B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses DOI Creative Commons

Marta Sampietro,

Marco Cellani,

Cristina Scielzo

et al.

FEBS Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Cells sense physical cues from their environment and convert them into biochemical responses through mechanotransduction. Unlike solid tumours, the role of such forces in haematological cancers is underexplored. In this context, immune cells experience dynamic mechanical stimuli as they migrate, extravasate home to specific tissues. Understanding how these shape B‐cell function malignancy represents a groundbreaking area research. This review examines key mechanosensory pathways molecules involved lymphocyte mechanotransduction, beginning with proteins at plasma membrane, followed by intracellular signal propagation cytoskeleton, eventually highlighting nucleus ‘signal actuator’. Subsequently, we cover some measurement approaches advanced systems investigate tumour biomechanics, application context B cells. Finally, focus on implications mechanobiology leukaemia, identifying malignancies that could serve potential ‘mechano‐targets’ for personalised therapies. emphasises need understand lymphocytes generate, respond stimuli, which open avenues future biomedical innovations. Impact statement Our particularly valuable underexplored cell malignancies, while also discussing emerging techniques can advance research area. It bridges immunology, cancer biology way will be interest researchers across three main fields.

Language: Английский

The mechanopathology of the tumor microenvironment: detection techniques, molecular mechanisms and therapeutic opportunities DOI Creative Commons

Simón I. Angeli,

Constantina Neophytou,

Maria Kalli

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 18, 2025

The mechanical properties of the tumor microenvironment (TME) undergo significant changes during growth, primarily driven by alterations in extracellular (ECM) stiffness and viscoelasticity. These not only promote progression but also hinder therapeutic efficacy impairing drug delivery activating mechanotransduction pathways that regulate crucial cellular processes such as migration, proliferation, resistance to therapy. In this review, we examine mechanisms through which cells sense transmit signals maintain homeostasis biomechanically altered TME. We explore current computational modelling strategies for pathways, highlighting need developing models incorporate additional components mechanosignaling machinery. Furthermore, review available methods measuring tumors clinical settings aiming at restoring TME blocking deregulated pathways. Finally, propose proper characterization a deeper understanding landscape TME, both tissue levels, are essential account influence forces on treatment efficacy.

Language: Английский

Citations

1
Mechanotransduction in Development: A Focus on Angiogenesis DOI Creative Commons
Simona Alibrandi, Carmela Rinaldi, Sergio Lucio Vinci

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 346 - 346

Published: March 27, 2025

Cells respond to external mechanical cues and transduce these forces into biological signals. This process is known as mechanotransduction requires a group of proteins called mechanosensors. peculiar class receptors include extracellular matrix proteins, plasma membrane the cytoskeleton nuclear envelope. These cell components are responsive wide spectrum physical including stiffness, tensile force, hydrostatic pressure shear stress. Among mechanotransducers, Transient Receptor Potential (TRP) PIEZO family members mechanosensitive ion channels, coupling force transduction with intracellular cation transport. Their activity contributes embryo development, tissue remodeling repair, homeostasis. In particular, vessel development driven by hemodynamic such flow direction Perturbed involved in several pathological vascular phenotypes hereditary hemorrhagic telangiectasia. review conceived summarize most recent findings development. We first collected main features proteins. However, we focused on role during Mechanosensitive channels their function also discussed, focus brain morphogenesis.

Language: Английский

Citations

0
B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses DOI Creative Commons

Marta Sampietro,

Marco Cellani,

Cristina Scielzo

et al.

FEBS Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Cells sense physical cues from their environment and convert them into biochemical responses through mechanotransduction. Unlike solid tumours, the role of such forces in haematological cancers is underexplored. In this context, immune cells experience dynamic mechanical stimuli as they migrate, extravasate home to specific tissues. Understanding how these shape B‐cell function malignancy represents a groundbreaking area research. This review examines key mechanosensory pathways molecules involved lymphocyte mechanotransduction, beginning with proteins at plasma membrane, followed by intracellular signal propagation cytoskeleton, eventually highlighting nucleus ‘signal actuator’. Subsequently, we cover some measurement approaches advanced systems investigate tumour biomechanics, application context B cells. Finally, focus on implications mechanobiology leukaemia, identifying malignancies that could serve potential ‘mechano‐targets’ for personalised therapies. emphasises need understand lymphocytes generate, respond stimuli, which open avenues future biomedical innovations. Impact statement Our particularly valuable underexplored cell malignancies, while also discussing emerging techniques can advance research area. It bridges immunology, cancer biology way will be interest researchers across three main fields.

Language: Английский

Citations

0