Modeling Musculoskeletal Disorders in Zebrafish: Advancements in Muscle and Bone Research DOI Creative Commons
Luca Dalle Carbonare, Michele Braggio, Arianna Minoia

et al.

Cells, Journal Year: 2024, Volume and Issue: 14(1), P. 28 - 28

Published: Dec. 30, 2024

Zebrafish (Danio rerio) have emerged as a valuable model organism for investigating musculoskeletal development and the pathophysiology of associated diseases. Key genes biological processes in zebrafish that closely mirror those humans, rapid development, transparent embryos make ideal vivo studies bone muscle formation, well molecular mechanisms underlying disorders. This review focuses on utility modeling various conditions, with an emphasis diseases such osteoporosis osteogenesis imperfecta, disorders like Duchenne muscular dystrophy. These models provided significant insights into pathways involved these diseases, helping to identify key genetic biochemical factors contribute their progression. findings also advanced our understanding disease facilitated potential therapeutic strategies

Language: Английский

Aging: a Struggle for Beneficial to Overcome Negative Factors made by Muscle and Bone DOI
Steven S. Welc,

Marco Brotto,

Kenneth E. White

et al.

Mechanisms of Ageing and Development, Journal Year: 2025, Volume and Issue: unknown, P. 112039 - 112039

Published: Feb. 1, 2025

Language: Английский

Citations

0
Keratocan Improves Muscle Wasting in Sarcopenia by Promoting Skeletal Muscle Development and Fast‐Twitch Fibre Synthesis DOI Creative Commons
Xu Chen, Yanyan Zhang,

Zhibo Deng

et al.

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nutrition and Physical Activity in Musculoskeletal Health DOI Creative Commons
Ligia J. Domínguez, Nicola Veronese, Lee Smith

et al.

Endocrines, Journal Year: 2025, Volume and Issue: 6(1), P. 10 - 10

Published: March 4, 2025

A balanced diet and regular physical activity are essential for maintaining musculoskeletal health. Key nutrients such as calcium, vitamin D, protein especially important preventing falls fractures. While the benefits of these well-established, other dietary components have not been studied extensively. For instance, vegetables, which rich in vital muscle bone health, play a crucial role Over recent decades, great emphasis has given to combinations foods patterns that may synergistic or antagonistic effects. Despite challenges researching impact nutrition on health due extensive heterogeneity results, healthcare professionals should continue promote healthy eating activity, principles be emphasized public initiatives. Ultimately, sufficient diet, abundant plant-based low processed discretionary foods, along with consistent remains most effective strategy prevention issues. This article aims review updated literature years links between skeletal

Language: Английский

Citations

0
The bone microenvironment: new insights into the role of stem cells and cell communication in bone regeneration DOI Creative Commons
Luca Dalle Carbonare, Mattia Cominacini, Elisabetta Trabetti

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 12, 2025

Mesenchymal stem cells (MSCs) play a crucial role in bone formation and remodeling. Intrinsic genetic factors extrinsic environmental cues regulate their differentiation into osteoblasts. Within the microenvironment, complex network of biochemical biomechanical signals orchestrates homeostasis regeneration. In addition, crosstalk among MSCs, immune cells, neighboring cells-mediated by extracellular vesicles non-coding RNAs (such as circular micro RNAs) -profoundly influences osteogenic Recent studies have explored specific signaling pathways that contribute to effective regeneration, highlighting potential manipulating microenvironment enhance MSC functionality. The integration advanced biomaterials, gene editing techniques, controlled delivery systems is paving way for more targeted efficient regenerative therapies. Furthermore, artificial intelligence could improve tissue engineering, optimize biomaterial design, enable personalized treatment strategies. This review explores latest advancements emphasizing intricate interplay molecules. By providing comprehensive overview these mechanisms clinical implications, we aim shed light on future research directions this rapidly evolving field.

Language: Английский

Citations

0
Electrical stimulation paradigms on muscle quality and bone mineral density after spinal cord injury DOI Creative Commons
Ashraf S. Gorgey,

Siddharth Venigalla,

Jakob N. Deitrich

et al.

Osteoporosis International, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

Citations

0
Exercise for improving bone health in patients with AIRDs: Understanding underlying biology and physiology DOI Creative Commons
İlke Coşkun Benlidayı, Latika Gupta, Jasmine Parihar

et al.

International Journal of Rheumatic Diseases, Journal Year: 2024, Volume and Issue: 27(11)

Published: Oct. 28, 2024

Abstract Exercise has numerous health benefits in patients with autoimmune inflammatory rheumatic diseases (AIRDs). Regular physical activity can help maintain/improve bone health. The aim of the present article was to review current knowledge on effects exercise AIRDs, particularly those experiencing a high corticosteroid burden. also aimed discuss potential mechanisms underlying activity/exercise tissue. Potential explanations regarding role AIRDs include anti‐inflammatory effects, mechanical loading, improvement muscle strength, hormonal changes, balance, and telomere erosion, deoxyribonucleic acid methylation, gene expression. Current evidence outcomes is predominantly derived from studies focused rheumatoid arthritis. Expanding research other conditions would enhance overall understanding this topic.

Language: Английский

Citations

2
Comparative Analysis of Myokines and Bone Metabolism Markers in Prepubertal Vegetarian and Omnivorous Children DOI Open Access
Jadwiga Ambroszkiewicz, Joanna Gajewska, Katarzyna Szamotulska

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(13), P. 2009 - 2009

Published: June 25, 2024

The role of bone and muscle as endocrine organs may be important contributing factors for children’s growth development. Myokines, secreted by cells, play a in regulating metabolism, either directly or indirectly. Conversely, markers reflecting the balance between formation resorption, can also influence myokine secretion. This study investigated panel serum myokines their relationships with metabolism children following vegetarian omnivorous diets. A cohort sixty-eight healthy prepubertal children, comprising 44 vegetarians 24 omnivores, participated this study. Anthropometric measurements, dietary assessments, biochemical analyses were conducted. To evaluate concentrations myokines, an enzyme-linked immunosorbent assay (ELISA) was used. studied did not differ regarding levels, except higher concentration decorin group (p = 0.020). demonstrated distinct pattern compared to lower levels N-terminal propeptide type I procollagen (P1NP) 0.001) elevated C-terminal telopeptide collagen (CTX-I) 0.018). Consequently, P1NP/CTX-I ratio significantly decreased vegetarians. diet showed impaired reduced increased resorption. Higher decorin, involved fibrillogenesis essential tissue structure function, suggest potential compensatory mechanism maintaining homeostasis observed significant positive correlations myostatin markers, including P1NP soluble receptor activator nuclear factor kappa-B ligand (sRANKL), interplay potentially through RANK/RANKL/OPG signaling pathway.

Language: Английский

Citations

1
Sonographic Features of Rectus Femoris Muscle in Patients with Metabolic Dysfunction-Associated Fatty Liver Disease and Their Correlation with Body Composition Parameters and Muscle Strength: Results of a Single-Center Cross-Sectional Study DOI Creative Commons
А.Ф. Шептулина, A. A. Yafarova,

Elvira M. Mamutova

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1684 - 1684

Published: July 28, 2024

This study aimed to describe sonographic features of rectus femoris muscle (RFM) in patients with metabolic dysfunction-associated fatty liver disease (MASLD) and their correlation body composition parameters strength. A total 67 MASLD underwent dual-energy X-ray absorptiometry (DEXA), bioimpedance analysis (BIA), strength measurement (grip [GS] chair stand test [CST]), ultrasound (US) investigation the RFM dominant thigh using a 4 18 MHz linear probe. exhibited increased echogenicity, possibly due infiltration. We confirmed that greater subcutaneous fat thickness, smaller was mass (p < 0.001), lower 0.001 for GS p = 0.002 CST). On contrary, anteroposterior diameter (APD) RFM, higher 0.007 In addition, APD stiffness direct bone mineral density values lumbar spine 0.005 both concluded US can be helpful identifying at high risk musculoskeletal disorders given repeated point-of-care clinical evaluations.

Language: Английский

Citations

0
Modeling Musculoskeletal Disorders in Zebrafish: Advancements in Muscle and Bone Research DOI Creative Commons
Luca Dalle Carbonare, Michele Braggio, Arianna Minoia

et al.

Cells, Journal Year: 2024, Volume and Issue: 14(1), P. 28 - 28

Published: Dec. 30, 2024

Zebrafish (Danio rerio) have emerged as a valuable model organism for investigating musculoskeletal development and the pathophysiology of associated diseases. Key genes biological processes in zebrafish that closely mirror those humans, rapid development, transparent embryos make ideal vivo studies bone muscle formation, well molecular mechanisms underlying disorders. This review focuses on utility modeling various conditions, with an emphasis diseases such osteoporosis osteogenesis imperfecta, disorders like Duchenne muscular dystrophy. These models provided significant insights into pathways involved these diseases, helping to identify key genetic biochemical factors contribute their progression. findings also advanced our understanding disease facilitated potential therapeutic strategies

Language: Английский

Citations

0