking ensures reproducibility and reduces number errors through its simplified configuration. Its architecture consists 22 modules, used develop 12 protocols but be specified according user needs. In this work, 45 putative ataxin-3 interactors (53% novel), using interacting regions validation. Furthermore, predict from both Parkin-independent -dependent mechanisms affected polyQ expansion.
Language: Английский
Citations
0
European Journal of Cell Biology, Journal Year: 2025, Volume and Issue: unknown, P. 151488 - 151488
Published: April 1, 2025
Mitochondria adapt to the cell proliferative demands induced by growth factors through dynamic changes in morphology, distribution, and metabolic activity. Galectin-8 (Gal-8), a carbohydrate-binding protein that promotes proliferation transactivating EGFR-ERK signaling pathway, is overexpressed several cancers. However, its impact on mitochondrial dynamics during remains unknown. Using MDCK RPTEC kidney epithelial cells, we demonstrate Gal-8 induces fragmentation perinuclear redistribution. Additionally, mitochondria adopt donut-shaped morphologies, live-cell imaging with two Keima-based reporters demonstrates Gal-8-induced mitophagy. ERK inhibition abrogates all these proliferation. Studies established mutant versions of CHO cells reveal response require interactions between N-terminal carbohydrate recognition domain α-2,3-sialylated N-glycans at surface. DRP1, key regulator fission, becomes phosphorylated or an ERK-dependent manner, mediating Bafilomycin A proliferation, suggesting mitophagy serves as adaptation demands. Functional analysis under stimulation shows maintain active electron transport chain, partially uncoupled from ATP synthesis, increased membrane potential, indicative healthy mitochondria. Meanwhile, exhibit extracellular acidification rate lactate production via aerobic glycolysis, hallmark state. Our findings integrate adaptations potential implications for physiology, disease, therapeutic strategies.
Language: Английский
Citations
0
Metabolites, Journal Year: 2025, Volume and Issue: 15(5), P. 287 - 287
Published: April 24, 2025
Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty (NAFLD), is rapidly becoming the most prevalent form of chronic in both pediatric and adult populations. It encompasses a wide spectrum abnormalities, ranging from simple fat accumulation to severe conditions such inflammation, fibrosis, cirrhosis, cancer. Major risk factors for MASLD include obesity, insulin resistance, type 2 diabetes, hypertriglyceridemia. Methods: This narrative review employed comprehensive search recent literature identify latest studies on relationship between MAFLD health consequences treatment options prevent long-term damage other organs. Additionally, article presents perspectives diagnostic biomarkers. Results: Childhood obesity linked multitude comorbid remains primary factor obesity. abnormal have detrimental effects into adulthood. Scientific evidence unequivocally demonstrates role obesity-related conditions, dyslipidemia, hyperglycemia, development progression MASLD. Oxidative stress, stemming mitochondrial dysfunction, leading discusses interconnections oxidative Conclusions: Atherogenic endothelial cytokines collectively contribute Potential targets are focused prevention use drugs address elevated blood lipid levels.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 14, 2024
Introduction Diabetic ketoacidosis (DKA) is a severe and potentially fatal acute complication in diabetic patients, commonly occurring type 1 diabetes (T1D) but also seen 2 (T2D). The pathogenesis of DKA involves complex physiological processes that are not fully understood, especially the role mitochondria. Mitochondria, known as powerhouse cells, plays crucial oxidative phosphorylation ATP production, which vital various metabolic diseases, including diabetes. However, exact causal relationship between mitochondrial dysfunction remains unclear. Methods This study employed Mendelian randomization (MR) analysis protein-protein interaction (PPI) networks to systematically explore relationships DNA copy number (mtDNA-CN) specific proteins with DKA. We used bidirectional MR genome-wide association (GWAS) data from openGWAS database investigate effects mtDNA-CN 64 mitochondrial-related on its subtypes (T1DKA, T2DKA, unspecified-DKA). Results revealed increased significantly reduces risk DKA, whereas effect was significant. Mitochondrial-related such MRPL32, MRPL33, COX5B, DNAJC19, NDUFB8 showed negative indicating their potential protective roles. Conversely, ATP5F1B COX4I2 have positive excessive production patients may be detrimental health increase complications Discussion results emphasize necessity protecting function order reduce offers novel perspectives molecular pathways involved emphasizing critical functions mt-DNA distinct proteins. These evidences only enhance our comprehension implications diabetes-related identify therapeutic targets for individualized treatment approaches, thereby making substantial contribution clinical care public initiatives.
Language: Английский
Citations
3
Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0
Published: Jan. 1, 2024
Aging is a major risk factor for cardiovascular diseases (CVD), and mitochondrial autophagy impairment considered significant physiological change associated with aging. Endothelial cells play crucial role in maintaining vascular homeostasis function, participating various processes such as regulating tone, coagulation, angiogenesis, inflammatory responses. As aging progresses, endothelial worsens, leading to the development of numerous diseases. Therefore, vital preventing treating age-related However, there currently lack systematic reviews this area. To address gap, we have written review provide new research therapeutic strategies managing
Language: Английский
Citations
2
Journal of Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 74(4)
Published: Nov. 8, 2024
Language: Английский
Citations
2
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: June 19, 2024
Lung cancer, recognized globally as a leading cause of malignancy-associated morbidity and mortality, is marked by its high prevalence lethality, garnering extensive attention within the medical community. Mitophagy critical cellular process that plays crucial role in regulating metabolism ensuring quality control cells. Its relevance to lung cancer has garnered significant among researchers scientists. Mitophagy’s involvement encompasses initiation, progression, metastatic dissemination treatment. The regulatory landscape mitophagy complex, involving numerous signaling proteins pathways may exhibit aberrant alterations or mutations tumor environment. In field treatment, regulation considered key determining chemotherapy, radiation therapy, other treatment options, drug resistance. Contemporary investigations are directed towards harnessing modulators, both inhibitors activators, therapeutic strategies, with an emphasis on achieving specificity minimize collateral damage healthy populations. Furthermore, molecular constituents affiliated mitophagy, serving potential biomarkers, offer promising avenues for enhancing diagnostic accuracy, prognostic assessment, prediction responses cancer. Future endeavors will also involve investigating impact composition function immune cells microenvironment, aiming enhance our understanding how modulates response This review aims comprehensively overview recent advancements about genesis, progenesis metastasis, We discussed future research direction
Language: Английский
Citations
1
Food & Function, Journal Year: 2024, Volume and Issue: 15(19), P. 9718 - 9733
Published: Jan. 1, 2024
Native plants are adaptable in various environmental conditions part through the production of unique phytochemicals which may have beneficial effects on human health.
Language: Английский
Citations
0