
Clinical Neurophysiology Practice, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Clinical Neurophysiology Practice, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(11-12), P. 2025 - 2046
Published: Oct. 7, 2024
Mitochondria dysfunction is implicated in cell death, inflammation, and autoimmunity. During viral infections, some viruses employ different strategies to disrupt mitochondria-dependent apoptosis, while others, including SARS-CoV-2, induce host apoptosis facilitate replication immune system modulation. Given mitochondrial DNAs (mtDNA) role as a pro-inflammatory damage-associated molecular pattern inflammatory diseases, we examined its levels the serum of COVID-19 patients found it be high relative healthy donors. Furthermore, comparison protein profiles between individuals SARS-CoV-2-infected revealed unique bands patients. Using mass spectroscopy, identified over 15 proteins, whose were 4- 780-fold higher. As mtDNA release from mitochondria mediated by oligomeric form mitochondrial-gatekeeper-the voltage-dependent anion-selective channel 1 (VDAC1)-we investigated whether SARS-CoV-2 alters VDAC1 expression. Among three selected small envelope (E), nucleocapsid (N), accessory 3b E-protein induced overexpression, oligomerization, release. Additionally, this led dysfunction, evidenced increased ROS production cytosolic Ca
Language: Английский
Citations
4Published: March 18, 2025
Language: Английский
Citations
0Journal of Antimicrobial Chemotherapy, Journal Year: 2025, Volume and Issue: unknown
Published: May 16, 2025
Abstract Antibiotics are diverse in their utility clinical care. They widely prescribed for antimicrobial effect and used as modulators, although rarely, of non-infectious conditions, to influence immune responses, decrease morbidity improve quality life. This review provides a concise summary different classes antibiotics unique properties that allow them be the treatment conditions.
Language: Английский
Citations
0Clinical Neurophysiology Practice, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0